Items by Woo, Lok

Woo, L. W. L., Leblond, B., Purohit, A. and Potter, B. V. L., 2012. Synthesis and evaluation of analogues of estrone-3-O-sulfamate as potent steroid sulfatase inhibitors. Bioorganic and Medicinal Chemistry, 20 (8), pp. 2506-2519.

Woo, L. W. L., Ganeshapillai, D., Thomas, M. P., Sutcliffe, O. B., Malini, B., Mahon, M. F., Purohit, A. and Potter, B. V. L., 2011. Structure-activity relationship for the first-in-class clinical steroid sulfatase inhibitor irosustat (STX64, BN83495). ChemMedChem, 6 (11), pp. 2019-2034.

Wood, P. M., Woo, L. W. L., Thomas, M. P., Mahon, M. F., Purohit, A. and Potter, B. V. L., 2011. Aromatase and dual aromatase-steroid sulfatase inhibitors from the letrozole and vorozole templates. ChemMedChem, 6 (8), pp. 1423-1438.

Woo, L. W. L., Purohit, A. and Potter, B. V. L., 2011. Development of steroid sulfatase inhibitors. Molecular and Cellular Endocrinology, 340 (2), pp. 175-185.

Purohit, A., Woo, L. W. L. and Potter, B. V. L., 2011. Steroid sulfatase : a pivotal player in estrogen synthesis and metabolism. Molecular and Cellular Endocrinology, 340 (2), pp. 154-160.

Woo, L. W. L., Bubert, C., Purohit, A. and Potter, B. V. L., 2011. Hybrid dual aromatase-steroid sulfatase inhibitors with exquisite picomolar inhibitory activity. ACS Medicinal Chemistry Letters, 2 (3), pp. 243-247.

Wood, P. M., Woo, L. W. L., Labrosse, J.-R., Thomas, M. P., Mahon, M. F., Chander, S. K., Purohit, A., Reed, M. J. and Potter, B. V. L., 2010. Bicyclic derivatives of the potent dual aromatase-steroid sulfatase inhibitor 2-bromo-4-{ (4-cyanophenyl)(4H-1,2,4-triazol-4-yl)amino methyl}phenylsul famate : synthesis, SAR, crystal structure, and in vitro and in vivo activities. ChemMedChem, 5 (9), pp. 1577-1593.

Woo, L. .W. L., Jackson, T., Putey, A., Cozier, G., Leonard, P., Acharya, K. R., Chander, S. K., Purohit, A., Reed, M. J. and Potter, B. V. L., 2010. Highly potent first examples of dual aromatase-steroid sulfatase inhibitors based on a biphenyl template. Journal of Medicinal Chemistry, 53 (5), pp. 2155-2170.

Abbate, S., Longhi, G., Castiglioni, E., Lebon, F., Wood, P. M., Woo, L. W. L. and Potter, B. V. L., 2009. Determination of the absolute configuration of aromatase and dual aromatase-sulfatase inhibitors by vibrational and electronic circular dichroism spectra analysis. Chirality, 21 (9), pp. 802-808.

Foster, P. A., Chander, S. K., Newman, S. P., Woo, L. W. L., Sutcliffe, O. B., Bubert, C., Zhou, D. J., Chen, S. A., Potter, B. V. L., Reed, M. J. and Purohit, A., 2008. A new therapeutic strategy against hormone-dependent breast cancer : the preclinical development of a dual aromatase and sulfatase inhibitor. Clinical Cancer Research, 14 (20), pp. 6469-6477.

Bubert, C., Woo, L. W. L., Sutcliffe, O. B., Mahon, M. F., Chander, S. K., Purohit, A., Reed, M. J. and Potter, B. V. L., 2008. Synthesis of aromatase inhibitors and dual aromatase steroid sulfatase inhibitors by linking an arylsulfamate motif to 4-(4H-1,2,4-triazol-4-ylamino)benzonitrile : SAR, crystal structures, in vitro and in vivo activities. ChemMedChem, 3 (11), pp. 1708-1730.

Reed, M. J., Purohit, A., Woo, L. W. L. and Potter, B. V. L., 2008. Steroid sulfatase inhibitors for the tropical treatment of skin disorders. Drugs of the Future, 33 (7), pp. 597-606.

Fusi, L., Purohit, A., Brosens, J., Woo, L. W. L., Potter, B. V. L. and Reed, M. J., 2008. Inhibition of steroid sulfatase activity in endometriotic Implants by STX64 (667Coumate) : a potential new therapy. The Scientific World Journal, 8, pp. 1325-1327.

