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Items by Tosh, David

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Number of items: 81.

Wung, N., Acott, S. M., Tosh, D. and Ellis, M. J., 2014. Hollow fibre membrane bioreactors for tissue engineering applications. Biotechnology Letters

Ali Khan, M., Wood, P. J., Lamb-Guhren, N. M., Caggiano, L., Kociok-Köhn, G., Tosh, D. and Lewis, S. E., 2014. The enone motif of (+)-grandifloracin is not essential for 'anti-austerity' antiproliferative activity. Bioorganic & Medicinal Chemistry Letters, 24 (13), pp. 2815-2819.

Storm, M.P., Kumpfmueller, B., Bone, H.K., Buchholz, M., Sanchez Ripoll, Y., Chaudhuri, J.B., Niwa, H., Tosh, D. and Welham, M.J., 2014. Zscan4 is regulated by PI3-kinase and DNA-damaging agents and directly interacts with the transcriptional repressors LSD1 and CtBP2 in mouse embryonic stem cells. PLoS ONE, 9 (3).

Corbett, J.L. and Tosh, D., 2014. Conversion of one cell type into another : Implications for understanding organ development, pathogenesis of cancer and generating cells for therapy. Biochemical Society Transactions, 42 (3), pp. 609-616.

Corbett, J.L. and Tosh, D., 2014. Conversion of one cell type into another : Implications for understanding organ development, pathogenesis of cancer and generating cells for therapy. Biochemical Society Symposium, 81, pp. 609-616.

Gibson, M. K., Dhaliwal, A. S., Clemons, N. J., Phillips, W. A., Dvorak, K., Tong, D., Law, S., Pirchi, E. D., Rasanen, J., Krasna, M. J., Parikh, K., Krishnadath, K. K., Griffiths, L., Colleypriest, B. J., Farrant, J. M., Tosh, D., Das, K. M. and Bajpai, M., 2013. Barrett's esophagus : Cancer and molecular biology. Annals of the New York Academy of Sciences, 1300 (1), pp. 296-314.

Carter, E., Lau, C. Y., Tosh, D., Ward, S. G. and Mrsny, R. J., 2013. Cell penetrating peptides fail to induce an innate immune response in epithelial cells in vitro : Implications for continued therapeutic use. European Journal of Pharmaceutics and Biopharmaceutics, 85 (1), pp. 12-19.

Perán, M., Marchal, J. A., García, M. A., Kenyon, J. and Tosh, D., 2013. In vitro treatment of carcinoma cell lines with pancreatic (pro)enzymes suppresses the EMT programme and promotes cell differentiation. Cellular Oncology, 36 (4), pp. 289-301.

Burke, Z. D. and Tosh, D., 2012. Barrett's metaplasia as a paradigm for understanding the development of cancer. Current Opinion in Genetics & Development, 22 (5), pp. 494-499.

Burke, Z. D., Miron-Buchacra, G. and Tosh, D., 2012. Cellular Reprogramming During Mouse Development. In: Kubiak, J. Z., ed. Mouse Development. Berlin: Springer, pp. 291-302.

Tosh, D. and Horb, M. E., 2012. How cells change their phenotype. In: Atala, A. and Lanza, R., eds. Handbook of Stem Cells. Oxford, U. K.: Elsevier, pp. 95-100.

Burke, Z. D. and Tosh, D., 2012. Ontogenesis of Hepatic and Pancreatic Stem Cells. Stem Cell Reviews and Reports, 8 (2), pp. 586-596.

Bone, H. K., Nelson, A. S., Goldring, C. E., Tosh, D. and Welham, M. J., 2011. A novel chemically directed route for the generation of definitive endoderm from human embryonic stem cells based on inhibition of GSK-3. Journal of Cell Science, 124 (12), pp. 1992-2000.

Peran, M., Sanchez-Ferrero, A., Tosh, D., Marchal, J. A., Lopez, E., Alvarez, P., Boulaiz, H., Rodriguez-Serrano, F. and Aranega, A., 2011. Ultrastructural and molecular analyzes of insulin-producing cells induced from human hepatoma cells. Cytotherapy, 13 (2), pp. 193-200.

Sangan, C. B. and Tosh, D., 2010. Hepatic progenitor cells. Cell and Tissue Research, 342 (2), pp. 131-137.

