Research

Items by Mrsny, Randall

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Number of items: 61.

Book/s

Mrsny, R. J. and Daugherty, A. L., eds., 2009. Proteins and Peptides: Pharmacokinetic, Pharmacodynamic, and Metabolic Outcomes. New York: Informa Healthcare.

Yui, N., Mrsny, R. and Park, K., eds., 2004. Multi-Reflexive Polymers and Hydrogels: Understanding and Designing Fast-Responsive Polymeric Systems. Boca Raton, Florida: CRC Press.

Park, K. and Mrsny, R. J., eds., 2000. Controlled Drug Delivery: Designing Technologies for the Future. Washington, DC: ACS Books.

Book Sections

Santos Cravo, A. and Mrsny, R. J., 2013. A time travel journey through cancer therapies. In: Bae, Y. H., Mrsny, R. J. and Park, K., eds. Cancer targeted drug delivery. New York: Springer, pp. 3-35.

Sharma, V. K., Chih, H. W., Mrsny, R. J. and Daugherty, A. L., 2009. The formulation and delivery of monoclonal antibodies. In: An, Z., ed. Therapeutic Monoclonal Antibodies: From Bench to Clinic. Hoboken, NJ: Wiley, pp. 671-705.

Mrsny, R. J., 2009. Metabolic processes at injection sites affecting pharmacokinetics, pharmacodynamics and metabolism of protein and peptide therapeutics. In: Mrsny, R. J. and Daugherty, A. L., eds. Proteins and Peptides: Pharmacokinetic, Pharmacodynamic, and Metabolic Outcomes. New York: Informa Healthcare, pp. 80-105.

Mrsny, R. J., 2006. Active targeting strategies in cancer with a focus on potential nanotechnology applications. In: Amiji, M. M., ed. Nanotechnology in Cancer Therapeutics. Boca Raton, Florida: CRC Press, pp. 19-42.

McCormick, B. A. and Mrsny, R. J., 2006. NF-kB-independent responses activated by bacterial-epithelial interactions: the role ofarachidonic acid metabolites. In: McCormick, B. A., ed. Bacterial-Epithelial Cell Cross-Talk: Molecular Mechanisms in Pathognesis. Cambridge, MA: Cambridge Publishing, pp. 269-300.

Park, K., Yui, N. and Mrsny, R. J., 2004. A perspective on current and future synthetic reflexive systems. In: Yui, N., Mrsny, R. and Park, K., eds. Multi-Reflexive Polymers and Hydrogels: Understanding and Designing Fast-Responsive Polymeric Systems. Boca Raton, Florida: CRC Press, pp. 427-437.

Mrsny, R. J., 2004. Learning from nature: examples of rapid, repetitive, responsive biological events. In: Yui, N., Mrsny, R. J. and Park, K., eds. Multi-Reflexive Polymers and Hydrogels: Understanding and Designing Fast-Responsive Polymeric Systems. Boca Raton, Florida: CRC Press, pp. 3-15.

Mrsny, R. J., 2004. Tissue and cell specific targeting. In: Amiji, M. M., ed. Gene Delivery: Principles and Applications. Boca Raton, Florida: CRC Press, pp. 5-27.

Keller, G. A., Li, W. and Mrsny, R. J., 2000. Targeting macromolecular therapeutics to specific cell organelles. In: Park, K. and Mrsny, R. J., eds. Controlled Drug Delivery: Designing Technologies for the Future. Vol. 752. Washington, DC: ACS Books, pp. 168-183. (ACS Symposium Series)

Articles

Liu, Z., Meng, F., Li, C., Zhou, X., Zeng, X., He, Y., Mrsny, R.J., Liu, M., Hu, X., Hu, J.-F. and Li, T., 2014. Human umbilical cord mesenchymal stromal cells rescue mice from acetaminophen-induced acute liver failure. Cytotherapy, 16 (9), pp. 1207-1219.

Agbor, T. A., Demma, Z., Mrsny, R. J., Castillo, A., Boll, E. J. and Mccormick, B. A., 2014. The oxido-reductase enzyme glutathione peroxidase 4 (GPX4) governs Salmonella Typhimurium-induced neutrophil transepithelial migration. Cellular Microbiology, 16 (9), pp. 1339-1353.

