Research

Items by Williams, Dr Robert J

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Number of items: 60.

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Williams, R. J. and Kelly, E., 1995. Measurement of adenylyl cyclase activity in cell membranes. In: Kendall, D. A. and Hill, S. J., eds. Signal Transduction Protocols. Totowa, USA: Humana Press, pp. 63-77. (Methods in Molecular Biology; 41)

Articles

Tan, M. G. K., Lee, C., Lee, J. H., Francis, P. T., Williams, R. J., Ramírez, M. J., Chen, C. P., Wong, P. T.-H. and Lai, M. K. P., 2014. Decreased rabphilin 3A immunoreactivity in Alzheimer's disease is associated with Aβ burden. Neurochemistry International, 64, pp. 29-36.

Hoey, S. E., Buonocore, F., Cox, C. J., Hammond, V. J., Perkinton, M. S. and Williams, R. J., 2013. AMPA receptor activation promotes non-amyloidogenic amyloid precursor protein processing and suppresses neuronal amyloid-β production. PLoS ONE, 8 (10), e78155.

Pereira Morais, M. P., Marshall, D., Flower, S. E., Caunt, C. J., James, T. D., Williams, R. J., Waterfield, N. R. and Van Den Elsen, J. M. H., 2013. Analysis of protein glycation using fluorescent phenylboronate gel electrophoresis. Scientific Reports, 3, 1437.

Guadagna, S., Esiri, M. M., Williams, R. J. and Francis, P. T., 2012. Tau phosphorylation in human brain: relationship to behavioral disturbance in dementia. Neurobiology of Aging, 33 (12), pp. 2798-2806.

Bahia, P. K., Pugh, V., Hoyland, K., Hensley, V., Rattray, M. and Williams, R. J., 2012. Neuroprotective effects of phenolic antioxidant tBHQ associate with inhibition of FoxO3a nuclear translocation and activity. Journal of Neurochemistry, 123 (1), pp. 182-191.

McHugh, P. C., Wright, J. A., Williams, R. J. and Brown, D. R., 2012. Prion protein expression alters APP cleavage without interaction with BACE-1. Neurochemistry International, 61 (5), pp. 672-680.

Choudhry, F., Howlett, D. R., Richardson, J. C., Francis, P. T. and Williams, R. J., 2012. Pro-oxidant diet enhances β/γ secretase-mediated APP processing in APP/PS1 transgenic mice. Neurobiology of Aging, 33 (5), pp. 960-968.

Spencer, J. P. E., Vafeiadou, K., Williams, R. J. and Vauzour, D., 2012. Neuroinflammation: Modulation by flavonoids and mechanisms of action. Molecular Aspects of Medicine, 33 (1), pp. 83-97.

Williams, R. J. and Spencer, J. P. E., 2012. Flavonoids, cognition, and dementia: Actions, mechanisms, and potential therapeutic utility for Alzheimer disease. Free Radical Biology & Medicine, 52 (1), pp. 35-45.

Gaeta, A., Molina-Holgado, F., Kong, X. L., Salvage, S., Fakih, S., Francis, P. T., Williams, R. J. and Hider, R. C., 2011. Synthesis, physical-chemical characterisation and biological evaluation of novel 2-amido-3-hydroxypyridin-4(1H)-ones: Iron chelators with the potential for treating Alzheimer's disease. Bioorganic & Medicinal Chemistry, 19 (3), pp. 1285-97.

Thambisetty, M., Simmons, A., Velayudhan, L., Hye, A., Campbell, J., Zhang, Y., Wahlund, L.-O., Westman, E., Guntert, A., Kinsey, A., Proitsi, P., Powell, J., Causevic, M., Killick, R., Lunnon, K., Lynham, S., Broadstock, M., Choudhry, F., Howlett, D., Williams, R., Sharp, S., Mitchlemore, C., Tunnard, C., Leung, R., Foy, C., O'Brien, D., Breen, G., Furney, S., Ward, M., Kloszewska, I., Mecocco, P., Soininen, H., Tsolaki, M., Vellas, B., Hodges, A., Murphy, D., Parkins, S., Richardson, J., Resnik, S., Ferrucci, L., Wong, D., Zhou, Y., Muehlboeck, S., Evans, A., Francis, P., Spenger, C. and Lovestone, S., 2010. Association of plasma clusterin concentration with severity, pathology, and progression in Alzheimer disease. Archives of General Psychiatry, 67 (7), pp. 739-748.

