Items by Ward, Stephen

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Number of items: 80.


Carter, E., Miron-Buchacra, G., Goldoni, S., Danahay, H., Westwick, J., Watson, M. L., Tosh, D. and Ward, S. G., 2014. Phosphoinositide 3-kinase alpha-dependent regulation of branching morphogenesis in murine embryonic lung : Evidence for a role in determining morphogenic properties of FGF7. PLoS ONE, 9 (12), e113555.

Ball, J., Archer, S. and Ward, S., 2014. PI3K inhibitors as potential therapeutics for autoimmune disease. Drug Discovery Today, 19 (8), pp. 1195-1199.


Carter, E., Lau, C. Y., Tosh, D., Ward, S. G. and Mrsny, R. J., 2013. Cell penetrating peptides fail to induce an innate immune response in epithelial cells in vitro : Implications for continued therapeutic use. European Journal of Pharmaceutics and Biopharmaceutics, 85 (1), pp. 12-19.

Foster, J. G., Carter, E., Kilty, I., Mackenzie, A. B. and Ward, S. G., 2013. Mitochondrial superoxide generation enhances P2X7R-mediated loss of cell surface CD62L on naïve human CD4+ T lymphocytes. The Journal of Immunology, 190 (4), pp. 1551-1559.


Harris, S. J., Ciuclan, L., Finan, P. M., Wymann, M. P., Walker, C., Westwick, J., Ward, S. G. and Thomas, M. J., 2012. Genetic ablation of PI3Kγ results in defective IL-17RA signalling in T lymphocytes and increased IL-17 levels. European Journal of Immunology, 42 (12), pp. 3394-3404.

Foster, J.G., Blunt, M.D., Carter, E. and Ward, S.G., 2012. Inhibition of PI3K signaling Spurs new therapeutic opportunities in inflammatory/autoimmune diseases and hematological malignancies. Pharmacological Reviews, 64 (4), pp. 1027-1054.

Blunt, M.D. and Ward, S.G., 2012. Pharmacological targeting of phosphoinositide lipid kinases and phosphatases in the immune system : Success, disappointment, and new opportunities. Frontiers in Immunology, 3, 226.

Ward, S.G. and O'Neill, L.A., 2012. Spurs in the hunt for new immunomodulatory drug targets. Current Opinion in Pharmacology, 12 (4), pp. 439-443.

Blunt, M. D. and Ward, S. G., 2012. Targeting PI3K isoforms and SHIP in the immune system: new therapeutics for inflammation and leukemia. Current Opinion in Pharmacology, 12 (4), pp. 444-451.

Pauling, J. D., Shipley, J. A., Raper, S., Watson, M. L., Ward, S. G., Harris, N. D. and McHugh, N. J., 2012. Comparison of infrared thermography and laser speckle contrast imaging for the dynamic assessment of digital microvascular function. Microvascular Research, 83 (2), pp. 162-167.

Ward, S. G., 2012. Phosphoinositide 3-kinases and leukocyte migration. Current Immunology Reviews, 8 (2), pp. 154-160.


Dowden, J., Pike, R. A., Parry, R. V., Hong, W., Muhsen, U. A. and Ward, S. G., 2011. Small molecule inhibitors that discriminate between protein arginine N-methyltransferases PRMT1 and CARM1. Organic and Biomolecular Chemistry, 9 (22), pp. 7814-7821.

Ward, S. G., Westwick, J. and Harris, S., 2011. Sat-Nav for T cells: Role of PI3K isoforms and lipid phosphatases in migration of T lymphocytes. Immunology Letters, 138 (1), pp. 15-18.

Harris, S. J., Parry, R. V., Foster, J. G., Blunt, M. D., Wang, A., Marelli-Berg, F., Westwick, J. and Ward, S. G., 2011. Evidence that the lipid phosphatase SHIP-1 regulates T lymphocyte morphology and motility. The Journal of Immunology, 186 (8), pp. 4936-4945.

Korniejewska, A., McKnight, A. J., Johnson, Z., Watson, M. L. and Ward, S. G., 2011. Expression and agonist responsiveness of CXCR3 variants in human T lymphocytes. Immunology, 132 (4), pp. 503-515.


Willox, I., Mirkina, I., Westwick, J. and Ward, S. G., 2010. Evidence for PI3K-dependent CXCR3 agonist-induced degranulation of human cord blood-derived mast cells. Molecular Immunology, 47 (14), pp. 2367-2377.