Woo, L. W. L., Fischer, D. S., Sharland, C. M., Trusselle, M., Foster, P. A., Chander, S. K., Di Fiore, A., Supuran, C. T., De Simone, G., Purohit, A., Reed, M. J. and Potter, B. V. L., 2008. Anticancer steroid sulfatase inhibitors : synthesis of a potent fluorinated second-generation agent, in vitro and in vivo activities, molecular modeling, and protein crystallography. Molecular Cancer Therapeutics, 7 (8), pp. 2435-2444.

Wood, P. M., Woo, L. W. L., Labrosse, J.-R., Trusselle, M. N., Abbate, S., Longhi, G., Castiglioni, E., Lebon, F., Purohit, A., Reed, M. J. and Potter, B. V. L., 2008. Chiral aromatase and dual aromatase−steroid sulfatase inhibitors from the letrozole template : synthesis, absolute configuration, and in vitro activity. Journal of Medicinal Chemistry, 51 (14), pp. 4226-4238.

Bojarová, P., Denehy, E., Walker, I., Loft, K., De Souza, D. P., Woo, L. W. L., Potter, B. V. L., McConville, M. J. and Williams, S. J., 2008. Direct evidence for ArO-S bond cleavage upon inactivation of Pseudomonas aeruginosa Arylsulfatase by Aryl Sulfamates. ChemBiochem, 9 (4), pp. 613-623.

Foster, P. A., Chander, S. K., Parsons, M. F. C., Newman, S. P., Woo, L. W. L., Potter, B. V. L., Reed, M. J. and Purohit, A., 2008. Efficacy of three potent steroid sulfatase inhibitors : pre-clinical investigations for their use in the treatment of hormone-dependent breast cancer. Breast Cancer Research and Treatment, 111 (1), pp. 129-138.

Purohit, A., Fusi, L., Brosens, J., Woo, L. W. L., Potter, B. V. L. and Reed, M. J., 2008. Inhibition of steroid sulfatase activity in endometriotic implants by (667Coumate) : a potential new therapy. Human Reproduction, 23 (2), pp. 290-297.

Purohit, A., Chander, S. K., Woo, L. W. L., Parsons, M. F. C., Jhalli, R., Potter, B. V. L. and Reed, M. J., 2008. Inhibition of steroid sulphatase activity via the percutaneous route : a new option for breast cancer therapy. Anticancer Research, 28 (3A), pp. 1517-1523.

Jackson, T., Woo, L. W. L., Trusselle, M. N., Purohit, A., Reed, M. J. and Potter, B. V. L., 2008. Non-steroidal aromatase inhibitors based ona biphenyl scaffold: synthesis, in vitro SAR, and molecular modelling. ChemMedChem, 3, pp. 603-618.

Foster, P. A., Woo, L. W. L., Potter, B. V. L., Reed, M. J. and Purohit, A., 2008. The use of steroid sulfatase inhibitors as a novel therapeutic strategy against hormone-dependent endometrial cancer. Endocrinology, 149 (8), pp. 4035-4042.

Woo, L. W. L., Bubert, C., Sutcliffe, O. B., Smith, A., Chander, S. K., Mahon, M. F., Purohit, A., Reed, M. J. and Potter, B. V. L., 2007. Dual aromatase-steroid sulfatase inhibitors. Journal of Medicinal Chemistry, 50 (15), pp. 3540-3560.

Jackson, T., Woo, L. W. L., Trusselle, M. N., Chander, S. K., Purohit, A., Reed, M. J. and Potter, B. V. L., 2007. Dual aromatase-sulfatase inhibitors based on the anastrozole template : synthesis, in vitro SAR, molecular modelling and in vivo activity. Organic and Biomolecular Chemistry, 5, pp. 2940-2952.

Stanway, S. J., Delavault, P., Purohit, A., Woo, L. W. L., Thurieau, C., Potter, B. V. L. and Reed, M. J., 2007. Steroid sulfatase : a new target for the endocrine therapy of breast cancer. The Oncologist, 12 (4), pp. 370-374.

Stanway, S. J., Purohit, A., Woo, L. W. L., Sufi, S., Vigushin, D., Ward, R., Wilson, R. H., Stanczyk, F. Z., Dobbs, N., Kulinskaya, E., Elliott, M., Potter, B. V. L., Reed, M. J. and Coombes, R. C., 2006. Phase I study of STX 64 (667 Coumate) in breast cancer patients: the first study of a steroid sulfatase inhibitor. Clinical Cancer Research, 12 (5), pp. 1585-1592.

