Items by Williams, Dr Robert J

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Number of items: 63.


Williams, R. J., Mohanakumar, K. and Beart, P. M., 2015. Neuro-nutraceuticals:the path to brain health via nourishment is not so distant. Neurochemistry International, 89, pp. 1-6. Item availability may be restricted.

Cox, C. J., Choudhry, F., Peacey, E., Perkinton, M. S., Richardson, J. C., Howlett, D. R., Lichtenthaler, S. F., Francis, P. T. and Williams, R. J., 2015. Dietary (-)-epicatechin as a potent inhibitor of βγ-secretase amyloid precursor protein processing. Neurobiology of Aging, 36 (1), pp. 178-187.


Tan, M. G. K., Lee, C., Lee, J. H., Francis, P. T., Williams, R. J., Ramírez, M. J., Chen, C. P., Wong, P. T.-H. and Lai, M. K. P., 2014. Decreased rabphilin 3A immunoreactivity in Alzheimer's disease is associated with Aβ burden. Neurochemistry International, 64, pp. 29-36.


Vazour, D., Rattray, M., Williams, R. J. and Spencer, J., 2013. Potential neuroprotective actions of dietary flavonoids. In: Ramawat, K. G. and Merillion, J.-M., eds. Handbook of Natural Products. Springer, pp. 2617-2640.


Guadagna, S., Esiri, M. M., Williams, R. J. and Francis, P. T., 2012. Tau phosphorylation in human brain: relationship to behavioral disturbance in dementia. Neurobiology of Aging, 33 (12), pp. 2798-2806.

Bahia, P. K., Pugh, V., Hoyland, K., Hensley, V., Rattray, M. and Williams, R. J., 2012. Neuroprotective effects of phenolic antioxidant tBHQ associate with inhibition of FoxO3a nuclear translocation and activity. Journal of Neurochemistry, 123 (1), pp. 182-191.

McHugh, P. C., Wright, J. A., Williams, R. J. and Brown, D. R., 2012. Prion protein expression alters APP cleavage without interaction with BACE-1. Neurochemistry International, 61 (5), pp. 672-680.

Choudhry, F., Howlett, D. R., Richardson, J. C., Francis, P. T. and Williams, R. J., 2012. Pro-oxidant diet enhances β/γ secretase-mediated APP processing in APP/PS1 transgenic mice. Neurobiology of Aging, 33 (5), pp. 960-968.

Spencer, J. P. E., Vafeiadou, K., Williams, R. J. and Vauzour, D., 2012. Neuroinflammation: Modulation by flavonoids and mechanisms of action. Molecular Aspects of Medicine, 33 (1), pp. 83-97.


Gaeta, A., Molina-Holgado, F., Kong, X. L., Salvage, S., Fakih, S., Francis, P. T., Williams, R. J. and Hider, R. C., 2011. Synthesis, physical-chemical characterisation and biological evaluation of novel 2-amido-3-hydroxypyridin-4(1H)-ones: Iron chelators with the potential for treating Alzheimer's disease. Bioorganic & Medicinal Chemistry, 19 (3), pp. 1285-97.


Thambisetty, M., Simmons, A., Velayudhan, L., Hye, A., Campbell, J., Zhang, Y., Wahlund, L.-O., Westman, E., Guntert, A., Kinsey, A., Proitsi, P., Powell, J., Causevic, M., Killick, R., Lunnon, K., Lynham, S., Broadstock, M., Choudhry, F., Howlett, D., Williams, R., Sharp, S., Mitchlemore, C., Tunnard, C., Leung, R., Foy, C., O'Brien, D., Breen, G., Furney, S., Ward, M., Kloszewska, I., Mecocco, P., Soininen, H., Tsolaki, M., Vellas, B., Hodges, A., Murphy, D., Parkins, S., Richardson, J., Resnik, S., Ferrucci, L., Wong, D., Zhou, Y., Muehlboeck, S., Evans, A., Francis, P., Spenger, C. and Lovestone, S., 2010. Association of plasma clusterin concentration with severity, pathology, and progression in Alzheimer disease. Archives of General Psychiatry, 67 (7), pp. 739-748.


Hoey, S. E., Williams, R. J. and Perkinton, M. S., 2009. Synaptic NMDA receptor activation stimulates α-secretase amyloid precursor protein processing and inhibits amyloid-β production. The Journal of Neuroscience: The Official Journal of the Society for Neuroscience, 29 (14), pp. 4442-4460.

Vafeiadou, K., Vauzour, D., Lee, H. Y., Rodriguez-Mateos, A., Williams, R. J. and Spencer, J. P. E., 2009. The citrus flavanone naringenin inhibits inflammatory signalling in glial cells and protects against neuroinflammatory injury. Archives of Biochemistry and Biophysics, 484 (1), pp. 100-109.