Dowden, J., Hong, W., Parry, R. V., Pike, R. A. and Ward, S. G., 2010. Toward the development of potent and selective bisubstrate inhibitors of protein arginine methyltransferases. Bioorganic & Medicinal Chemistry Letters, 20 (7), pp. 2103-2105.

Korniejewska, A., Watson, M. L. and Ward, S. G., 2010. Analysis of CXCR3 and atypical variant expression and signalling in human T lymphocytes. In: Marelli-Berg, F. M. and Nourshargh, S., eds. T-Cell Trafficking. Vol. 606. Humana Press, pp. 125-147. (Methods in Molecular Biology)

Parry, R. V., Harris, S. J. and Ward, S. G., 2010. Fine tuning T lymphocytes: A role for the lipid phosphatase SHIP-1. Biochimica et Biophysica Acta (BBA) - Proteins & Proteomics, 1804 (3), pp. 592-597.

Sun, L. R., Zhong, J. L., Cui, S. X., Li, X., Ward, S. G., Shi, Y. Q., Zhang, X. F., Cheng, Y. N., Gao, J. J. and Qu, X. J., 2010. Modulation of P-glycoprotein activity by the substituted quinoxalinone compound QA3 in adriamycin-resistant K562/A02 cells. Pharmacological Reports, 62 (2), pp. 333-342.

Parry, R. V. and Ward, S. G., 2010. Protein arginine methylation: a new handle on T lymphocytes? Trends in Immunology, 31 (4), pp. 164-169.


Colleypriest, B. J., Ward, S. G. and Tosh, D., 2009. How does inflammation cause Barrett's metaplasia? Current Opinion in Pharmacology, 9 (6), pp. 721-726.

Harris, S. J., Foster, J. G. and Ward, S. G., 2009. PI3K isoforms as drug targets in inflammatory diseases : Lessons from pharmacological and genetic strategies. Current Opinion in Investigational Drugs, 10 (11), pp. 1151-1162.

Colleypriest, B. J., Palmer, R. M., Ward, S. G. and Tosh, D., 2009. Cdx genes, inflammation and the pathogenesis of Barrett's metaplasia. Trends in Molecular Medicine, 15 (7), pp. 313-322.

Ward, S. G., 2009. Millipede-like lymphocyte crawling: feeling the way with filopodia. Immunity, 30 (3), pp. 315-317.

Wang, S. B., Cheng, Y. N., Cui, S. X., Zhong, J. L., Ward, S. G., Sun, L. R., Chen, M. H., Kokudo, N., Tang, W. and Qu, X. J., 2009. Des-gamma-carboxy prothrombin stimulates human vascular endothelial cell growth and migration. Clinical & Experimental Metastasis, 26 (5), pp. 469-477.

Ward, S. G. and Marelli-Berg, F. M., 2009. Mechanisms of chemokine and antigen-dependent T-lymphocyte navigation. Biochemical Journal, 418 (1), pp. 13-27.

Ward, S. G. and Mrsny, R. J., 2009. New insights into mechanisms of gastrointestinal inflammation and cancer. Current Opinion in Pharmacology, 9 (6), pp. 677-679.

Sun, L. R., Li, X., Cheng, Y. N., Yuan, H. Y., Chen, M. H., Tang, W., Ward, S. G. and Qu, X. J., 2009. Reversal effect of substituted 1,3-dimethyl-1H-quinoxalin-2-ones on multidrug resistance in adriamycin-resistant K562/A02 cells. Biomedicine & Pharmacotherapy, 63 (3), pp. 202-208.


Webb, A., Johnson, A., Fortunato, M., Platt, A., Crabbe, T., Christie, M. I., Watt, G. F., Ward, S. G. and Jopling, L. A., 2008. Evidence for PI-3K-dependent migration of Th17-polarized cells in response to CCR2 and CCR6 agonists. Journal of Leukocyte Biology, 84 (4), pp. 1202-1212.

Gao, F. J., Cui, S. X., Chen, M. H., Cheng, Y. N., Sun, L. R., Ward, S. G., Kokudo, N., Tang, W. and Qu, X. J., 2008. Des-gamma-carboxy prothrombin increases the expression of angiogenic factors in human hepatocellular carcinoma cells. Life Sciences, 83 (23-24), pp. 815-820.

