Items by Mills, Stephen

2012

Mills, S. J., Persson, C., Cozier, G., Thomas, M. P., Trésaugues, L., Erneux, C., Riley, A. M., Nordlund, P. and Potter, B. V. L., 2012. A synthetic polyphosphoinositide headgroup surrogate in complex with SHIP2 provides a rationale for drug discovery. ACS Chemical Biology, 7 (5), pp. 822-828.

2008

Mills, S. J., Vandeput, F., Trusselle, M. N., Safrany, S. T., Erneux, C. and Potter, B. V. L., 2008. Benzene polyphosphates as tools for cell signalling: inhibition of inositol 1,4,5‐trisphosphate 5‐phosphatase and interaction with the PH domain of protein kinase Bα. ChemBiochem, 9 (11), pp. 1757-1766.

2007

Vandeput, F., Combettes, L., Mills, S. J., Backers, K., Wohlkönig, A., Parys, J. B., De Smedt, H., Missiaen, L., Dupont, G., Potter, B. V. L. and Erneux, C., 2007. Biphenyl 2,3',4,5',6-pentakisphosphate, a novel inositol polyphosphate surrogate, modulates Ca 2+ responses in rat hepatocytes. FASEB Journal, 21 (7), pp. 1481-1491.

Mills, S. J., Komander, D., Trusselle, M. N., Safrany, S. T., van Aalten, D. M. F. and Potter, B. V. L., 2007. Novel inositol phospholipid headgroup surrogate crystallized in the pleckstrin homology domain of protein kinase Bα. ACS Chemical Biology, 2 (4), pp. 242-246.

2006

Mills, S. J., Dozol, H., Vandeput, F., Backers, K., Woodman, T., Erneux, C., Spiess, B. and Potter, B. V. L., 2006. 3-hydroxybenzene 1,2,4-trisphosphate, a novel second messenger mimic and unusual substrate for type-I myo-inositol 1,4,5-trisphosphate 5-phosphatase : synthesis and physicochemistry. ChemBiochem, 7 (11), pp. 1696-1706.

2005

Poinas, A., Backers, K., Riley, A. M., Mills, S. J., Moreau, C., Potter, B. V. L. and Erneux, C., 2005. Interaction of the catalytic domain of inositol 1,4,5-trisphosphate 3-kinase A with inositol phosphate analogues. ChemBiochem, 6, pp. 1449-1457.

Poinas, A., Backers, K., Riley, A. M., Mills, S. J., Moreau, C., Potter, B. V. L. and Erneux, C., 2005. Interaction of the catalytic domain of inositol 1,4,5-trisphosphate 3-kinase A with inositol phosphate analogues. ChemBiochem, 6 (8), pp. 1449-1457.

2004

Kunerth, S., Langhorst, M. F., Schwarzmann, N., Gu, X., Huang, L., Yang, Z., Zhang, L., Mills, S. J., Zhang, L.-h., Potter, B. V. L. and Guse, A. H., 2004. Amplification and propagation of pacemaker Ca 2+ signals by cyclic ADP-ribose and the type 3 ryanodine receptor in T cells. Journal of Cell Science, 117, pp. 2141-2149.

Horne, G., Mills, S. J. and Potter, B. V. L., 2004. First derivatives of myo-inositol 1,4,6-trisphosphate modified at positions 2 and 3 : structural an analogues of D- myo -inositol 1,4,5-trisphosphate. Carbohydrate Research, 339, pp. 51-65.

2003

Mills, S. J., Riley, A. M., Liu, C., Mahon, M. F. and Potter, B. V. L., 2003. A definitive synthesis of D-myo-inositol 1,4,5,6-tetrakisphosphate and its enantiomer D-myo-inositol 3,4,5,6-tetrakisphosphate from a novel butane-2,3-diacetal-protected inositol. Chemistry - A European Journal, 9 (24), pp. 6207-6214.

Mills, S. J., Backers, K., Erneux, C. and Potter, B. V. L., 2003. Synthesis of D- and L-myo-inisitol 1,2,4,6-tetrakisphosphate regioisomers of myo -inisitol 1,3,4,5 tetrakisphosphate : activity against Ins(1,4,5)P3 binding proteins. Organic & Biomolecular Chemistry, 2003 (1), pp. 3546-3556.

