Items by Williams, Dr Robert J

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Number of items: 68.


Carvalho, D., Paulino, M., Polticelli, F., Arredondo, F., Williams, R. J. and Abin-Carriquiry, J. A., 2017. Structural evidence of quercetin multi-target bioactivity:A reverse virtual screening strategy. European Journal of Pharmaceutical Sciences, 106, pp. 393-403. Item availability may be restricted.

Vauzour, D., Camprubi-Robles,, M., Miquel-Kergoat, S., Andres-Lacueva, C., Banati, D., Barberger-Gateau, P., Bowman, G., Carbelotto, L., Clarke, R., Hogervorst, E., Kiliaan, A., Lucca, U., Manach, C., Minihane, A.-M., Mitchell, E. S., Perneczky, R., Perry, H., Roussel, A.-M., Schuermans, J., Sijben, J., Spencer, J. P., Thuret, S., van de Rest, O., Vandewoude, M., Wesnes, K., Williams, R. J., Williams, R. S. and Ramirez, M., 2017. Nutrition for the ageing brain: towards evidence for an optimal diet. Ageing Research Reviews, 35, pp. 222-240.


Williams, R. J., Mohanakumar, K. P. and Beart, P. M., 2016. Neuro-nutraceuticals: Further insights into their promise for brain health. Neurochemistry International, 95, pp. 1-3.


Williams, R. J., Mohanakumar, K. and Beart, P. M., 2015. Neuro-nutraceuticals:the path to brain health via nourishment is not so distant. Neurochemistry International, 89, pp. 1-6.

Cox, C. J., Choudhry, F., Peacey, E., Perkinton, M. S., Richardson, J. C., Howlett, D. R., Lichtenthaler, S. F., Francis, P. T. and Williams, R. J., 2015. Dietary (-)-epicatechin as a potent inhibitor of βγ-secretase amyloid precursor protein processing. Neurobiology of Aging, 36 (1), pp. 178-187.


Tan, M. G. K., Lee, C., Lee, J. H., Francis, P. T., Williams, R. J., Ramírez, M. J., Chen, C. P., Wong, P. T.-H. and Lai, M. K. P., 2014. Decreased rabphilin 3A immunoreactivity in Alzheimer's disease is associated with Aβ burden. Neurochemistry International, 64, pp. 29-36.


Vazour, D., Rattray, M., Williams, R. J. and Spencer, J., 2013. Potential neuroprotective actions of dietary flavonoids. In: Ramawat, K. G. and Merillion, J.-M., eds. Handbook of Natural Products. Springer, pp. 2617-2640.


Guadagna, S., Esiri, M. M., Williams, R. J. and Francis, P. T., 2012. Tau phosphorylation in human brain: relationship to behavioral disturbance in dementia. Neurobiology of Aging, 33 (12), pp. 2798-2806.

Bahia, P. K., Pugh, V., Hoyland, K., Hensley, V., Rattray, M. and Williams, R. J., 2012. Neuroprotective effects of phenolic antioxidant tBHQ associate with inhibition of FoxO3a nuclear translocation and activity. Journal of Neurochemistry, 123 (1), pp. 182-191.

McHugh, P. C., Wright, J. A., Williams, R. J. and Brown, D. R., 2012. Prion protein expression alters APP cleavage without interaction with BACE-1. Neurochemistry International, 61 (5), pp. 672-680.

Choudhry, F., Howlett, D. R., Richardson, J. C., Francis, P. T. and Williams, R. J., 2012. Pro-oxidant diet enhances β/γ secretase-mediated APP processing in APP/PS1 transgenic mice. Neurobiology of Aging, 33 (5), pp. 960-968.

Spencer, J. P. E., Vafeiadou, K., Williams, R. J. and Vauzour, D., 2012. Neuroinflammation: Modulation by flavonoids and mechanisms of action. Molecular Aspects of Medicine, 33 (1), pp. 83-97.