Chen, M.-H., Cui, S.-X., Cheng, Y.-N., Sun, L.-R., Li, Q.-B., Xu, W.-F., Ward, S. G., Tang, W. and Qu, X.-J., 2008. Galloyl cyclic-imide derivative CH1104I inhibits tumor invasion through suppressing matrix metalloproteinase activity. Anti-Cancer Drugs, 19 (10), pp. 957-965.

Wang, S. B., Cheng, Y. N., Wang, F. S., Sun, L. R., Liu, C. H., Chen, G. J., Li, Y. H., Ward, S. G. and Qu, X. J., 2008. Inhibition activity of sulfated polysaccharide of Sepiella maindroni ink on matrix metalloproteinase (MMP)-2. Biomedicine & Pharmacotherapy, 62 (5), pp. 297-302.

Wright, K. L., Robertson, D. A. F., Moyer, M. P. and Ward, S. G., 2008. Long term cannabinoid receptor (CBI) blockade in obesity: Implications for the development of colorectal cancer. International Journal of Cancer, 122 (8), pp. 1920-1921.

Ward, S. G., 2008. New drug targets in inflammation: efforts to expand the anti-inflammatory armoury. British Journal of Pharmacology, 153, S5-S6.

Harris, S. J., Parry, R. V., Westwick, J. and Ward, S. G., 2008. Phosphoinositide lipid phosphatases: Natural regulators of phosphoinositide 3-kinase signaling in T lymphocytes. Journal of Biological Chemistry, 283 (5), pp. 2465-2469.


Smith, L. D., Hickman, E. S., Parry, R. V., Westwick, J. and Ward, S. G., 2007. P13Kγ is the dominant isoform involved in migratory responses of human T lymphocytes: effects of ex vivo maintenance and limitations of non-viral delivery of siRNA. Cellular Signalling, 19, pp. 2528-2539.

Smith, L. D., Hickman, E. S., Parry, R. V., Westwick, J. and Ward, S. G., 2007. PI3K gamma is the dominant isoform involved in migratory responses of human T lymphocytes: Effects of ex vivo maintenance and limitations of non-viral delivery of siRNA. Cellular Signalling, 19 (12), pp. 2528-2539.

Medina-Tato, D. A., Ward, S. G. and Watson, M. L., 2007. Phosphoinositide 3-kinase signalling in lung disease: leucocytes and beyond. Immunology, 121, pp. 448-461.

Parry, R. V., Riley, J. L. and Ward, S. G., 2007. Signalling to suit function: tailoring phosphoinositide 3-kinase during T-cell activation. Trends in Immunology, 28 (4), pp. 161-168.

Smith, L., Webb, A. and Ward, S. G., 2007. T-lymphocyte navigation and migration: beyond the PI3K paradigm. Biochemical Society Transactions, 35, pp. 193-198.

Coopman, K., Smith, L. D., Wright, K. L. and Ward, S. G., 2007. Temporal variation in CB2R levels following T lymphocyte activation: Evidence that cannabinoids modulate CXCL12-induced chemotaxis. International Immunopharmacology, 7 (3), pp. 360-371.

Crabbe, T., Welham, M. and Ward, S., 2007. The PI3K inhibitor arsenal: choose your weapon! Trends in Biochemical Sciences, 32 (10), pp. 450-456.


Medina-Tato, D. A., Ward, S. G. and Watson, M. L., 2006. Cross-regulation between class IA phosphatidyl inositol 3-kinase p110 beta and p110 delta isoforms. Inflammation Research, 55 (Suppl 2), S124-S124.

Cronshaw, D. G., Kouroumalis, A., Parry, R., Webb, A., Brown, Z. and Ward, S. G., 2006. Evidence that phospholipase C-dependent, calcium-independent mechanisms are required for directional migration of T lymphocytes in response to the CCR4 ligands CCL17 and CCL22. Journal of Leukocyte Biology, 79, pp. 1369-1380.

Medina-Tato, D. A., Watson, M. L. and Ward, S. G., 2006. Leukocyte navigation mechanisms as targets in airway diseases. Drug Discovery Today, 11 (19-20), pp. 866-879.