Kinnunen, H. M. and Mrsny, R. J., 2014. Improving the outcomes of biopharmaceutical delivery via the subcutaneous route by understanding the chemical, physical and physiological properties of the subcutaneous injection site. Journal of Controlled Release, 182 (1), pp. 22-32.

Carter, E., Lau, C. Y., Tosh, D., Ward, S. G. and Mrsny, R. J., 2013. Cell penetrating peptides fail to induce an innate immune response in epithelial cells in vitro : Implications for continued therapeutic use. European Journal of Pharmaceutics and Biopharmaceutics, 85 (1), pp. 12-19.

Zhang, H., Jiao, W., Sun, L., Fan, J., Chen, M., Wang, H., Xu, X., Shen, A., Li, T., Niu, B., Ge, S., Li, W., Cui, J., Wang, G., Sun, J., Fan, X., Hu, X., Mrsny, R., Hoffman, A. R. and Hu, J.-F., 2013. Intrachromosomal looping is required for activation of endogenous pluripotency genes during reprogramming. Cell Stem Cell, 13 (1), pp. 30-35.

Liu, K., Hearne, K., Mrsny, A., Staka, C. and Mrsny, R. J., 2012. A strategy to improve selectivity and targeting to epithelial-derived cancer cells. Journal of Controlled Release, 164 (2), pp. 205-212.

Mrsny, R. J., 2012. Oral drug delivery research in Europe. Journal of Controlled Release, 161 (2), pp. 247-253.

Daugherty, A. L., Rangell, L. K., Eckert, R., Zavala-Solorio, J., Peale, F. and Mrsny, R. J., 2011. Sustained release formulations of rhVEGF165 produce a durable response in a murine model of peripheral angiogenesis. European Journal of Pharmaceutics and Biopharmaceutics, 78 (2), pp. 289-297.

Brayden, D. J. and Mrsny, R. J., 2011. Oral peptide delivery: Prioritizing the leading technologies. Therapeutic Delivery, 2 (12), pp. 1567-1573.

Lipp, R., Mrsny, R. and Park, K., 2010. Seventh international nanomedicine and drug delivery symposium (NanoDDS'09). Journal of Controlled Release, 146 (2), p. 163.

Daugherty, A. L. and Mrsny, R. J., 2010. Local tissue distribution and cellular fate of vascular endothelial growth factor (VEGF) following intramuscular injection. Journal of Drug Targeting, 18 (1), pp. 27-35.

Mrsny, R. J., 2009. Lessons from nature: "Pathogen-Mimetic" systems for mucosal Nano-medicines. Advanced Drug Delivery Reviews, 61 (2), pp. 172-192.

Ward, S. G. and Mrsny, R. J., 2009. New insights into mechanisms of gastrointestinal inflammation and cancer. Current Opinion in Pharmacology, 9 (6), pp. 677-679.

Pazos, M., Siccardi, D., Mumy, K. L., Bien, J. D., Louie, S., Shi, H. N., Gronert, K., Mrsny, R. J. and McCormick, B. A., 2008. Multidrug resistance-associated transporter 2 regulates mucosal inflammation by facilitating the synthesis of hepoxilin A3. The Journal of Immunology, 181 (11), pp. 8044-8052.

Mrsny, R. J., Brown, G. T., Gerner-Smidt, K., Buret, A. G., Meddings, J. B., Quan, C., Koval, M. and Nusrat, A., 2008. A key claudin extracellular loop domain is critical for epithelial barrier integrity. American Journal Of Pathology, 172 (4), pp. 905-915.

Feighery, L. M., Cochrane, S. W., Quinn, T., Baird, A. W., O’Toole, D., Owens, S.-E., O’Donoghue, D., Mrsny, R. J. and Brayden, D. J., 2008. Myosin light chain kinase inhibition: correction of increased intestinal epithelial permeability in vitro. Pharmaceutical Research, 25 (6), pp. 1377-1386.

Wang, Z., Wade, P., Mandell, K. J., Akyildiz, A., Parkos, C. A., Mrsny, R. J. and Nusrat, A., 2007. Raf 1 represses expression of the tight junction protein occludin via activation of the zinc-finger transcription factor slug. Oncogene, 26 (8), pp. 1222-1230.

