Items by Nathubhai, Amit
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Number of items: 22.
Book Sections
Dixon, M. J., Nathubhai, A., Andersen, O. A., van Aalten, D. M. F. and Eggleston, I. M., 2009. Synthesis and Structure-based Dissection of Cyclic Peptide Chitinase Inhibitors: New Leads for Antifungal and Anti-inflammatory Drugs. In: DelValle, S., Escher, E. and Lubell, W. D., eds. Peptides for Youth - The Proceedings of the 20th American Peptide Symposium. Springer, pp. 525-526. (Advances in Experimental Medicine and Biology)
Articles
Jevglevskis, M., Lee, G. L., Nathubhai, A., Petrova, Y., James, T., Threadgill, M., Woodman, T. and Lloyd, M., 2017. A novel colorimetric assay for α-methylacyl-CoA racemase 1A (AMACR; P504S) utilizing the elimination of 2,4-dinitrophenolate. Chemical Communications, 53 (37), pp. 5087-5090.
Nathubhai, A., Haikarainen, T., Koivunen, J., Murthy, S., Koumanov, F., Lloyd, M., Holman, G., Pihlajaniemi, T., Tosh, D., Lehtio, L. and Threadgill, M., 2017. Highly potent and isoform-selective dual-site-binding tankyrase/Wnt signaling inhibitors that increase cellular glucose uptake and have anti-proliferative activity. Journal of Medicinal Chemistry, 60 (2), pp. 814-820.
Nathubhai, A., Haikarainen, T., Hayward, P. C., Munoz-Descalzo, S., Thompson, A. S., Lloyd, M. D., Lehtio, L. and Threadgill, M., 2016. Structure-activity relationships of 2-arylquinazolin-4-ones as highly selective and potent inhibitors of the tankyrases. European Journal of Medicinal Chemistry, 118, pp. 316-327.
Paine, H. A., Nathubhai, A., Woon, E. C. Y., Sunderland, P. T., Wood, P. J., Mahon, M. F., Lloyd, M. D., Thompson, A. S., Haikarainen, T., Narwal, M., Lehtio, L. and Threadgill, M. D., 2015. Exploration of the nicotinamide-binding site of the tankyrases, identifying 3-arylisoquinolin-1-ones as potent and selective inhibitors in vitro. Bioorganic and Medicinal Chemistry, 23 (17), pp. 5891-5908.
Twum, E. A., Nathubhai, A., Wood, P. J., Lloyd, M. D., Thompson, A. S. and Threadgill, M. D., 2015. Initial development of a cytotoxic amino-seco-CBI warhead for delivery by prodrug systems. Bioorganic and Medicinal Chemistry, 23 (13), pp. 3481-3489.
Kumpan, K., Nathubhai, A., Zhang, C., Wood, P. J., Lloyd, M. D., Thompson, A. S., Haikarainen, T., Lehtio, L. and Threadgill, M. D., 2015. Structure-based design, synthesis and evaluation in vitro of arylnaphthyridinones, arylpyridopyrimidinones and their tetrahydro derivatives as inhibitors of the tankyrases. Bioorganic and Medicinal Chemistry, 23, pp. 3013-3032.
Nathubhai, A., Wood, P. J., Lloyd, M. D., Thompson, A. S. and Threadgill, M. D., 2013. Design and discovery of 2‑arylquinazolin-4-ones as potent and selective inhibitors of tankyrases. ACS Medicinal Chemistry Letters, 4 (12), pp. 1173-1177.
Nathubhai, A., Patterson, R., Woodman, T. J., Sharp, H. E. C., Chui, M. T. Y., Chung, H. H. K., Lau, S. W. S., Zheng, J., Lloyd, M. D., Thompson, A. S. and Threadgill, M. D., 2011. N3-Alkylation during formation of quinazolin-4-ones from condensation of anthranilamides and orthoamides. Organic and Biomolecular Chemistry, 9 (17), pp. 6089-6099.
Dixon, M. J., Nathubhai, A., Andersen, O. A., van Aalten, D. M. F. and Eggleston, I. M., 2009. Solid-phase synthesis of cyclic peptide chitinase inhibitors: SAR of the argifin scaffold. Organic and Biomolecular Chemistry, 7 (2), pp. 259-268.