Foster, P. A., Newman, S. P., Chander, S. K., Stengel, C., Jhalli, R., Woo, L. L. W., Potter, B. V. L., Reed, M. J. and Purohit, A., 2006. In vivo efficacy of STX213, a second-generation steroid sulfatase inhibitor, for hormone-dependent breast cancer therapy. Clinical Cancer Research, 12 (18), pp. 5543-5549.

Reed, M. J., Purohit, A., Woo, L. W. L., Newman, S. P. and Potter, B. V. L., 2005. Steroid sulfatase : molecular biology, regulation, and inhibition. Endocrine Reviews, 26 (2), pp. 171-202.

Wood, P. M., Woo, L. W. L., Humphreys, A., Chander, S. K., Purohit, A., Reed, M. J. and Potter, B. V. L., 2005. A Letrozole-based dual aromatase-sulphatase inhibitor with in vivo activity. Steroid Biochemistry & Molecular Biology, 94 (1-3), pp. 123-130.

Lloyd, M. D., Pederick, R. L., Natesh, R., Woo, L. W. L., Purohit, A., Reed, M. J., Acharya, R. and Potter, B. V. L., 2005. Crystal structure of human carbonic anhydrase II at 1.95 Å resolution in complex with 667-coumate, a novel anti-cancer agent. Biochemical Journal, 385 (Pt 3), pp. 715-720.

Lloyd, M. D., Thiyagarajan, N., Ho, Y. T., Woo, L. W. L., Sutcliffe, O. B., Purohit, A., Reed, M. J., Acharya, K. R. and Potter, B. V. L., 2005. First crystal structures of human carbonic anhydrase II in complex with dual aromatase-steroid sulfatase inhibitors. Biochemistry, 44 (18), pp. 6858-6866.

Reed, J. E., Woo, L. W. L., Robinson, J. J., Leblond, B., Leese, M. P., Purohit, A., Reed, M. J. and Potter, B. V. L., 2004. 2-Difluoromethyloestrone 3-0-sulphamate, a highly potent steroid sulphatase inhibitor. Biochemical and Biophysical Research Communications, 317 (1), pp. 169-175.

Ireson, C. R., Chander, S. K., Purohit, A., Parish, D. C., Woo, L. W. L., Potter, B. V. L. and Reed, M. J., 2004. Pharmacokinetics of the nonsteroidal sulphatase inhibitor 667 COUMATE and its sequestration into red blood cells in rats. British Journal of Cancer, 91 (7), pp. 1399-1404.

Hejaz, H. A. M., Woo, L. W. L., Purohit, A., Reed, M. J. and Potter, B. V. L., 2004. Synthesis, in vitro and in vivo activity of benzophenone-based inhibitors of steroid sulfatase. Bioorganic and Medicinal Chemistry, 12 (10), pp. 2759-2772.

Chander, S. K., Purohit, A., Woo, L. W. L., Potter, B. V. L. and Reed, M. J., 2004. The role of steroid suophatase in regulating the oestrogenicity of oestrogen sulphamates. Biochemical and Biophysical Research Communications, 322 (1), pp. 217-222.

Fischer, D. S., Woo, L. W. L., Mahon, M. F., Purohit, A., Reed, M. J. and Potter, B. V. L., 2003. D-ring modified estrone derivatives as novel potent inhibitors of steroid sulfatase. Bioorganic and Medicinal Chemistry, 11 (8), pp. 1685-1700.

Ireson, C. R., Parish, D., Purohit, A., Woo, L. W. L., Potter, B. V. L., Chander, S. K. and Reed, M. J., 2003. Development of a sensitive high-performance liquid chromatography method for the detection of 667 COUMATE in vivo. Journal of Steroid Biochemistry and Molecular Biology, 84 (2), pp. 337-342.

Vicker, N., Ho, Y., Robinson, J., Woo, L. W. L., Purohit, A., Reed, M. J. and Potter, B. V. L., 2003. Docking studies of sulphamate inhibitors of estrone sulphatase in human carbonic anhydrase II. Bioorganic & Medicinal Chemistry Letters, 13 (5), pp. 863-865.

Woo, L. W. L., Sutcliffe, O. B., Bubert, C., Grasso, A., Chander, S., Purohit, A., Reed, M. J. and Potter, B. V. L., 2003. First dual aromatase-steroid sulfatase inhibitor. Journal of Medicinal Chemistry, 46 (15), pp. 3193-3196.