Parry, R. V., Whittaker, G. C., Sims, M., Edmead, C., Welham, M. J. and Ward, S. G., 2006. Ligation of CD28 stimulates the formation of a multimeric signaling complex involving Grb-2-Associated binder 2 (Gab2), Src homology phosphatase-2, and phosphatidylinositol 3-kinase: evidence that negative regulation of CD28 signaling requires the Gab2 pleckstrin homology domain. The Journal of Immunology, 176, pp. 594-602.

Irarrazabal, C. E., Burg, M. B., Ward, S. G. and Ferraris, J. D., 2006. Phosphatidylinositol 3-kinase mediates activation of ATM by high NaCl and by ionizing radiation: role in osmoprotective transcriptional regulation. Proceedings of the National Academy of Sciences of the United States of America, 103 (23), pp. 8882-8887.

Ward, S. G., 2006. T lymphocytes on the move: chemokines, PI 3-kinase and beyond. Trends in Immunology, 27 (2), pp. 80-87.


Wright, K. L., Rooney, N., Feeney, M., Tate, J., Robertson, D., Welham, M. J. and Ward, S. G., 2005. Differential expression of cannabinoid receptors in the human colon: cannabinoids promote epithelial wound healing. Gastroenterology, 129 (2), pp. 437-453.

Patel, K. M., Wright, K. L., Whittaker, P., Chakravarty, P., Watson, M. L. and Ward, S. G., 2005. Differential modulation of COX-2 expression in A549 airway epithelial cells by structurally distinct PPARγ agonists: evidence for disparate functional effects which are independent of NF-κB and PPARγ. Drug Discovery Today, 17, pp. 1098-1110.

Patel, K. M., Watson, M. L. and Ward, S. G., 2005. Differential sensitivity of class II phosphoinositide 3-kinase (PI3K) isoforms to broad spectrum P13K inhibitors. Pa2 Online, 2, 76P.

Wain, C. M., Westwick, J. and Ward, S. G., 2005. Heterologous regulation of chemokine receptor signaling by the lipid phosphate SHIP in lymphocytes. Cellular Signalling, 17, pp. 1194-1202.

Parry, R. V. and Ward, S. G., 2005. T-lymphocyte activation. Encyclopedia of Life Sciences, 2005.

Kouroumalis, A., Nibbs, R. J., Aptel, H., Wright, K. L., Kolios, G. and Ward, S. G., 2005. The chemokines CXCL9, CXCL10, and CXCL11 differentially stimulate Gα i -independent signaling and actin responses in human intestinal myofibroblasts. The Journal of Immunology, 175 (8), pp. 5403-5411.


Cronshaw, D. G., Owen, C., Brown, Z. and Ward, S. G., 2004. Activation of phosphoinositide 3-kinases by the CCR4 ligand macrophage-derived chemokine is a dispensable signal for T lymphocyte chemotaxis. The Journal of Immunology, 172 (12), pp. 7761-7770.

Wright, K. L., Weaver, S. A., Patel, K., Coopman, K., Feeney, M., Kolios, G., Robertson, D. A. F. and Ward, S. G., 2004. Differential regulation of prostaglandin E biosynthesis by interferon- g in colonic epithelial cells. British Journal of Pharmacology, 141, pp. 1091-1097.

Ward, S. G., 2004. Do phosphoinositide 3-kinases direct lymphocyte navigation? Trends in Immunology, 25 (2), pp. 67-74.

Kolios, G., Valatas, V. and Ward, S. G., 2004. Nitric oxide in inflammatory bowel disease: a universal messenger in an unsolved puzzle. Immunology, 113, pp. 427-437.


Curnock, A. P. and Ward, S. G., 2003. Development and characterisation of tetracycline-regulated phosphoinositide 3-kinase mutrants: assessing the role of multiple phosphoinositide 3-kinases in chemokine signalling. Journal of Immunological Methods, 273, pp. 29-41.

Patel, K. M., Whittaker, P., Watson, M. L. and Ward, S. G., 2003. Disparate effects of PPAR g ligands on PI3K and MAPK signalling pathways. Inflammation Research, Supplement 2, S174.

Ward, S. G. and Finan, P., 2003. Isoform-specific phosphoinositide 3-kinase inhibitors as therapeutic agents. Current Opinion in Pharmacology, 3, pp. 426-434.