Al-Adsani, A., Burke, Z. D., Eberhard, D., Lawrence, K. L., Shen, C. N., Rustgi, A. K., Sakaue, H., Farrant, J. M. and Tosh, D., 2010. Dexamethasone treatment induces the reprogramming of pancreatic acinar cells to hepatocytes and ductal cells. PLoS ONE, 5 (10), e13650.

Sangan, C. B. and Tosh, D., 2010. A new paradigm in cell therapy for diabetes: Turning pancreatic alpha-cells into beta-cells. Bioessays, 32 (10), pp. 881-884.

Wu, S. Y., Hsieh, C. C., Wu, R. R., Susanto, J., Liu, T. T., Shen, C. R., Chen, Y., Su, C. C., Chang, F. P., Chang, H. M., Tosh, D. and Shen, C. N., 2010. Differentiation of pancreatic acinar cells to hepatocytes requires an intermediate cell type. Gastroenterology, 138 (7), pp. 2519-2530.

Peran, M., Marchal, J. A., Lopez, E., Jimenez-Navarro, M., Boulaiz, H., Rodriguez-Serrano, F., Carrillo, E., Sanchez-Espin, G., De Teresa, E., Tosh, D. and Aranega, A., 2010. Human cardiac tissue induces transdifferentiation of adult stem cells towards cardiomyocytes. Cytotherapy, 12 (3), pp. 332-337.

Slack, J. M. W., Colleypriest, B. J., Quinlan, J. M., Yu, W. Y., Farrant, J. M. and Tosh, D., 2010. Barrett's metaplasia: molecular mechanisms and nutritional influences. Biochemical Society Transactions, 38 (2), pp. 313-319.

Yuill, K. H., Tosh, D. and Hancox, J. C., 2010. Streptozotocin-induced diabetes modulates action potentials and ion channel currents from the rat atrioventricular node. Experimental Physiology, 95 (4), pp. 508-517.

Colleypriest, B. J., Farrant, J. M., Slack, J. M. W. and Tosh, D., 2010. The role of Cdx2 in Barrett's metaplasia. Biochemical Society Transactions, 38 (2), pp. 364-369.

Buchert, M., Athineos, D., Abud, H. E., Burke, Z. D., Faux, M. C., Samuel, M. S., Jarnicki, A. G., Winbanks, C. E., Newton, I. P., Meniel, V. S., Suzuki, H., Stacker, S. A., Nathke, I. S., Tosh, D., Huelsken, J., Clarke, A. R., Heath, J. K., Sansom, O. J. and Ernst, M., 2010. Genetic dissection of differential signaling threshold requirements for the Wnt/β-Catenin pathway in vivo. Plos Genetics, 6 (1), e1000816.

Eberhard, D., O’Neill, K., Burke, Z. D. and Tosh, D., 2010. In vitro reprogramming of pancreatic cells to hepatocytes. In: Ding, S., ed. Cellular Programming and Reprogramming: Methods and Protocols.636 ed. Humana Press, pp. 285-292. (Methods in Molecular Biology)

Li, W.-C., Ralphs, K. L. and Tosh, D., 2010. Isolation and culture of adult mouse hepatocytes. In: Ward, A. and Tosh, D., eds. Mouse Cell Culture: Methods and Protocols.633 ed. Humana Press, pp. 185-196. (Methods in Molecular Biology)

Burke, Z. D., Li, W.-C., Slack, J. and Tosh, D., 2010. Isolation and culture of embryonic pancreas and liver. In: Ward, A. and Tosh, D., eds. Mouse Cell Culture: Methods and Protocols.633 ed. Humana Press, pp. 91-99. (Methods in Molecular Biology)

Quinian, J. M., Yu, W.-Y. and Tosh, D., 2010. Isolation, culture, and characterisation of mouse embryonic oesophagus and intestine. In: Ward, A. and Tosh, D., eds. Mouse Cell Culture: Methods and Protocols.633 ed. Humana Press, pp. 81-90. (Methods in Molecular Biology)

Ward, A. and Tosh, D., eds., 2010. Mouse Cell Culture: Methods and Protocols. Vol. 633. London: Humana Press. (Methods in Molecular Biology)

Colleypriest, B. J., Ward, S. G. and Tosh, D., 2009. How does inflammation cause Barrett's metaplasia? Current Opinion in Pharmacology, 9 (6), pp. 721-726.