Raobaikady, B., Purohit, A., Chander, S. K., Woo, L. W. L., Leese, M. P., Potter, B. V. L. and Reed, M. J., 2003. Inhibition of MCF-7 breast cancer cell proliferation and in vivo steroid sulphatase activity by 2-methoxyoestradiol-bis-sulphamate. Steroid Biochemistry & Molecular Biology, 84 (2), pp. 351-358.

Fischer, D. S., Chander, S. K., Woo, L. W. L., Fenton, J. C., Purohit, A., Reed, M. J. and Potter, B. V. L., 2003. Novel D-ring modified steroid derivatives as potent, non-estrogenic steroid sulfatase inhibitors with in vivo activity. Steroid Biochemistry & Molecular Biology, 84 (2-3), pp. 343-349.

Purohit, A., Woo, L. W. L., Chander, S. K., Newman, S. P., Ireson, C., Ho, Y., Grasso, A., Leese, M. P., Potter, B. V. L. and Reed, M. J., 2003. Steroid sulphatase inhibitors for breast cancer therapy. Steroid Biochemistry & Molecular Biology, 86 (3), pp. 423-432.

Wood, L., Leese, M. P., Leblond, B., Woo, L. W. L., Ganeshapillai, D., Purohit, A., Reed, M. J., Potter, B. V. L. and Packham, G., 2002. Inhibition of superoxide dismutase by 2-methoxyoestradiol analogues and oestrogen derivatives: structure-activity relationships. Anti-Cancer Drug Design, 16 (4), pp. 209-215.

Purohit, A., Woo, L. W. L., Barrow, D., Hejaz, H. A. M., Nicholson, R. I., Potter, B. V. L. and Reed, M. J., 2001. Non-steroidal and steroidal sulfamates : new drugs for cancer therapy. Molecular and Cellular Endocrinology, 171 (1-2), pp. 129-135.

Woo, L. W. L., Purohit, A., Malini, B., Reed, M. J. and Potter, B. V. L., 2000. Potent active site-directed inhibition of steroid sulphatase by tricyclic coumarin-based sulphamates. Chemistry & Biology, 7 (10), pp. 773-791.

Purohit, A., Hejaz, H. A. M., Woo, L. W. L., Van Strien, A. E., Potter, B. V. L. and Reed, M. J., 1999. Recent advances in the development of steroid sulphatase inhibitors. Steroid Biochemistry & Molecular Biology, 69 (1-6), pp. 227-238.

Woo, L. W. L., Howarth, N. M., Purohit, A., Hejaz, H. A. M., Reed, M. J. and Potter, B. V. L., 1998. Steroidal and nonsteroidal sulfamates as potent inhibitors of steroid sulfatase. Journal of Medicinal Chemistry, 41 (7), pp. 1068-1083.

Purohit, A., Vernon, K. A., Wagenaar Hummelinck, A. E., Woo, L. W. L., Hejaz, H. A. M., Potter, B. V. L. and Reed, M. J., 1998. The development of A-ring modified analogues of oestrone-3-O-sulphamate as potent steroid sulphatase inhibitors with reduced oestrogenicity. Steroid Biochemistry & Molecular Biology, 64 (5-6), pp. 269-275.

Woo, L. W. L., Purohit, A., Reed, M. J. and Potter, B. V. L., 1997. Oestrone 3-O-(N-acetyl)sulphamate, a potential molecular probe of the active site of oestrone sulphatase. Bioorganic & Medicinal Chemistry Letters, 7 (24), pp. 3075-3080.

Purohit, A., Woo, L. W. L., Singh, A., Winterborn, C. J., Potter, B. V. L. and Reed, M. J., 1996. In vivo activity of 4-methyl coumarin 7-0-sulfamate : a non-steroidal non-estrogenic steroid sulfatase inhibitor. Cancer Research, 56 (21), pp. 4950-4955.

Reed, M. J., Purohit, A., Woo, L. W. L. and Potter, B. V. L., 1996. The development of steroid sulphatase inhibitors. Endocrine-Related Cancer, 3 (1), pp. 9-23.

Woo, L. W. L., Purohit, A., Reed, M. J. and Potter, B. V. L., 1996. Active site directed inhibition of estrone sulfatase by nonsteroidal coumarin sulfamates. Journal of Medicinal Chemistry, 39 (7), pp. 1349-1351.

Woo, L. W. L., Lightowler, M., Purohit, A., Reed, M. J. and Potter, B. V. L., 1996. Heteroatom-substituted analogues of the active-site directed inhibitor estra-1,3,5(10)-trien-17-one-3-sulphamate inhibit estrone sulphatase by a different mechanism. Steroid Biochemistry & Molecular Biology, 57 (1-2), pp. 79-88.