Daugherty, A. L. and Mrsny, R. J., 2006. Formulation and delivery issues for monoclonal antibody therapeutics. Advanced Drug Delivery Reviews, 58 (5-6), pp. 686-706.

Owens, S. E., Graham, W. V., Siccardi, D., Turner, J. R. and Mrsny, R. J., 2005. A strategy to identify stable membrane-permeant peptide inhibitors of myosin light chain kinase. Pharmaceutical Research, 22 (5), pp. 703-709.

Mrsny, R. J. and Nusrat, A., 2005. Adhesion proteins in cellular tight junctions: critical components in the modulation of paracellular permeability. Advanced Drug Delivery Reviews, 57 (6), pp. 809-810.

Russo, J. M., Mrsny, R. J. and et al, [N. V.], 2005. Distinct temporal-spatial roles for rho kinase and myosin light chain kinase in epithelial purse-string wound closure. Gastroenterology, 128 (4), pp. 987-1001.

Clayburgh, D. R., Barrett, T. A., Tang, Y., Meddings, J. B., Van Eldik, L. J., Watterson, D. M., Clarke, L. L., Mrsny, R. J. and Turner, J. R., 2005. Epithelial myosin light chain kinase-dependent barrier dysfunction mediates T cell activation-induce diarrhea in vivo. Journal of Clinical Investigation, 115 (10), pp. 2702-2715.

Hsieh, J. C., Tham, D. M., Feng, W., Huang, F., Embaie, S., Liu, K., Dean, D., Hertle, R., Fitzgerald, D. J. and Mrsny, R. J., 2005. Intranasal immunization strategy to impede pilin-mediated binding of Pseudomonas aeruginosa to airway epithelial cells. Infection and Immunity, 73 (11), pp. 7705-7717.

Utech, M., Ivanov, A. I., Samarin, S. N., Bruewer, M., Turner, J. R., Mrsny, R. J., Parkos, C. A. and Nusrat, A., 2005. Mechanism of IFN- g -induced endocytosis of tight junction proteins: myosin II-dependent vacuolarization of the apical plasma membrane. Molecular Biology of the Cell, 16 (10), pp. 5040-5052.

Mrsny, R. J., 2005. Modification of epithelial tight junction integrity to enhance transmucosal absorption. Critical Review of Therapeutic Drug Carrier Systems, 22 (4), pp. 331-418.

Nusrat, A., Brown, G. T., Tom, J., Drake, A., Bui, T. T., Quan, C. and Mrsny, R. J., 2005. Multiple protein interactions involving proposed extracellular loop domains of the tight junction protein occludin. Molecular Biology of the Cell, 16 (4), pp. 1725-1734.

Siccardi, D., Turner, J. R. and Mrsny, R. J., 2005. Regulation of intestinal epithelial function: a link between opportunities for macromolecular drug delivery and inflammatory bowel disease. Advanced Drug Delivery Reviews, 57 (2), pp. 219-235.

Wang, Z., Mrsny, R. J. and et al, [N. V.], 2005. The second loop of occludin is required for suppression of Raf-1induced tumor growth. Oncogene, 24 (27), pp. 4412-4420.

Nusrat, A. and Mrsny, R. J., 2005. Tight junctions; more than a permeability barrier. Advanced Drug Delivery Reviews, 57.

Mrsny, R. J., Gewirtz, A. T., Siccardi, D., Savidge, T., Hurley, B. P., Madara, J. L. and McCormick, B. A., 2004. Identification of hepoxilin A 3 in inflammatory events: a required role in neutrophil migration across intestinal epithelia. Proceedings of the National Academy of Sciences of the United States of America, 101 (19), pp. 7421-7426.

Thanou, M. and Mrsny, R. J., 2004. Modulation of tight junctional permeability (Preface). Journal of Drug Targeting, 12 (2), p. 63.

Hurley, B. P., Siccardi, D., Mrsny, R. J. and McCormick, B. A., 2004. Polymorphonuclear cell transmigration induced by Pseudomonas aeruginosa requires the eicosanoid hepoxilin A 3 1. The Journal of Immunology, 173 (9), pp. 5712-5720.

Mrsny, R. J., 2004. Strategies for targeting protein therapeutics to selected tissues and cells. Expert Opinion on Biological Therapy, 4 (1), pp. 65-73.