Gaeta, A., Molina-Holgado, F., Kong, X. L., Salvage, S., Fakih, S., Francis, P. T., Williams, R. J. and Hider, R. C., 2011. Synthesis, physical-chemical characterisation and biological evaluation of novel 2-amido-3-hydroxypyridin-4(1H)-ones: Iron chelators with the potential for treating Alzheimer's disease. Bioorganic & Medicinal Chemistry, 19 (3), pp. 1285-97.


Thambisetty, M., Simmons, A., Velayudhan, L., Hye, A., Campbell, J., Zhang, Y., Wahlund, L.-O., Westman, E., Guntert, A., Kinsey, A., Proitsi, P., Powell, J., Causevic, M., Killick, R., Lunnon, K., Lynham, S., Broadstock, M., Choudhry, F., Howlett, D., Williams, R. J., Sharp, S., Mitchlemore, C., Tunnard, C., Leung, R., Foy, C., O'Brien, D., Breen, G., Furney, S., Ward, M., Kloszewska, I., Mecocco, P., Soininen, H., Tsolaki, M., Vellas, B., Hodges, A., Murphy, D., Parkins, S., Richardson, J., Resnik, S., Ferrucci, L., Wong, D., Zhou, Y., Muehlboeck, S., Evans, A., Francis, P., Spenger, C. and Lovestone, S., 2010. Association of plasma clusterin concentration with severity, pathology, and progression in Alzheimer disease. Archives of General Psychiatry, 67 (7), pp. 739-748.


Hoey, S. E., Williams, R. J. and Perkinton, M. S., 2009. Synaptic NMDA receptor activation stimulates α-secretase amyloid precursor protein processing and inhibits amyloid-β production. The Journal of Neuroscience: The Official Journal of the Society for Neuroscience, 29 (14), pp. 4442-4460.

Vafeiadou, K., Vauzour, D., Lee, H. Y., Rodriguez-Mateos, A., Williams, R. J. and Spencer, J. P. E., 2009. The citrus flavanone naringenin inhibits inflammatory signalling in glial cells and protects against neuroinflammatory injury. Archives of Biochemistry and Biophysics, 484 (1), pp. 100-109.


Vafeiadou, K., Vauzour, D., Rodriguez-Mateos, A., Whiteman, M., Williams, R. and Spencer, J., 2008. Glial metabolism of quercetin reduces its neurotoxic potential. Archives of Biochemistry and Biophysics, 478 (2), pp. 195-200.

Abbott, J. J., Howlett, D. R., Francis, P. T. and Williams, R. J., 2008. Aβ1-42 modulation of Akt phosphorylation via α7 nAChR and NMDA receptors. Neurobiology of Aging, 29 (7), pp. 992-1001.

Rainey-Smith, S., Schroetke, L.-W., Bahia, P., Fahmi, A., Skilton, R., Spencer, J. P. E., Rice-Evans, C., Rattray, M. and Williams, R. J., 2008. Neuroprotective effects of hesperetin in mouse primary neurones are independent of CREB activation. Neuroscience Letters, 438 (1), pp. 29-33.

Pezet, S., Marchand, F., D'Mello, R., Grist, J., Clark, A. K., Malcangio, M., Dickenson, A. H., Williams, R. J. and McMahon, S. B., 2008. Phosphatidylinositol 3-kinase is a key mediator of central sensitization in painful inflammatory conditions. The Journal of Neuroscience: The Official Journal of the Society for Neuroscience, 28 (16), pp. 4261-4270.

Molina-Holgado, F., Gaeta, A., Francis, P. T., Williams, R. J. and Hider, R. C., 2008. Neuroprotective actions of deferiprone in cultured cortical neurones and SHSY-5Y cells. Journal of Neurochemistry, 105 (6), pp. 2466-2476.


Schroeter, H., Bahia, P., Spencer, J. P. E., Sheppard, O., Rattray, M., Cadenas, E., Rice-Evans, C. and Williams, R. J., 2007. (-)Epicatechin stimulates ERK-dependent cyclic AMP response element activity and up-regulates GluR2 in cortical neurons. Journal of Neurochemistry, 101 (6), pp. 1596-1606.

