Items by Hough, David

Marrott, N. L., Marshall, J. J. T., Svergun, D. I., Crennell, S. J., Hough, D. W., Danson, M. J. and van den Elsen, J. M. H., 2012. The catalytic core of an archaeal 2-oxoacid dehydrogenase multienzyme complex is a 42-mer protein assembly. FEBS Journal, 279 (5), pp. 713-723.

Moore, V., Kanu, A., Byron, O., Campbell, G., Danson, M. J., Hough, D. W. and Crennell, S. J., 2011. Contribution of inter-subunit interactions to the thermostability of Pyrococcus furiosus citrate synthase. Extremophiles, 15 (3), pp. 327-336.

Nunn, C. E. M., Johnsen, U., Schonheit, P., Fuhrer, T., Sauer, U., Hough, D. W. and Danson, M. J., 2010. Metabolism of pentose sugars in the hyperthermophilic archaea sulfolobus solfataricus and sulfolobus acidocaldarius. Journal of Biological Chemistry, 285 (44), pp. 33701-33709.

Royer, S. F., Haslett, L., Crennell, S. J., Hough, D. W., Danson, M. J. and Bull, S. D., 2010. Structurally informed site-directed mutagenesis of a stereochemically promiscuous aldolase to afford stereochemically complementary biocatalysts. Journal of the American Chemical Society, 132 (33), pp. 11753-11758.

Payne, K. A. P., Hough, D. W. and Danson, M. J., 2010. Discovery of a putative acetoin dehydrogenase complex in the hyperthermophilic archaeon Sulfolobus solfataricus. FEBS Letters, 584 (6), pp. 1231-1234.

Posner, M. G., Upadhyay, A., Bagby, S., Hough, D. W. and Danson, M. J., 2009. A unique lipoylation system in the Archaea: lipoylation in Thermoplasma acidophilum requires two proteins. FEBS Journal, 276 (15), pp. 4012-4022.

Emptage, C. D., Knox, R. J., Danson, M. J. and Hough, D. W., 2009. Nitroreductase from Bacillus licheniformis:a stable enzyme for prodrug activation. Biochemical Pharmacology, 77 (1), pp. 21-29.

Bull, S. D., Danson, M. J., Hough, D. W. and Royer, S., 2009. Engineering stereocontrol into aldolase catalyzed reactions. Abstracts of Papers of the American Chemical Society, 238, 23-ORGN.

Daniel, R. M., Danson, M. J., Hough, D. W., Lee, C. K., Peterson, M. E. and Cowan, D. A., 2008. Enzyme stability and activity at high temperatures. In: Siddiqui, K. S. and Thomas, T., eds. Protein Adaptation in Extremophiles. New York, U. S. A.: Nova Science, pp. 1-34.

Al-Mailem, D. M., Hough, D. W. and Danson, M. J., 2008. The 2-oxoacid dehydrogenase multienzyme complex of Haloferax volcanii. Extremophiles, 12 (1), pp. 89-96.

Potter, J. A., Kerou, M., Lamble, H. J., Bull, S. D., Hough, D. W., Danson, M. J. and Taylor, G. L., 2008. The structure of Sulfolobus solfataricus 2-keto-3-deoxygluconate kinase. Acta Crystallographica Section D-Biological Crystallography, 64, pp. 1283-1287.

Lamble, H. J., Royer, S. F., Hough, D. W., Danson, M. J., Taylor, G. L. and Bull, S. D., 2007. A thermostable aldolase for the synthesis of 3-deoxy-2-ulosonic acids. Advanced Synthesis & Catalysis, 349 (6), pp. 817-821.

Eisenthal, R., Danson, M. J. and Hough, D. W., 2007. Catalytic efficiency and k(cat)/K-M: a useful comparator? Trends in Biotechnology, 25 (6), pp. 247-249.

Danson, M. J., Lamble, H. J. and Hough, D. W., 2007. Central metabolism. In: Cavicchioli, R., ed. Archaea: Molecular and Cellular Biology. Washington DC: ASM Press, pp. 260-287.

Heath, C., Posner, M. G., Aass, H. C., Upadhyay, A., Scott, D. J., Hough, D. W. and Danson, M. J., 2007. The 2-oxoacid dehydrogenase multi-enzyme complex of the archaeon Thermoplasma acidophilum - recombinant expression, assembly and characterization. FEBS Journal, 274 (20), pp. 5406-5415.