Rainey-Smith, S. R., Andersson, D. A., Williams, R. J. and Rattray, M., 2010. Tumour necrosis factor alpha induces rapid reduction in AMPA receptor-mediated calcium entry in motor neurones by increasing cell surface expression of the GluR2 subunit: relevance to neurodegeneration. Journal of Neurochemistry, 113 (3), pp. 692-703.

Hoey, S. E., Williams, R. J. and Perkinton, M. S., 2009. Synaptic NMDA receptor activation stimulates α-secretase amyloid precursor protein processing and inhibits amyloid-β production. The Journal of Neuroscience: The Official Journal of the Society for Neuroscience, 29 (14), pp. 4442-4460.

Vafeiadou, K., Vauzour, D., Lee, H. Y., Rodriguez-Mateos, A., Williams, R. J. and Spencer, J. P. E., 2009. The citrus flavanone naringenin inhibits inflammatory signalling in glial cells and protects against neuroinflammatory injury. Archives of Biochemistry and Biophysics, 484 (1), pp. 100-109.

Vafeiadou, K., Vauzour, D., Rodriguez-Mateos, A., Whiteman, M., Williams, R. and Spencer, J., 2008. Glial metabolism of quercetin reduces its neurotoxic potential. Archives of Biochemistry and Biophysics, 478 (2), pp. 195-200.

Bahia, P. K., Rattray, M. and Williams, R. J., 2008. Dietary flavonoid (-)epicatechin stimulates phosphatidylinositol 3-kinase-dependent anti-oxidant response element activity and up-regulates glutathione in cortical astrocytes. Journal of Neurochemistry, 106 (5), pp. 2194-2204.

Abbott, J. J., Howlett, D. R., Francis, P. T. and Williams, R. J., 2008. Aβ1-42 modulation of Akt phosphorylation via α7 nAChR and NMDA receptors. Neurobiology of Aging, 29 (7), pp. 992-1001.

Rainey-Smith, S., Schroetke, L.-W., Bahia, P., Fahmi, A., Skilton, R., Spencer, J. P. E., Rice-Evans, C., Rattray, M. and Williams, R. J., 2008. Neuroprotective effects of hesperetin in mouse primary neurones are independent of CREB activation. Neuroscience Letters, 438 (1), pp. 29-33.

Pezet, S., Marchand, F., D'Mello, R., Grist, J., Clark, A. K., Malcangio, M., Dickenson, A. H., Williams, R. J. and McMahon, S. B., 2008. Phosphatidylinositol 3-kinase is a key mediator of central sensitization in painful inflammatory conditions. The Journal of Neuroscience: The Official Journal of the Society for Neuroscience, 28 (16), pp. 4261-4270.

Molina-Holgado, F., Gaeta, A., Francis, P. T., Williams, R. J. and Hider, R. C., 2008. Neuroprotective actions of deferiprone in cultured cortical neurones and SHSY-5Y cells. Journal of Neurochemistry, 105 (6), pp. 2466-2476.

Schroeter, H., Bahia, P., Spencer, J. P. E., Sheppard, O., Rattray, M., Cadenas, E., Rice-Evans, C. and Williams, R. J., 2007. (-)Epicatechin stimulates ERK-dependent cyclic AMP response element activity and up-regulates GluR2 in cortical neurons. Journal of Neurochemistry, 101 (6), pp. 1596-1606.

Vauzour, D., Vafeiadou, K., Rice-Evans, C., Williams, R. J. and Spencer, J. P. E., 2007. Activation of pro-survival Akt and ERK1/2 signalling pathways underlie the anti-apoptotic effects of flavanones in cortical neurons. Journal of Neurochemistry, 103 (4), pp. 1355-67.