Mills, S. J. and Potter, B. V. L., 2003. Synthesis of potent Ins(1,4,5)P3 5-phosphatase inhibitors by modification of myo -inositol 1,3,4,6-tetrakisphosphate. Bioorganic and Medicinal Chemistry, 11 (19), pp. 4245-4253.

2002

Mills, S. J., Liu, C. and Potter, B. V. L., 2002. Synthesis of D-and L-myo -inositol 2,4,5-trisphosphate and trisphosphorothioate : structural analogues of D-myo-inositol 1,4,5-trisphosphate. Carbohydrate Research, 337 (20), pp. 1795-1801.

2001

Ukhanov, K., Mills, S. J., Potter, B. V. L. and Walz, B., 2001. InsP3 -induced Ca2+ release in permeabilized invertebrate photoreceptors : a link between phototransduction and Ca2+ stores. Cell Calcium, 29 (5), pp. 335-345.

1999

Hirst, P. H., Riley, A. M., Mills, S. J., Spiers, I. D., Poyner, D. R., Freeman, S., Potter, B. V. L. and Smith, A. W., 1999. Inositol polyphosphate-mediated iron transport in Pseudomonas aeruginosa. Journal of Applied Microbiology, 86 (3), pp. 537-543.

1997

Hirata, M., Takeuchi, H., Riley, A. M., Mills, S. J., Watanabe, Y. and Potter, B. V. L., 1997. Inositol 1,4,5-trisphosphate receptor subtypes differentially recognize regioisomers of D-myo-inositol 1,4,5-trisphosphate. Biochemical Journal, 328 (1), pp. 93-98.

1996

Mills, S. J. and Potter, B. V. L., 1996. Synthesis of D- and L- myo-inositol 1,4,6-trisphosphate, regioisomers of a ubiquitous second messenger. Journal of Organic Chemistry, 61 (25), pp. 8980-8987.

1995

Ward, S. G., Mills, S. J., Liu, C., Westwick, J. and Potter, B. V. L., 1995. D-myo-inositol 1,4,5-trisphosphate analogues modified at the 3-position inhibit phosphatidylinositol 3-kinase. Journal of Biological Chemistry, 270 (20), pp. 12075-12084.

Mills, S. J., Riley, A. M., Murphy, C. T., Bullock, A. J., Westwick, J. and Potter, B. V. L., 1995. Myo-inositol 1,4,6-trisphosphorothioate and myo-inositol 1,3,4-trisphosphorothioate: new synthetic Ca2+-mobilising partial agonists at the inositol 1,4,5-trisphosphate receptor. Bioorganic & Medicinal Chemistry Letters, 5 (3), pp. 203-208.

1994

Safrany, S. T., Mills, S. J., Liu, C., Lampe, D., Noble, N. J., Nahorski, S. R. and Potter, B. V. L., 1994. Design of potent and selective inhibitors of myo-Inositol 1,4,5-trisphosphate 5-phosphatase. Biochemistry, 33 (35), pp. 10763-10769.

Wilcox, R. A., Safrany, S. T., Lampe, D., Mills, S. J., Nahorski, S. R. and Potter, B. V. L., 1994. Modification at C2 of myo-inositol 1,4,5-trisphosphate produces inositol trisphosphates and tetrakisphosphates with potent biological activities. European Journal of Biochemistry, 223 (1), pp. 115-124.

1993

Mills, S. J., Al-hafidh, J., Westwick, J. and Potter, B. V.L., 1993. Myo-inositol 1,4,6-trisphosphate: A new synthetic Ca2+-mobilising inositol phosphate. Bioorganic & Medicinal Chemistry Letters, 3 (12), pp. 2599-2604.

Mills, S. J., Safrany, S. T., Wilcox, R. A., Nahorski, S. R. and Potter, B. V. L., 1993. Synthesis of myo-inositol 1,2,4,5-tetrakisphosphate, a Ca2+-mobilising tetrakisphosphate with a potency similar to myo-inositol 1,4,5-trisphosphate. Bioorganic & Medicinal Chemistry Letters, 3 (8), pp. 1505-1510.

1992

Lampe, D., Mills, S. J. and Potter, B. V. L., 1992. Total synthesis of the second messenger analogue D-myo-inositol 1-phosphorothioate 4,5-bisphosphate: optical resolution of DL-1-O-allyl-2,3,6-tri-O-benzyl-myo-inositol and fluorescent labelling of myo-inositol 1,4,5-trisphosphate. Journal of the Chemical Society - Perkin Transcriptions 1, 1992 (21), pp. 2899-2906.