Thanou, M. and Mrsny, R. J., 2004. Tight junctions - more than a permeability barrier. Journal of Drug Targeting, 12 (2), p. 63.

Daugherty, A. L. and Mrsny, R. J., 2003. Emerging technologies that overcome biological barriers for therapeutic protein delivery. Expert Opinion on Biological Therapy, 3 (7), pp. 1071-1081.

Zolotarevsky, Y., Hecht, G., Koutsouris, A., Gonzalez, D. E., Quan, C., Tom, J., Mrsny, R. J. and Turner, J. R., 2002. A membrane-permeant peptide that inhibits MLC kinase restores barrier function in In Vitro models of intestinal disease. Gastroenterology, 123 (1), pp. 163-172.

Khossravi, M., Kao, Y. H., Mrsny, R. J. and Sweeney, T. D., 2002. Analysis methods of polysorbate 20: a new method to assess the stability of polysorbate 20 and established methods that may overlook degraded polysorbate 20. Pharmaceutical Research, 19 (5), pp. 634-639.

Mrsny, R. J., Daugherty, A. L., McKee, M. L. and Fitzgerald, D. J., 2002. Bacterial toxins as tools for mucosal vaccination. Drug Discovery Today, 7 (4), pp. 247-258.

Hobert, M. E., Sands, K. A., Mrsny, R. J. and Madara, J. L., 2002. Cdc42 and Rac1 regulate late events in Salmonella typhimurium -induced Interleukin-8 secretion from polarizedepithelial cells. Journal of Biological Chemistry, 277 (52), pp. 51025-51032.

Hertle, R., Mrsny, R. and Fitzgerald, D. J., 2001. Dual-function vaccine for Pseudomonas aeruginosa : characterization of chimeric exotoxin A-Pilin protein. Infection and Immunity, 69 (11), pp. 6962-6969.

Cleland, J. L., Daugherty, A. and Mrsny, R., 2001. Emerging protein delivery methods. Current Opinion in Biotechnology, 12, pp. 212-219.

Wei, Y., Mrsny, R., Blumberg, R. S., Fried, M. and Christ, A. D., 2000. Choice of microcentrifuge tubes influences T cell proliferation assay. Biotechniques, 29 (1), pp. 54-59.

Liang, T. W., Demarco, R. A., Mrsny, R. J., Gurney, A., Gray, A., Hooley, J., Aaron, H. L., Huang, A., Klassen, T., Tumas, D. B. and Fong, S., 2000. Characterization of huJAM: evidence for involvement in cell-cell contact and tight junction regulation. American Journal of Physiology - Cell Physiology, 279 (6), C1733-C1743.

Daugherty, A. L., McKee, M. L., FitzGerald, D. J. and Mrsny, R. J., 2000. Epithelial application of Pseudomonas aeruginosa exotoxin A results in a selective targeting to cells in the liver, spleen and lymph node. Journal of Controlled Release, 65 (1-2), pp. 297-302.

Hopkins, A. M., Li, D. X., Mrsny, R. J., Walsh, S. V. and Nusrat, A., 2000. Modulation of tight junction function by G protein-coupled events. Advanced Drug Delivery Reviews, 41 (3), pp. 329-340.

FitzGerald, D. and Mrsny, R. J., 2000. New approaches to antigen delivery. Critical Review of Therapeutic Drug Carrier Systems, 17 (3), pp. 165-248.

Turner, J. R., Cohen, D. E., Mrsny, R. J. and Madara, J. L., 2000. Noninvasive in vivo analysis of human small intestinal paracellular absorption: Regulation by Na+-glucose cotransport. Digestive Diseases and Sciences, 45 (11), pp. 2122-2126.

Li, D. X. and Mrsny, R. J., 2000. Oncogenic Raf-1 disrupts epithelial tight junctions via downregulation of occludin. The Journal of Cell Biology (JCB), 148 (4), pp. 791-800.

Nusrat, A., Chen, J. A., Foley, C. S., Liang, T. W., Tom, J., Cromwell, M., Quan, C. and Mrsny, R. J., 2000. The coiled-coil domain of occludin can act to organize structural and functional elements of the epithelial tight junction. Journal of Biological Chemistry, 275 (38), pp. 29816-29822.

This list was generated on Tue Oct 21 09:57:13 2014 IST.