Colleypriest, B. J., Palmer, R. M., Ward, S. G. and Tosh, D., 2009. Cdx genes, inflammation and the pathogenesis of Barrett's metaplasia. Trends in Molecular Medicine, 15 (7), pp. 313-322.

Saha, S., Tosh, D. and Hardikar, A. A., 2009. New sources of β-cells for treating diabetes. Journal of Endocrinology, 202 (1), pp. 13-16.

Burke, Z. D., Reed, K. R., Phesse, T. J., Sansom, O. J., Clarke, A. R. and Tosh, D., 2009. Liver zonation occurs through a β-catenin–dependent, c-Myc–independent mechanism. Gastroenterology, 136 (7), 2316-2324e3.

Sahu, S., Joglekar, M. V., Dumbre, R., Phadnis, S. M., Tosh, D. and Hardikar, A. A., 2009. Islet-like cell clusters occur naturally in human gall bladder and are retained in diabetic conditions. Journal of Cellular and Molecular Medicine, 13 (5), pp. 999-1000.

Sumitran-Holgersson, S., Nowak, G., Thowfeequ, S., Begum, S., Joshi, M., Jaksch, M., Kjaeldgaard, A., Jorns, C., Ericzon, B. G. and Tosh, D., 2009. Generation of hepatocyte-like cells from in vitro transdifferentiated human fetal pancreas. Cell Transplantation, 18 (2), pp. 183-193.

Coad, R. A., Dutton, J. R., Tosh, D. and Slack, J., 2009. Inhibition of Hes1 activity in gall bladder epithelial cells promotes insulin expression and glucose responsiveness. Biochemistry and Cell Biology - Biochimie Et Biologie Cellulaire, 87 (6), pp. 975-987.

Thowfeequ, S., Li, W.-C., Slack, J. M. and Tosh, D., 2009. Reprogramming of liver to pancreas. In: Audet, J. and Stanford, W. L., eds. Stem Cells in Regenerative Medicine.482 ed. Humana Press, pp. 407-418. (Methods in Molecular Biology)

Alliouachene, S., Tuttle, R. L., Boumard, S., Lapointe, T., Berissi, S., Germain, S., Jaubert, F., Tosh, D., Birnbaum, M. J. and Pende, M., 2008. Constitutively active Akt1 expression in mouse pancreas requires S6 kinase 1 for insulinoma formation. Journal of Clinical Investigation, 118 (11), pp. 3629-3638.

Pinto, J. P., Ribeiro, S., Pontes, H., Thowfeequ, S., Tosh, D., Carvalho, F. and Porto, G., 2008. Erythropoietin mediates hepcidin expression in hepatocytes through EPOR signaling and regulation of C/EBP alpha. Blood, 111 (12), pp. 5727-5733.

Eberhard, D. and Tosh, D., 2008. Transdifferentiation and metaplasia as a paradigm for understanding development and disease. Cellular and Molecular Life Sciences (CMLS), 65 (1), pp. 33-40.

O'Neill, K. E., Eberhard, D. and Tosh, D., 2008. Origin of beta-cells in regenerating pancreas. Bioessays, 30 (7), pp. 617-620.

Eberhard, D., Tosh, D. and Slack, J., 2008. Origin of pancreatic endocrine cells from biliary duct epithelium. Cellular and Molecular Life Sciences (CMLS), 65 (21), pp. 3467-3480.

Thowfeequ, S., Myatt, E.-J. and Tosh, D., 2007. Transdifferentiation in developmental biology, disease, and in therapy. Developmental Dynamics, 236 (12), pp. 3208-3217.

Thowfeequ, S., Dutton, J. R., Chillingworth, N. L., Eberhard, D., Tosh, D. and Slack, J. M. W., 2007. Organ switching - can we make beta cells from the liver? Xenotransplantation, 14 (5), p. 394.

Supriatna, Y., Kishimoto, T., Furuya, M., Tochigi, N., Ishiguro, H., Tosh, D. and Ishikura, H., 2007. Expression of liver-enriched nuclear factors and their isoforms in alpha-fetoprotein-producing gastric carcinoma cells. Experimental and Molecular Pathology, 82 (3), pp. 316-321.

Shen, C. N., Marguerie, A., Chien, C. Y., Dickson, C., Slack, J. M. W. and Tosh, D., 2007. All-trans retinoic acid suppresses exocrine differentiation and branching morphogenesis in the embryonic pancreas. Differentiation, 75 (1), pp. 62-74.

