Items by Thomas, Mark

Articles

Greedy, B. M., Bradbury, F. A., Thomas, M. P., Grivas, K., Cami-Kobeci, G., Archambeau, M., Lewis, J. W., Traynor, J. R. and Husbands, S. M., 2013. Orvinols with mixed kappa/mu opioid receptor agonist activity. Journal of Medicinal Chemistry, 56 (8), pp. 3207-3216.

Godage, H. Y., Riley, A. M., Woodman, T. J., Thomas, M. P., Mahon, M. F. and Potter, B. V. L., 2013. Regioselective opening of myo-inositol orthoesters: mechanism and synthetic utility. Journal of Organic Chemistry, 78 (6), pp. 2275-2288.

Thomas, M.P. and Potter, B.V.L., 2013. Forthcoming. The structural biology of oestrogen metabolism. Journal of Steroid Biochemistry and Molecular Biology

Su, X., Halem, H.A., Thomas, M.P., Moutrille, C., Culler, M.D., Vicker, N. and Potter, B.V.L., 2012. Adamantyl carboxamides and acetamides as potent human 11β- hydroxysteroid dehydrogenase type 1 inhibitors. Bioorganic and Medicinal Chemistry, 20 (21), pp. 6394-6402.

Pradaux-Caggiano, F., Su, X., Vicker, N., Thomas, M.P., Smithen, D., Halem, H.A., Culler, M.D. and Potter, B.V.L., 2012. Synthesis and evaluation of thiadiazole derivatives as inhibitors of 11β-hydroxysteroid dehydrogenase type 1. MedChemComm, 3 (9), pp. 1117-1124.

Mills, S. J., Persson, C., Cozier, G., Thomas, M. P., Trésaugues, L., Erneux, C., Riley, A. M., Nordlund, P. and Potter, B. V. L., 2012. A synthetic polyphosphoinositide headgroup surrogate in complex with SHIP2 provides a rationale for drug discovery. ACS Chemical Biology, 7 (5), pp. 822-828.

Moreau, C., Kirchberger, T., Zhang, B., Thomas, M. P., Weber, K., Guse, A. H. and Potter, B. V. L., 2012. Aberrant cyclization affords a C-6 modified cyclic adenosine 5′-diphosphoribose analogue with biological activity in Jurkat T cells. Journal of Medicinal Chemistry, 55 (4), pp. 1478-1489.

Sureshan, K. M., Riley, A. M., Thomas, M. P., Tovey, S. C., Taylor, C. W. and Potter, B. V. L., 2012. Contribution of phosphates and adenine to the potency of adenophostins at the IP 3 receptor: Synthesis of all possible bisphosphates of adenophostin A. Journal of Medicinal Chemistry, 55 (4), pp. 1706-1720.

Leese, M. P., Jourdan, F., Dohle, W., Kimberley, M. R., Thomas, M. P., Bai, R. L., Hamel, E., Ferrandis, E. and Potter, B. V. L., 2012. Steroidomimetic tetrahydroisoquinolines for the design of new microtubule disruptors. ACS Medicinal Chemistry Letters, 3 (1), pp. 5-9.

Su, X. D., Pradaux-Caggiano, F., Vicker, N., Thomas, M. P., Halem, H., Culler, M. D. and Potter, B. V. L., 2011. Adamantyl ethanone pyridyl derivatives: potent and selective inhibitors of human 11 beta-hydroxysteroid dehydrogenase type 1. ChemMedChem, 6 (9), pp. 1616-1629.

Wood, P. M., Woo, L. W. L., Thomas, M. P., Mahon, M. F., Purohit, A. and Potter, B. V. L., 2011. Aromatase and dual aromatase-steroid sulfatase inhibitors from the letrozole and vorozole templates. ChemMedChem, 6 (8), pp. 1423-1438.

Su, X. D., Vicker, N., Thomas, M. P., Pradaux-Caggiano, F., Halem, H., Culler, M. D. and Potter, B. V. L., 2011. Discovery of Adamantyl Heterocyclic Ketones as Potent 11 beta-Hydroxysteroid Dehydrogenase Type 1 Inhibitors. ChemMedChem, 6 (8), pp. 1439-1451.

Thomas, M. P. and Potter, B. V. L., 2011. Crystal structures of II beta-hydroxysteroid dehydrogenase type I and their use in drug discovery. Future Medicinal Chemistry, 3 (3), pp. 367-390.

Woo, L. W. L., Ganeshapillai, D., Thomas, M. P., Sutcliffe, O. B., Malini, B., Mahon, M. F., Purohit, A. and Potter, B. V. L., 2011. Structure-activity relationship for the first-in-class clinical steroid sulfatase inhibitor irosustat (STX64, BN83495). ChemMedChem, 6 (11), pp. 2019-2034.

Wood, P., Woo, L., Labrosse, J. R., Thomas, M. P., Mahon, M. F., Chander, S. K., Purohit, A., Reed, M. J. and Potter, B. V. L., 2010. Bicyclic Derivatives of the Potent Dual Aromatase-Steroid Sulfatase Inhibitor 2-Bromo-4-{ (4-cyanophenyl)(4H-1,2,4-triazol-4-yl)amino methyl}phenylsul famate: Synthesis, SAR, Crystal Structure, and in vitro and in vivo Activities. ChemMedChem, 5 (9), pp. 1577-1593.

Su, X., Pradaux-Caggiano, F., Thomas, M. P., Szeto, M. W. Y., Halem, H. A., Culler, M. D., Vicker, N. and Potter, B. V. L., 2010. Discovery of adamantyl ethanone derivatives as potent 11β-hydroxysteroid dehydrogenase Type 1 (11β-HSD1) inhibitors. ChemMedChem, 5 (7), pp. 1026-1044.