Vafeiadou, K., Vauzour, D., Rodriguez-Mateos, A., Whiteman, M., Williams, R. and Spencer, J., 2008. Glial metabolism of quercetin reduces its neurotoxic potential. Archives of Biochemistry and Biophysics, 478 (2), pp. 195-200.

Abbott, J. J., Howlett, D. R., Francis, P. T. and Williams, R. J., 2008. Aβ1-42 modulation of Akt phosphorylation via α7 nAChR and NMDA receptors. Neurobiology of Aging, 29 (7), pp. 992-1001.

Rainey-Smith, S., Schroetke, L.-W., Bahia, P., Fahmi, A., Skilton, R., Spencer, J. P. E., Rice-Evans, C., Rattray, M. and Williams, R. J., 2008. Neuroprotective effects of hesperetin in mouse primary neurones are independent of CREB activation. Neuroscience Letters, 438 (1), pp. 29-33.

Pezet, S., Marchand, F., D'Mello, R., Grist, J., Clark, A. K., Malcangio, M., Dickenson, A. H., Williams, R. J. and McMahon, S. B., 2008. Phosphatidylinositol 3-kinase is a key mediator of central sensitization in painful inflammatory conditions. The Journal of Neuroscience: The Official Journal of the Society for Neuroscience, 28 (16), pp. 4261-4270.

Molina-Holgado, F., Gaeta, A., Francis, P. T., Williams, R. J. and Hider, R. C., 2008. Neuroprotective actions of deferiprone in cultured cortical neurones and SHSY-5Y cells. Journal of Neurochemistry, 105 (6), pp. 2466-2476.


Schroeter, H., Bahia, P., Spencer, J. P. E., Sheppard, O., Rattray, M., Cadenas, E., Rice-Evans, C. and Williams, R. J., 2007. (-)Epicatechin stimulates ERK-dependent cyclic AMP response element activity and up-regulates GluR2 in cortical neurons. Journal of Neurochemistry, 101 (6), pp. 1596-1606.

Vauzour, D., Vafeiadou, K., Rice-Evans, C., Williams, R. J. and Spencer, J. P. E., 2007. Activation of pro-survival Akt and ERK1/2 signalling pathways underlie the anti-apoptotic effects of flavanones in cortical neurons. Journal of Neurochemistry, 103 (4), pp. 1355-67.

Molina-Holgado, F., Rubio-Araiz, A., García-Ovejero, D., Williams, R. J., Moore, J. D., Arévalo-Martín, A., Gómez-Torres, O. and Molina-Holgado, E., 2007. CB2 cannabinoid receptors promote mouse neural stem cell proliferation. European Journal of Neuroscience, 25 (3), pp. 629-34.

Molina-Holgado, F., Hider, R. C., Gaeta, A., Williams, R. and Francis, P., 2007. Metals ions and neurodegeneration. Biometals, 20 (3-4), pp. 639-54.



Pezet, S., Spyropoulos, A., Williams, R. J. and McMahon, S. B., 2005. Activity-dependent phosphorylation of Akt/PKB in adult DRG neurons. European Journal of Neuroscience, 21 (7), pp. 1785-97.


Williams, R. J., Spencer, J. P. E. and Rice-Evans, C., 2004. Flavonoids: antioxidants or signalling molecules? Free Radical Biology and Medicine, 36 (7), pp. 838-849.

Tortarolo, M., Crossthwaite, A. J., Conforti, L., Spencer, J. P., Williams, R. J., Bendotti, C. and Rattray, M., 2004. Expression of SOD1 G93A or wild-type SOD1 in primary cultures of astrocytes down-regulates the glutamate transporter GLT-1 : lack of involvement of oxidative stress. Journal of Neurochemistry, 88 (2), pp. 481-93.

Williams, R. J., Spencer, J. P. E., Goni, F. M. and Rice-Evans, C. A., 2004. Zinc-histidine complex protects cultured cortical neurons against oxidative stress-induced damage. Neuroscience Letters, 371 (2-3), pp. 106-10.


Spencer, J. P. E., Kuhnle, G. G. C., Williams, R. J. and Rice-Evans, C., 2003. Intracellular metabolism and bioactivity of quercetin and its in vivo metabolites. Biochemical Journal, 372 (1), pp. 173-81.

Suchak, S. K., Baloyianni, N. V., Perkinton, M. S., Williams, R. J., Meldrum, B. S. and Rattray, M., 2003. The 'glial' glutamate transporter, EAAT2 (Glt-1) accounts for high affinity glutamate uptake into adult rodent nerve endings. Journal of Neurochemistry, 84 (3), pp. 522-32.


Schroeter, H., Boyd, C., Spencer, J. P. E., Williams, R. J., Cadenas, E. and Rice-Evans, C., 2002. MAPK signaling in neurodegeneration : influences of flavonoids and of nitric oxide. Neurobiology of Aging, 23 (5), pp. 861-80.