Milburn, C. C., Lamble, H. J., Theodossis, A., Bull, S. D., Hough, D. W., Danson, M. J. and Taylor, G. L., 2006. The structural basis of substrate promiscuity in glucose dehydrogenase from the hyperthermophilic archaeon Sulfolobus solfataricus. Journal of Biological Chemistry, 281 (21), pp. 14796-14804.

Lamble, H. J., Theodossis, A., Milburn, C. C., Taylor, G. L., Bull, S., Hough, D. W. and Danson, M. J., 2005. Promiscuity in the part-phosphorylative Entner-Doudoroff pathway of the archaeon Sulfolobus solfataricus. FEBS Letters, 579 (30), pp. 6865-6869.

Lamble, H. J., Danson, M. J., Hough, D. W. and Bull, S. D., 2005. Engineering stereocontrol into an aldolase-catalysed reaction. Chemical Communications, 2005 (1), pp. 124-126.

Theodossis, A., Milburn, C. C., Heyer, N. I., Lamble, H. J., Hough, D. W., Danson, M. J. and Taylor, G., 2005. Preliminary crystallographic studies of glucose dehydrogenase from the promiscuous Entner-Doudoroff pathway in the hyperthermophilic archaeon Sulfolobus solfataricus. Acta Crystallographica Section F-Structural Biology and Crystallization Communications, 61, pp. 112-115.

Danson, M. J. and Hough, D. W., 2005. Promiscuity in the Archaea. The enzymology of metabolic pathways. The Biochemist, 27, pp. 17-21.

Heath, C., Jeffries, A. C., Hough, D. W. and Danson, M. J., 2004. Discovery of the catalytic function of a putative 2-oxoacid dehydrogenase multienzyme complex in the thermophilic archaeon Thermoplasma acidophilum. FEBS Letters, 577 (3), pp. 523-527.

Lamble, F. J., Milburn, C. C., Taylor, G. L., Hough, D. W. and Danson, M. J., 2004. Gluconate dehydratase from the promiscuous Entner-Doudoroff pathway in Sulfolobus solfataricus. FEBS Letters, 576 (1-2), pp. 133-136.

Danson, M. J., Morgan, D. J., Jeffries, A. C., Hough, D. W. and Dyall-Smith, M. L., 2004. Multienzyme complexes in the Archaea: predictions from genome sequences. In: Ventosa, A., ed. Halophilic Microorganisms. Springer-Verlag, pp. 177-191.

Theodossis, A., Walden, H., Westwick, E. J., Connaris, H., Lamble, H. J., Hough, D. W., Danson, M. J. and Taylor, G. L., 2004. The structural basis for substrate promiscuity in 2-keto-3-deoxygluconate aldolase from the Entner-Doudoroff pathway in Sulfolobus solfataricus. Journal of Biological Chemistry, 279 (42), pp. 43886-43892.

Karlsson, E. N., Crennell, S. J., Higgins, C., Nawaz, S., Yeoh, L., Hough, D. W. and Danson, M. J., 2003. Citrate synthase from Thermus aquaticus: a thermostable bacterial enzyme with a five-membered inter-subunit ionic network. Extremophiles, 7 (1), pp. 9-16.

Lamble, H. J., Heyer, N. I., Bull, S. D., Hough, D. W. and Danson, M. J., 2003. Metabolic pathway promiscuity in the Archaeon Sulfolobus solfataricus revealed by studies on glucose dehydrogenase and 2-keto-3-deoxygluconate aldolase. Journal of Biological Chemistry, 278 (36), pp. 34066-34072.

Wery, N., Gerike, U., Sharman, A., Chaudhuri, J. B., Hough, D. W. and Danson, M. J., 2003. Use of a packed-column bioreactor for isolation of diverse protease-producing bacteria from antarctic soil. Applied and Environmental Microbiology, 69 (3), pp. 1457-1464.

Karlsson, E. N., Abou-Hachem, M., Holst, O., Danson, M. J. and Hough, D. W., 2002. Rhodothermus marinus: a thermophilic bacterium producing dimeric and hexameric citrate synthase isoenzymes. Extremophiles, 6 (1), pp. 51-56.

Bell, G. S., Russell, R. J. M., Connaris, H., Hough, D. W., Danson, M. J. and Taylor, G. L., 2002. Stepwise adaptations of citrate synthase to survival at life's extremes - From psychrophile to hyperthermophile. European Journal of Biochemistry, 269 (24), pp. 6250-6260.