Molina-Holgado, F., Rubio-Araiz, A., García-Ovejero, D., Williams, R. J., Moore, J. D., Arévalo-Martín, A., Gómez-Torres, O. and Molina-Holgado, E., 2007. CB2 cannabinoid receptors promote mouse neural stem cell proliferation. European Journal of Neuroscience, 25 (3), pp. 629-34.

Molina-Holgado, F., Hider, R. C., Gaeta, A., Williams, R. and Francis, P., 2007. Metals ions and neurodegeneration. Biometals, 20 (3-4), pp. 639-54.

Jacobs, E. H., Williams, R. and Francis, P. T., 2006. Cyclin-dependent kinase 5, Munc18a and Munc18-interacting protein 1/X11alpha protein up-regulation in Alzheimer's disease. Neuroscience, 138 (2), pp. 511-22.

Hayat, S., Williams, R. J. and Rattray, M., 2006. Serotonin transporter expression is not sufficient to confer cytotoxicity to 3,4-methylenedioxymethamphetamine (MDMA) in vitro. Journal of Psychopharmacology, 20 (2), pp. 257-63.

Pezet, S., Spyropoulos, A., Williams, R. J. and McMahon, S. B., 2005. Activity-dependent phosphorylation of Akt/PKB in adult DRG neurons. European Journal of Neuroscience, 21 (7), pp. 1785-97.

Williams, R. J., Spencer, J. P. E. and Rice-Evans, C., 2004. Flavonoids: antioxidants or signalling molecules? Free Radical Biology and Medicine, 36 (7), pp. 838-849.

Tortarolo, M., Crossthwaite, A. J., Conforti, L., Spencer, J. P., Williams, R. J., Bendotti, C. and Rattray, M., 2004. Expression of SOD1 G93A or wild-type SOD1 in primary cultures of astrocytes down-regulates the glutamate transporter GLT-1 : lack of involvement of oxidative stress. Journal of Neurochemistry, 88 (2), pp. 481-93.

Crossthwaite, A. J., Valli, H. and Williams, R. J., 2004. Inhibiting Src family tyrosine kinase activity blocks glutamate signalling to ERK1/2 and Akt/PKB but not JNK in cultured striatal neurones. Journal of Neurochemistry, 88 (5), pp. 1127-39.

Williams, R. J., Spencer, J. P. E., Goni, F. M. and Rice-Evans, C. A., 2004. Zinc-histidine complex protects cultured cortical neurons against oxidative stress-induced damage. Neuroscience Letters, 371 (2-3), pp. 106-10.

Spencer, J. P. E., Rice-Evans, C. and Williams, R. J., 2003. Modulation of pro-survival Akt/Protein Kinase B and ERK1/2 signaling cascades by quercetin and its in vivo metabolites underlie their action on neuronal viability. Journal of Biological Chemistry, 278 (37), pp. 34783-34793.

Spencer, J. P. E., Kuhnle, G. G. C., Williams, R. J. and Rice-Evans, C., 2003. Intracellular metabolism and bioactivity of quercetin and its in vivo metabolites. Biochemical Journal, 372 (1), pp. 173-81.

Suchak, S. K., Baloyianni, N. V., Perkinton, M. S., Williams, R. J., Meldrum, B. S. and Rattray, M., 2003. The 'glial' glutamate transporter, EAAT2 (Glt-1) accounts for high affinity glutamate uptake into adult rodent nerve endings. Journal of Neurochemistry, 84 (3), pp. 522-32.

Crossthwaite, A. J., Hasan, S. and Williams, R. J., 2002. Hydrogen peroxide-mediated phosphorylation of ERK1/2, Akt/PKB and JNK in cortical neurones : dependence on Ca(2+) and PI3-kinase. Journal of Neurochemistry, 80 (1), pp. 24-35.

Schroeter, H., Boyd, C., Spencer, J. P. E., Williams, R. J., Cadenas, E. and Rice-Evans, C., 2002. MAPK signaling in neurodegeneration : influences of flavonoids and of nitric oxide. Neurobiology of Aging, 23 (5), pp. 861-80.

Pezet, S., Malcangio, M., Lever, I. J., Perkinton, M. S., Thompson, S. W. N., Williams, R. J. and McMahon, S. B., 2002. Noxious stimulation induces Trk receptor and downstream ERK phosphorylation in spinal dorsal horn. Molecular and Cellular Neuroscience, 21 (4), pp. 684-95.