Thowfeequ, S., Ralphs, K. L., Yu, W. Y., Slack, J. M. W. and Tosh, D., 2007. Betacellulin inhibits amylase and glucagon production and promotes beta cell differentiation in mouse embryonic pancreas. Diabetologia, 50 (8), pp. 1688-1697.

Tosh, D., Shen, C. N., Alison, M. R., Sarraf, C. E. and Slack, J. M. W., 2007. Copper deprivation in rats induces islet hyperplasia and hepatic metaplasia in the pancreas. Biology of the Cell, 99 (1), pp. 37-44.

Quinlan, J. M., Colleypriest, B. J., Farrant, M. and Tosh, D., 2007. Epithelial metaplasia and the development of cancer. Biochimica Et Biophysica Acta-Reviews on Cancer, 1776 (1), pp. 10-21.

Jorns, C., Nowak, G., Thowfeequ, S., Begum, S., Ericzon, B. G., Tosh, D. and Sumitran-Holgersson, S., 2007. In Vitro expanded human fetal pancreatic cells differentiate into hepatocytes and cholangiocytes upon treatment with dexamethasone and functionally engraft the liver in a model of toxin-induced liver damage. Xenotransplantation, 14 (5), p. 437.

Li, W. C., Ralphs, K. L., Slack, J. and Tosh, D., 2007. Keratinoycyte serum-free medium maintains long term liver gene expression and function in cultured rat hepatocytes by preventing the loss of liver-enriched transcription factors. The International Journal of Biochemistry & Cell Biology, 39 (3), pp. 541-554.

Ralphs, K. L., Li, W.-C., Burke, Z. D., Thowfeequ, S., Al-Adsani, A. and Tosh, D., 2007. Sources of hepatocytes for transplantation in hepatic dysfunction. Journal of Organ Dysfunction, 3 (3), pp. 150-163.

Burke, Z. D., Thowfeequ, S., Peran, M. and Tosh, D., 2007. Stem cells in the adult pancreas and liver. Biochemical Journal, 404, pp. 169-178.

Dutton, J. R., Chillingworth, N. L., Eberhard, D., Brannon, C. R., Hornsey, M. A., Tosh, D. and Slack, J. M. W., 2007. β cells occur naturally in extrahepatic bile ducts of mice. Journal of Cell Science, 120 (2), pp. 239-245.

Burke, Z. D., Thowfeequ, S. and Tosh, D., 2006. Liver specification: A new role for Wnts in liver development. Current Biology, 16 (17), R688-R690.

Burke, Z. D. and Tosh, D., 2006. The Wnt/beta-catenin pathway: master regulator of liver zonation? Bioessays, 28 (11), pp. 1072-1077.

Quinlan, J., Yu, W.-Y., Hornsey, M., Tosh, D. and Slack, J., 2006. In vitro culture of embryonic mouse intestinal epithelium: cell differentiation and introduction of reporter genes. BMC Developmental Biology, 6 (24).

Quinlan, J. M., Yu, W. Y., Hornsey, M. A., Tosh, D. and Slack, J. M. W., 2006. In vitro culture of embryonic mouse intestinal epithelium: cell differentiation and introduction of reporter genes. BMC Developmental Biology, 6, 24.

Burke, Z. D., Shen, C. N., Ralphs, K. L. and Tosh, D., 2006. Characterization of liver function in transdifferentiated hepatocytes. Journal of Cellular Physiology, 206 (1), pp. 147-159.

Westmacott, A., Burke, Z. D., Oliver, G., Slack, J. M. W. and Tosh, D., 2006. C/EBP alpha and C/EBP beta are markers of early liver development. International Journal of Developmental Biology, 50 (7), pp. 653-657.

Tosh, D., 2006. Differentiation of pancreatic cells into hepatocytes. In: Celis, J. E., ed. Cell Biology: A Laboratory Handbook. Vol. 1. 3rd ed. Burlington, Mass.: Elsevier, pp. 177-182.

Yu, W. Y., Slack, J. M. W. and Tosh, D., 2005. Conversion of columnar to stratified squamous epithelium in the developing mouse oesophagus. Developmental Biology, 284 (1), pp. 157-170.

