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Items by Thomas, Mark

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Number of items: 21.

Leese, M. P., Jourdan, F. L., Major, M. R., Dohle, W., Thomas, M. P., Hamel, E., Ferrandis, E., Mahon, M. F., Newman, S. P., Purohit, A. and Potter, B. V. L., 2014. Synthesis, anti-tubulin and antiproliferative SAR of steroidomimetic dihydroisoquinolinones. ChemMedChem, 9 (4), pp. 798-812.

Swarbrick, J. M., Graeff, R., Garnham, C., Thomas, M. P., Galione, A. and Potter, B. V. L., 2014. 'Click cyclic ADP-ribose' : A neutral second messenger mimic. Chemical Communications, 50 (19), pp. 2458-2461.

Thomas, M. P. and Potter, B. V. L., 2014. The enzymes of human diphosphoinositol polyphosphate metabolism. FEBS Journal, 281 (1), pp. 14-33.

Moreau, C., Liu, Q., Graeff, R., Wagner, G.K., Thomas, M.P., Swarbrick, J.M., Shuto, S., Lee, H.C., Hao, Q. and Potter, B.V.L., 2013. CD38 Structure-Based Inhibitor Design Using the N1-Cyclic Inosine 5′-Diphosphate Ribose Template. PLoS ONE, 8 (6), e66247.

Woo, L.W.L., Wood, P.M., Bubert, C., Thomas, M.P., Purohit, A. and Potter, B.V.L., 2013. Synthesis and structure-activity relationship studies of derivatives of the dual aromatase-sulfatase inhibitor 4-{[(4-Cyanophenyl)(4H-1,2,4-triazol-4-yl)amino]methyl}phenyl sulfamate. ChemMedChem, 8 (5), pp. 779-799.

Godage, H. Y., Riley, A. M., Woodman, T. J., Thomas, M. P., Mahon, M. F. and Potter, B. V. L., 2013. Regioselective opening of myo-inositol orthoesters : Mechanism and synthetic utility. Journal of Organic Chemistry, 78 (6), pp. 2275-2288.

Greedy, B. M., Bradbury, F., Thomas, M. P., Grivas, K., Cami-Kobeci, G., Archambeau, A., Bosse, K., Clark, M. J., Aceto, M., Lewis, J. W., Traynor, J. R. and Husbands, S. M., 2013. Orvinols with mixed kappa/mu opioid receptor agonist activity. Journal of Medicinal Chemistry, 56 (8), pp. 3207-3216.

Thomas, M. P. and Potter, B. V. L., 2013. The structural biology of oestrogen metabolism. Journal of Steroid Biochemistry and Molecular Biology, 137, pp. 27-49.

Su, X., Halem, H. A., Thomas, M. P., Moutrille, C., Culler, M. D., Vicker, N. and Potter, B. V. L., 2012. Adamantyl carboxamides and acetamides as potent human 11β- hydroxysteroid dehydrogenase type 1 inhibitors. Bioorganic and Medicinal Chemistry, 20 (21), pp. 6394-6402.

Pradaux-Caggiano, F., Su, X., Vicker, N., Thomas, M. P., Smithen, D., Halem, H. A., Culler, M. D. and Potter, B. V. L., 2012. Synthesis and evaluation of thiadiazole derivatives as inhibitors of 11β-hydroxysteroid dehydrogenase type 1. MedChemComm, 3 (9), pp. 1117-1124.

Mills, S. J., Persson, C., Cozier, G., Thomas, M. P., Trésaugues, L., Erneux, C., Riley, A. M., Nordlund, P. and Potter, B. V. L., 2012. A synthetic polyphosphoinositide headgroup surrogate in complex with SHIP2 provides a rationale for drug discovery. ACS Chemical Biology, 7 (5), pp. 822-828.

Moreau, C., Kirchberger, T., Zhang, B., Thomas, M. P., Weber, K., Guse, A. H. and Potter, B. V. L., 2012. Aberrant cyclization affords a C-6 modified cyclic adenosine 5′-diphosphoribose analogue with biological activity in Jurkat T cells. Journal of Medicinal Chemistry, 55 (4), pp. 1478-1489.

Sureshan, K. M., Riley, A. M., Thomas, M. P., Tovey, S. C., Taylor, C. W. and Potter, B. V. L., 2012. Contribution of phosphates and adenine to the potency of adenophostins at the IP 3 receptor : synthesis of all possible bisphosphates of adenophostin A. Journal of Medicinal Chemistry, 55 (4), pp. 1706-1720.

Leese, M. P., Jourdan, F., Dohle, W., Kimberley, M. R., Thomas, M. P., Bai, R., Hamel, E., Ferrandis, E. and Potter, B. V. L., 2012. Steroidomimetic tetrahydroisoquinolines for the design of new microtubule disruptors. ACS Medicinal Chemistry Letters, 3 (1), pp. 5-9.

Woo, L. W. L., Ganeshapillai, D., Thomas, M. P., Sutcliffe, O. B., Malini, B., Mahon, M. F., Purohit, A. and Potter, B. V. L., 2011. Structure-activity relationship for the first-in-class clinical steroid sulfatase inhibitor irosustat (STX64, BN83495). ChemMedChem, 6 (11), pp. 2019-2034.

Su, X., Pradaux-Caggiano, F., Vicker, N., Thomas, M. P., Halem, H., Culler, M. D. and Potter, B. V. L., 2011. Adamantyl ethanone pyridyl derivatives : potent and selective inhibitors of human 11 beta-hydroxysteroid dehydrogenase type 1. ChemMedChem, 6 (9), pp. 1616-1629.

Wood, P. M., Woo, L. W. L., Thomas, M. P., Mahon, M. F., Purohit, A. and Potter, B. V. L., 2011. Aromatase and dual aromatase-steroid sulfatase inhibitors from the letrozole and vorozole templates. ChemMedChem, 6 (8), pp. 1423-1438.

Su, X., Vicker, N., Thomas, M. P., Pradaux-Caggiano, F., Halem, H., Culler, M. D. and Potter, B. V. L., 2011. Discovery of adamantyl heterocyclic ketones as potent 11 beta-hydroxysteroid dehydrogenase type 1 inhibitors. ChemMedChem, 6 (8), pp. 1439-1451.

Thomas, M. P. and Potter, B. V. L., 2011. Crystal structures of II beta-hydroxysteroid dehydrogenase type I and their use in drug discovery. Future Medicinal Chemistry, 3 (3), pp. 367-390.

Wood, P. M., Woo, L. W. L., Labrosse, J.-R., Thomas, M. P., Mahon, M. F., Chander, S. K., Purohit, A., Reed, M. J. and Potter, B. V. L., 2010. Bicyclic derivatives of the potent dual aromatase-steroid sulfatase inhibitor 2-bromo-4-{ (4-cyanophenyl)(4H-1,2,4-triazol-4-yl)amino methyl}phenylsul famate : synthesis, SAR, crystal structure, and in vitro and in vivo activities. ChemMedChem, 5 (9), pp. 1577-1593.

Su, X., Pradaux-Caggiano, F., Thomas, M. P., Szeto, M. W. Y., Halem, H. A., Culler, M. D., Vicker, N. and Potter, B. V. L., 2010. Discovery of adamantyl ethanone derivatives as potent 11β-hydroxysteroid dehydrogenase Type 1 (11β-HSD1) inhibitors. ChemMedChem, 5 (7), pp. 1026-1044.

This list was generated on Thu Oct 23 01:43:37 2014 IST.