Vauzour, D., Vafeiadou, K., Rice-Evans, C., Williams, R. J. and Spencer, J. P. E., 2007. Activation of pro-survival Akt and ERK1/2 signalling pathways underlie the anti-apoptotic effects of flavanones in cortical neurons. Journal of Neurochemistry, 103 (4), pp. 1355-67.

Molina-Holgado, F., Rubio-Araiz, A., García-Ovejero, D., Williams, R. J., Moore, J. D., Arévalo-Martín, A., Gómez-Torres, O. and Molina-Holgado, E., 2007. CB2 cannabinoid receptors promote mouse neural stem cell proliferation. European Journal of Neuroscience, 25 (3), pp. 629-34.

Molina-Holgado, F., Hider, R. C., Gaeta, A., Williams, R. and Francis, P., 2007. Metals ions and neurodegeneration. Biometals, 20 (3-4), pp. 639-54.



Pezet, S., Spyropoulos, A., Williams, R. J. and McMahon, S. B., 2005. Activity-dependent phosphorylation of Akt/PKB in adult DRG neurons. European Journal of Neuroscience, 21 (7), pp. 1785-97.


Williams, R. J., Spencer, J. P. E. and Rice-Evans, C., 2004. Flavonoids: antioxidants or signalling molecules? Free Radical Biology and Medicine, 36 (7), pp. 838-849.

Tortarolo, M., Crossthwaite, A. J., Conforti, L., Spencer, J. P., Williams, R. J., Bendotti, C. and Rattray, M., 2004. Expression of SOD1 G93A or wild-type SOD1 in primary cultures of astrocytes down-regulates the glutamate transporter GLT-1:lack of involvement of oxidative stress. Journal of Neurochemistry, 88 (2), pp. 481-93.

Williams, R. J., Spencer, J. P. E., Goni, F. M. and Rice-Evans, C. A., 2004. Zinc-histidine complex protects cultured cortical neurons against oxidative stress-induced damage. Neuroscience Letters, 371 (2-3), pp. 106-10.


Spencer, J. P. E., Kuhnle, G. G. C., Williams, R. J. and Rice-Evans, C., 2003. Intracellular metabolism and bioactivity of quercetin and its in vivo metabolites. Biochemical Journal, 372 (1), pp. 173-81.

Suchak, S. K., Baloyianni, N. V., Perkinton, M. S., Williams, R. J., Meldrum, B. S. and Rattray, M., 2003. The 'glial' glutamate transporter, EAAT2 (Glt-1) accounts for high affinity glutamate uptake into adult rodent nerve endings. Journal of Neurochemistry, 84 (3), pp. 522-32.


Schroeter, H., Boyd, C., Spencer, J. P. E., Williams, R. J., Cadenas, E. and Rice-Evans, C., 2002. MAPK signaling in neurodegeneration:influences of flavonoids and of nitric oxide. Neurobiology of Aging, 23 (5), pp. 861-80.

Pezet, S., Malcangio, M., Lever, I. J., Perkinton, M. S., Thompson, S. W. N., Williams, R. J. and McMahon, S. B., 2002. Noxious stimulation induces Trk receptor and downstream ERK phosphorylation in spinal dorsal horn. Molecular and Cellular Neuroscience, 21 (4), pp. 684-95.

Perkinton, M. S., Ip, J. K., Wood, G. L., Crossthwaite, A. J. and Williams, R. J., 2002. Phosphatidylinositol 3-kinase is a central mediator of NMDA receptor signalling to MAP kinase (Erk1/2), Akt/PKB and CREB in striatal neurones. Journal of Neurochemistry, 80 (2), pp. 239-54.


Spencer, J. P., Schroeter, H., Crossthwaithe, A. J., Kuhnle, G., Williams, R. J. and Rice-Evans, C., 2001. Contrasting influences of glucuronidation and O-methylation of epicatechin on hydrogen peroxide-induced cell death in neurons and fibroblasts. Free Radical Biology and Medicine, 31 (9), pp. 1139-46.