Pezet, S., Malcangio, M., Lever, I. J., Perkinton, M. S., Thompson, S. W. N., Williams, R. J. and McMahon, S. B., 2002. Noxious stimulation induces Trk receptor and downstream ERK phosphorylation in spinal dorsal horn. Molecular and Cellular Neuroscience, 21 (4), pp. 684-95.

Perkinton, M. S., Ip, J. K., Wood, G. L., Crossthwaite, A. J. and Williams, R. J., 2002. Phosphatidylinositol 3-kinase is a central mediator of NMDA receptor signalling to MAP kinase (Erk1/2), Akt/PKB and CREB in striatal neurones. Journal of Neurochemistry, 80 (2), pp. 239-54.


Spencer, J. P., Schroeter, H., Crossthwaithe, A. J., Kuhnle, G., Williams, R. J. and Rice-Evans, C., 2001. Contrasting influences of glucuronidation and O-methylation of epicatechin on hydrogen peroxide-induced cell death in neurons and fibroblasts. Free Radical Biology and Medicine, 31 (9), pp. 1139-46.


Schroeter, H., Williams, R. J., Matin, R., Iversen, L. and Rice-Evans, C. A., 2000. Phenolic antioxidants attenuate neuronal cell death following uptake of oxidized low-density lipoprotein. Free Radical Biology and Medicine, 29 (12), pp. 1222-33.



Molloy, G. Y., Rattray, M. and Williams, R. J., 1998. Genes encoding multiple forms of phospholipase A2 are expressed in rat brain. Neuroscience Letters, 258 (3), pp. 139-142.

Samanta, S., Perkinton, M. S., Morgan, M. and Williams, R. J., 1998. Hydrogen peroxide enhances signal-responsive arachidonic acid release from neurons : role of mitogen-activated protein kinase. Journal of Neurochemistry, 70 (5), pp. 2082-2090.

Akbar, M. T., Rattray, M., Williams, R. J., Chong, N. W. and Meldrum, B. S., 1998. Reduction of GABA and glutamate transporter messenger RNAs in the severe-seizure genetically epilepsy-prone rat. Neuroscience, 85 (4), pp. 1235-1251.


Navamani, M., Morgan, M. and Williams, R. J., 1997. Ethanol modulates N-methyl-D-aspartate-evoked arachidonic acid release from neurones. European Journal of Pharmacology, 340 (1), pp. 27-34.


Williams, R. J. and Glowinski, J., 1996. Cyclothiazide unmasks an AMPA-evoked release of arachidonic acid from cultured striatal neurones. Journal of Neurochemistry, 67 (4), pp. 1551-1558.

Williams, R. J., Maus, M., Stella, N., Glowinski, J. and Premont, J., 1996. Reduced glucose metabolism enhances the glutamate-evoked release of arachidonic acid from striatal neurons. Neuroscience, 74 (2), pp. 461-468.


Williams, R. J., Murphy, N., Glowinski, J. and Prémont, J., 1995. Glucose regulates glutamate-evoked arachidonic acid release from cultured striatal neurons. Journal of Neurochemistry, 65 (1), pp. 241-249.

Williams, R. J. and Kelly, E., 1995. Measurement of adenylyl cyclase activity in cell membranes. In: Kendall, D. A. and Hill, S. J., eds. Signal Transduction Protocols. Totowa, USA: Humana Press, pp. 63-77. (Methods in Molecular Biology; 41)



Williams, R. J. and Kelly, E., 1993. Chronic Ethanol Reduces Immunologically Detectable Gqα/11α in NG108–15 Cells. Journal of Neurochemistry, 61 (3), pp. 1163-1166.

Williams, R. J., Veale, M. A. and Kelly, E., 1993. Involvement of adenosine in ethanol-induced changes in G-protein expression in NG108-15 cells? Alcohol and Alcoholism: Supplement, 2, pp. 431-435.


Bramley, T. A., Menzies, G. S., Williams, R. J., Kinsman, O. S. and Adams, D. J., 1991. Binding sites for LH in Candida albicans : comparison with the mammalian corpus luteum LH receptor. Journal of Endocrinology, 130 (2), pp. 177-190.


Williams, R. J., Dickinson, K., Kinsman, O. S., Bramley, T. A., Menzies, G. S. and Adams, D. J., 1990. Receptor-mediated elevation of adenylate cyclase by luteinizing hormone in Candida albicans. Journal of General Microbiology, 136 (11), pp. 2143-2148.

Bramley, T. A., Menzies, G. S., Williams, R. J., Kinsman, O. S. and Adams, D. J., 1990. Specific, high-affinity binding sites for human luteinizing hormone (hLH) and human chorionic gonadotrophin (hCG) in Candida species. Biochemical and Biophysical Research Communications, 167 (3), pp. 1050-1056.

This list was generated on Wed Nov 25 00:02:24 2015 GMT.