Li, W. C., Yu, W. Y., Quinlan, J. M., Burke, Z. D. and Tosh, D., 2005. The molecular basis of transdifferentiation. Journal of Cellular and Molecular Medicine, 9 (3), pp. 569-582.

Li, W. C., Horb, M. E., Tosh, D. and Slack, J. M. W., 2005. In vitro transdifferentiation of hepatoma cells into functional pancreatic cells. Mechanisms of Development, 122 (6), pp. 835-847.

Tosh, D. and Strain, A., 2005. Liver stem cells - prospects for clinical use. Journal of Hepatology, 42 (1 Supp 1), S75-S84.

Wang, R. Y. L., Shen, C. N., Lin, M. H., Tosh, D. and Shih, C. H., 2005. Hepatocyte-like cells transdifferentiated from a pancreatic origin can support replication of hepatitis B virus. Journal of Virology, 79 (20), pp. 13116-13128.

Burke, Z. D. and Tosh, D., 2005. Therapeutic potential of transdifferentiated cells. Clinical Science, 108 (4), pp. 309-321.

Shen, C.-N., Z D, B. and Tosh, D., 2004. Transdifferentiation, metaplasia and tissue regeneration. Organogenesis, 1 (2), pp. 36-44.

Martin, H. M., Moore, K. P., Bosmans, E., Davies, S., Burroughs, A. K., Dhillon, A. P., Tosh, D. and Harrison, R., 2004. Xanthine oxidoreductase is present in bile ducts of normal and cirrhotic liver. Free Radical Biology and Medicine, 37 (8), pp. 1214-1223.

Burke, Z. D., Shen, C. N. and Tosh, D., 2004. Bile ducts as a source of pancreatic beta cells. Bioessays, 26 (9), pp. 932-937.

Kurash, J. K., Shen, C. N. and Tosh, D., 2004. Induction and regulation of acute phase proteins in transdifferentiated hepatocytes. Experimental Cell Research, 292 (2), pp. 342-358.

Slack, J., Horb, M. and Tosh, D., 2003. Transdifferentiation of Cells and Tissues. C07K14/035-WO03078636 (A1), 25 September 2003.

Horb, M. E., Shen, C. N., Tosh, D. and Slack, J. M. W., 2003. Experimental conversion of liver to pancreas. Current Biology, 13 (2), pp. 105-115.

Shen, C. N., Horb, M. E., Slack, J. M. W. and Tosh, D., 2003. Transdifferentiation of pancreas to liver. Mechanisms of Development, 120 (1), pp. 107-116.

Shen, C. N., Seckl, J. R., Slack, J. M. W. and Tosh, D., 2003. Glucocorticoids suppress beta-cell development and induce hepatic metaplasia in embryonic pancreas. Biochemical Journal, 375, pp. 41-50.

Tosh, D., Shen, C. N. and Slack, J. M. W., 2002. Differentiated properties of hepatocytes induced from pancreatic cells. Hepatology, 36 (3), pp. 534-543.

Tosh, D. and Slack, J. M. W., 2002. How cells change their phenotype. Nature Reviews Molecular Cell Biology, 3 (3), pp. 187-194.

Jones, E. A., Tosh, D., Wilson, D. I., Lindsay, S. and Forrester, L. M., 2002. Hepatic differentiation of murine embryonic stem cells. Experimental Cell Research, 272 (1), pp. 15-22.

Tosh, D., Shen, C. N. and Slack, J. M. W., 2002. Conversion of pancreatic cells to hepatocytes. Biochemical Society Transactions, 30 (2), pp. 51-54.

Shen, C. N., Slack, J. M. W. and Tosh, D., 2000. Molecular basis of transdifferentiation of pancreas to liver. Nature Cell Biology, 2 (12), pp. 879-887.

Pryor, P. R., Liu, S. C. H., Clark, A. E., Yang, J., Holman, G. D. and Tosh, D., 2000. Chronic insulin effects on insulin signalling and GLUT4 endocytosis are reversed by metformin. Biochemical Journal, 348 (1), pp. 83-91.

Malide, D., Tosh, D., Clark, A. E., Cushman, S. W. and Holman, G. D., 1996. Altered GLUT4 subcellular trafficking in primary adipose cell cultures: Immunocytochemical evidence. Molecular Biology of the Cell, 7, p. 2636.

This list was generated on Tue Oct 21 14:49:37 2014 IST.