Schroeter, H., Williams, R. J., Matin, R., Iversen, L. and Rice-Evans, C. A., 2000. Phenolic antioxidants attenuate neuronal cell death following uptake of oxidized low-density lipoprotein. Free Radical Biology and Medicine, 29 (12), pp. 1222-33.



Molloy, G. Y., Rattray, M. and Williams, R. J., 1998. Genes encoding multiple forms of phospholipase A2 are expressed in rat brain. Neuroscience Letters, 258 (3), pp. 139-142.

Samanta, S., Perkinton, M. S., Morgan, M. and Williams, R. J., 1998. Hydrogen peroxide enhances signal-responsive arachidonic acid release from neurons:role of mitogen-activated protein kinase. Journal of Neurochemistry, 70 (5), pp. 2082-2090.

Akbar, M. T., Rattray, M., Williams, R. J., Chong, N. W. and Meldrum, B. S., 1998. Reduction of GABA and glutamate transporter messenger RNAs in the severe-seizure genetically epilepsy-prone rat. Neuroscience, 85 (4), pp. 1235-1251.


Navamani, M., Morgan, M. and Williams, R. J., 1997. Ethanol modulates N-methyl-D-aspartate-evoked arachidonic acid release from neurones. European Journal of Pharmacology, 340 (1), pp. 27-34.


Williams, R. J. and Glowinski, J., 1996. Cyclothiazide unmasks an AMPA-evoked release of arachidonic acid from cultured striatal neurones. Journal of Neurochemistry, 67 (4), pp. 1551-1558.

Williams, R. J., Maus, M., Stella, N., Glowinski, J. and Premont, J., 1996. Reduced glucose metabolism enhances the glutamate-evoked release of arachidonic acid from striatal neurons. Neuroscience, 74 (2), pp. 461-468.


Williams, R. J., Murphy, N., Glowinski, J. and Prémont, J., 1995. Glucose regulates glutamate-evoked arachidonic acid release from cultured striatal neurons. Journal of Neurochemistry, 65 (1), pp. 241-249.

Williams, R. J. and Kelly, E., 1995. Measurement of adenylyl cyclase activity in cell membranes. In: Kendall, D. A. and Hill, S. J., eds. Signal Transduction Protocols. Totowa, USA: Humana Press, pp. 63-77. (Methods in Molecular Biology; 41)



Williams, R. J. and Kelly, E., 1993. Chronic Ethanol Reduces Immunologically Detectable Gqα/11α in NG108–15 Cells. Journal of Neurochemistry, 61 (3), pp. 1163-1166.

Williams, R. J., Veale, M. A. and Kelly, E., 1993. Involvement of adenosine in ethanol-induced changes in G-protein expression in NG108-15 cells? Alcohol and Alcoholism: Supplement, 2, pp. 431-435.


Bramley, T. A., Menzies, G. S., Williams, R. J., Kinsman, O. S. and Adams, D. J., 1991. Binding sites for LH in Candida albicans:comparison with the mammalian corpus luteum LH receptor. Journal of Endocrinology, 130 (2), pp. 177-190.


Williams, R. J., Dickinson, K., Kinsman, O. S., Bramley, T. A., Menzies, G. S. and Adams, D. J., 1990. Receptor-mediated elevation of adenylate cyclase by luteinizing hormone in Candida albicans. Journal of General Microbiology, 136 (11), pp. 2143-2148.

Bramley, T. A., Menzies, G. S., Williams, R. J., Kinsman, O. S. and Adams, D. J., 1990. Specific, high-affinity binding sites for human luteinizing hormone (hLH) and human chorionic gonadotrophin (hCG) in Candida species. Biochemical and Biophysical Research Communications, 167 (3), pp. 1050-1056.

This list was generated on Wed Jun 20 14:02:07 2018 IST.