Danson, M. J. and Hough, D. W., 2001. Citrate synthase from hyperthermophilic archaea. In: Adams, M. W. W. and Kelly, R., eds. Methods in Enzymology: Hyperthermophilic Enzymes Part B. Vol. 331. Academic Press, pp. 3-12. (Methods in Enzymology)

Gerike, U., Danson, M. J. and Hough, D. W., 2001. Cold-active citrate synthase: mutagenesis of active-site residues. Protein Engineering, 14 (9), pp. 655-661.

Jolley, K. A., Maddocks, D. G., Gyles, S. L., Mullan, Z., Tang, S. L., Dyall-Smith, M. L., Hough, D. W. and Danson, M. J., 2000. 2-Oxoacid dehydrogenase multienzyme complexes in the halophilic Archaea ? Gene sequences and protein structural predictions. Microbiology, 146, pp. 1061-1069.

Atkinson, T., Gairns, S., Cowan, D. A., Danson, M. J., Hough, D. W., Johnson, D. B., Norris, P. R., Raven, N., Robinson, C., Robson, R. and Sharp, R. J., 2000. A microbiological survey of Montserrat Island hydrothermal biotopes. Extremophiles, 4 (5), pp. 305-313.

Ng, W. V., Kennedy, S. P., Mahairas, G. G., Berquist, B., Pan, M., Shukla, H. D., Lasky, S. R., Baliga, N. S., Thorsson, V., Sbrogna, J., Swartzell, S., Weir, D., Hall, J., Dahl, T. A., Welti, R., Goo, Y. A., Leithauser, B., Keller, K., Cruz, R., Danson, M. J., Hough, D. W., Maddocks, D. G., Jablonski, P. E., Krebs, M. P., Angevine, C. M., Dale, H., Isenbarger, T. A., Peck, R. F., Pohlschroder, M., Spudich, J. L., Jung, K. H., Alam, M., Freitas, T., Hou, S. B., Daniels, C. J., Dennis, P. P., Omer, A. D., Ebhardt, H., Lowe, T. M., Liang, R., Riley, M., Hood, L. and DasSarma, S., 2000. Genome sequence of Halobacterium species NRC-1. Proceedings of the National Academy of Sciences of the United States of America, 97 (22), pp. 12176-12181.

Pire, C., Camacho, M. L., Ferrer, J., Hough, D. W. and Bonete, M. J., 2000. NAD(P)(+)-glucose dehydrogenase from Haloferax mediterranei: kinetic mechanism and metal content. Journal of Molecular Catalysis B: Enzymatic, 10 (4), pp. 409-417.

Hendry, E. J., Buchanan, C. L., Russell, R. J. M., Hough, D. W., Reeve, C. D., Danson, M. J. and Taylor, G. L., 2000. Preliminary crystallographic studies of an extremely thermostable KDG aldolase from Sulfolobus solfataricus. Acta Crystallographica Section D-Biological Crystallography, 56, pp. 1437-1439.

Sakhamuru, K., Hough, D. W. and Chaudhuri, J. B., 2000. Protein purification by ultrafiltration using a beta-galactosidase fusion tag. Biotechnology Progress, 16 Mar-Apr (2), pp. 296-298.

Arnott, M. A., Michael, R. A., Thompson, C. R., Hough, D. W. and Danson, M. J., 2000. Thermostability and thermoactivity of citrate synthases from the thermophilic and hyperthermophilic archaea, Thermoplasma acidophilum and Pyrococcus furiosus. Journal of Molecular Biology, 304 (4), pp. 657-668.

Russell, R. J. M., Gerike, U., Danson, M. J., Hough, D. W. and Taylor, G. L., 1998. Structural adaptations of the cold-active citrate synthase from an Antarctic bacterium. Structure, 6 (3), pp. 351-361.

Gerike, U., Danson, M. J., Russell, N. J. and Hough, D. W., 1997. Sequencing and expression of the gene encoding a cold-active citrate synthase from an antarctic bacterium, strain DS2-3R. European Journal of Biochemistry, 248 (1), pp. 49-57.

Whyte, J., Hough, D., Maddison, P. J. and McHugh, N. J., 1994. The association of primary biliary cirrhosis and systemic sclerosis is not accounted for by cross reactivity between mitochondrial and centromere antigens. Journal of Autoimmunity, 7 (3), pp. 413-424.