Curnock, A. P., Sotsios, Y., Wright, K. L. and Ward, S. G., 2003. Optimal chemotactic responses of leukemic T cells to stromal cell-derived factor-1 requires the activation of both class 1A and 1B phosphoinositide 3-kinases. The Journal of Immunology, 170 (8), pp. 4021-4030.

Ward, S. G., Finan, P. and Welham, M. J., 2003. P13K comes of age. Nature Immunology, 4 (1), p. 2.

Ward, S. G. and O'Neill, L. A. J., 2003. Spotlight on new anti-inflammatory drug targets in the immune system. Current Opinion in Immunology, 3, pp. 391-395.

Ward, S. G., Sotsios, Y., Dowden, J., Bruce, I. and Finan, P., 2003. Therapeutic potential of phosphoinositide 3-kinase inhibitors. Chemistry & Biology, 10, pp. 207-213.

O'Neill, L. A. J., Brown, Z. and Ward, S. G., 2003. Toll-like receptors in the spotlight. Nature Immunology, 4, p. 299.


Curnock, A. P., Logan, M. K. and Ward, S. G., 2002. Chemokine signalling: pivoting around multiple phosphinositide 3-kinases. Arthritis & Rheumatism, 105, pp. 125-136.

Freeburn, R. W., Wright, K. L., Burgess, S. J., Astoul, E., Cantrell, D. A. and Ward, S. G., 2002. Evidence that SHIP-1 contributes to phosphatidylinositol 3,4,5-trisphosphate metabolism in T lymphocytes and can regulate novel phosphoinositide 3-kinase effectors. The Journal of Immunology, 169 (10), pp. 5441-5450.

Williams, S., Ward, S. G. and Watson, M. L., 2002. The regulation of cyclooxygenase in tracheal epithelial cell lines. Pediatric Pulmonology, 231, S22.


Dowden, J. and Ward, S. G., 2001. Inhibitors of p56 lck : assessing their potential as tools for manipulating T-lymphocyte activation. Expert Opinion on Therapeutic Patents, 11 (2), pp. 295-306.

Astoul, E., Edmunds, C., Cantrell, D. A. and Ward, S. G., 2001. PI 3-K and T-cell activation: limitations of T-leukemic cell lines as signaling models. Trends in Immunology, 22 (9), pp. 490-496.

Lavelle, M. J., Smith, A. W., Ward, S. G. and Watson, M. L., 2001. Phosphoinositide 3-kinase and PTEN activity in airway epithelial cells. Pediatric Pulmonology, S22, pp. 196-197.

Ward, S. G. and Cantrell, D. A., 2001. Phosphoinositide 3-kinases in T lymphocyte activation. Current Opinion in Immunology, 13, pp. 332-338.

Weaver, S. A. and Ward, S. G., 2001. Phosphoinositide 3-kinases in the gut: a link between inflammation and cancer? Molecular Medicine Today, 7, pp. 455-462.

Weaver, S. A., Russo, M. P., Wright, K. L., Kolios, G., Jobin, C., Robertson, D. A. F. and Ward, S. G., 2001. Regulatory role of phosphatidylinositol 3-kinase on TNF-α-induced cyclooxygenase 2 expression in colonic epithelial cells. Gastroenterology, 120 (5), pp. 1117-1127.


Sotsios, Y., Blair, P. J., Westwick, J. and Ward, S. G., 2000. Disparate effects of phorbol esters, CD3 and the costimulatory receptors CD2 and CD28 on RANTES secretion by human T lymphocytes. Immunology, 101 (1), pp. 30-37.

Sotsios, Y. and Ward, S. G., 2000. Phosphoinositide 3-kinase: a key biochemical signal for cell migration in response to chemokines. Immunological Reviews, 177, pp. 217-235.


Ward, S. G., Mills, S. J., Liu, C., Westwick, J. and Potter, B. V. L., 1995. D-myo-inositol 1,4,5-trisphosphate analogues modified at the 3-position inhibit phosphatidylinositol 3-kinase. Journal of Biological Chemistry, 270 (20), pp. 12075-12084.


Ward, S. G., Lampe, D., Liu, C., Potter, B. V. L. and Westwick, J., 1994. Calcium release activity and metabolism of inositol 1,4,5-trisphosphate in T cells : modulation by novel inositol 1,4,5-trisphosphate 5-phosphatase inhibitors. European Journal of Biochemistry, 222 (2), pp. 515-523.

This list was generated on Sat Apr 25 11:57:22 2015 IST.