Dixon, M., Giuntini, F., Nathubhai, A., Andersen, O., van Aalten, D. and Eggleston, I., 2008. Synthetic approaches to cyclic peptide natural products as chitinase inhibitors. Journal of Peptide Science, 14 (8), p. 55.
Andersen, O. A., Nathubhai, A., Dixon, M. J., Eggleston, I. M. and van Aalten, D. M. F., 2008. Structure-based dissection of the natural product cyclopentapeptide chitinase inhibitor argifin. Chemistry & Biology, 15 (3), pp. 295-301.
Dixon, M., Nathubhai, A., Andersen, O., van Aalten, D. and Eggleston, I. M., 2008. Synthesis of cyclic peptide chitinase inhibitors:Natural products,with chemotherapeutic potential. Journal of Peptide Science, 14 (8 (Suppl S)), p. 13.
Dixon, M. J., Andersen, O. A., van Aalten, D. M. F., Nathubhai, A. and Eggleston, I. M., 2007. Cyclic peptide chitinase inhibitors: new leads for antifungal and anti-inflammatory drugs. Biopolymers, 88, p. 576.
Conference or Workshop Items
Jevglevskis, M., Lee, G. L., Nathubhai, A., James, T., Threadgill, M., Woodman, T. and Lloyd, M., 2017. A convenient colorimetric assay for α-methylacyl-CoA racemase (AMACR; P504S) and testing of inhibitors. In: 1st International Cancer Research @Bath symposium, 2017-04-20 - 2017-04-21, University of Bath.
Jevglevskis, M., Lee, G. L., Nathubhai, A., Petrova, Y., Threadgill, M., James, T., Woodman, T. and Lloyd, M., 2016. A Convenient Colorimetric Assay For Alpha-Methylacyl-CoA Racemase (AMACR; P504S) And Testing Of Inhibitors. In: RICT 2016 Interfacing Chemical Biology and Drug Discovery, 2016-07-06 - 2016-09-08.
Jevglevskis, M., Lee, G. L., Nathubhai, A., James, T., Threadgill, M., Woodman, T. and Lloyd, M., 2016. A convenient colorimetric assay for alpha-methylacyl-CoA racemase (AMACR; P504S) and testing for inhibitors.
Jevglevskis, M., Lee, G. L., Nathubhai, A., James, T., Threadgill, M., Woodman, T. and Lloyd, M., 2016. A Convenient Colorimetric Assay for α-Methylacyl-CoA Racemase (AMACR; P504S) and Testing Of Inhibitors. In: Cancer Research @ Bath 13th symposium, 2016-04-27 - 2016-04-27, University of Bath.
Jevglevskis, M., Lee, G. L., Nathubhai, A., James, T., Threadgill, M., Woodman, T. and Lloyd, M., 2015. A Convenient Colorimetric Assay for α-Methylacyl-CoA Racemase (AMACR; P504S) and Testing Of Inhibitors. In: Cancer Research @ Bath symposium, 2015-11-11 - 2015-11-11, University of Bath, Claverton Down cmpus, builidng 5W.
Kenny, M. B. C., Cheng, K. K. Y., Cheung, J. Y. C., Fung, S. K. M., Kumpan, E., Nathubhai, A. and Threadgill, M. D., 2015. Comparison of the inhibition of tankyrase-2 by 2-aryl-7,8-dihydrothiopyrano[4,3-d]pyrimidin-4-ones and 2-aryl-5,6,7,8-tetrahydroquinazolin-4-ones. In: 23rd Conference of the Groupement des Pharmacochimistes de l’Arc Atlantique (GP2A), 2015-08-26 - 2015-08-27.
Thesis
Nathubhai, A., 2010. Molecular probes for mammalian chitinases. Thesis (Doctor of Philosophy (PhD)). University of Bath.
Patent
Threadgill, M., Lloyd, M., Thompson, A., Nathubhai, A., Wood, P., Paine, H., Kumpan, E., Sunderland, P. and Woon, E. C. Y., 2014. Use of new and known pyridine or pyrimidine compounds, for the treatment of a disease or condition associated with tankyrase, e.g. cancer selected from e.g. breast, colon, stomach, and liver. WO2014087165-A1, 2014.