Perkinton, M. S., Ip, J. K., Wood, G. L., Crossthwaite, A. J. and Williams, R. J., 2002. Phosphatidylinositol 3-kinase is a central mediator of NMDA receptor signalling to MAP kinase (Erk1/2), Akt/PKB and CREB in striatal neurones. Journal of Neurochemistry, 80 (2), pp. 239-54.

Spencer, J. P., Schroeter, H., Crossthwaithe, A. J., Kuhnle, G., Williams, R. J. and Rice-Evans, C., 2001. Contrasting influences of glucuronidation and O-methylation of epicatechin on hydrogen peroxide-induced cell death in neurons and fibroblasts. Free Radical Biology and Medicine, 31 (9), pp. 1139-46.

Schroeter, H., Spencer, J. P., Rice-Evans, C. and Williams, R. J., 2001. Flavonoids protect neurons from oxidized low-density-lipoprotein-induced apoptosis involving c-Jun N-terminal kinase (JNK), c-Jun and caspase-3. Biochemical Journal, 358 (3), pp. 547-57.

Schroeter, H., Williams, R. J., Matin, R., Iversen, L. and Rice-Evans, C. A., 2000. Phenolic antioxidants attenuate neuronal cell death following uptake of oxidized low-density lipoprotein. Free Radical Biology and Medicine, 29 (12), pp. 1222-33.

Perkinton, M. S., Sihra, T. S. and Williams, R. J., 1999. Ca(2+)-permeable AMPA receptors induce phosphorylation of cAMP response element-binding protein through a phosphatidylinositol 3-kinase-dependent stimulation of the mitogen-activated protein kinase signaling cascade in neurons. Journal of Neuroscience, 19 (14), pp. 5861-74.

Molloy, G. Y., Rattray, M. and Williams, R. J., 1998. Genes encoding multiple forms of phospholipase A2 are expressed in rat brain. Neuroscience Letters, 258 (3), pp. 139-142.

Samanta, S., Perkinton, M. S., Morgan, M. and Williams, R. J., 1998. Hydrogen peroxide enhances signal-responsive arachidonic acid release from neurons : role of mitogen-activated protein kinase. Journal of Neurochemistry, 70 (5), pp. 2082-2090.

Akbar, M. T., Rattray, M., Williams, R. J., Chong, N. W. and Meldrum, B. S., 1998. Reduction of GABA and glutamate transporter messenger RNAs in the severe-seizure genetically epilepsy-prone rat. Neuroscience, 85 (4), pp. 1235-1251.

Navamani, M., Morgan, M. and Williams, R. J., 1997. Ethanol modulates N-methyl-D-aspartate-evoked arachidonic acid release from neurones. European Journal of Pharmacology, 340 (1), pp. 27-34.

Williams, R. J. and Glowinski, J., 1996. Cyclothiazide unmasks an AMPA-evoked release of arachidonic acid from cultured striatal neurones. Journal of Neurochemistry, 67 (4), pp. 1551-1558.

Williams, R. J., Maus, M., Stella, N., Glowinski, J. and Premont, J., 1996. Reduced glucose metabolism enhances the glutamate-evoked release of arachidonic acid from striatal neurons. Neuroscience, 74 (2), pp. 461-468.

Kelly, E., Harrison, P. K. and Williams, R. J., 1995. Effects of acute and chronic ethanol on cyclic AMP accumulation in NG108-15 cells : differential dependence of changes on extracellular adenosine. British Journal of Pharmacology, 114 (7), pp. 1433-1441.

Williams, R. J., Murphy, N., Glowinski, J. and Prémont, J., 1995. Glucose regulates glutamate-evoked arachidonic acid release from cultured striatal neurons. Journal of Neurochemistry, 65 (1), pp. 241-249.

Donnelly, L. E., Boyd, R. S., Williams, R. J., Kelly, E. and MacDermot, J., 1995. Inhibition of ADP-ribosyltransferase increases synthesis of Gs alpha in neuroblastoma x glioma hybrid cells and reverses iloprost-dependent heterologous loss of fluoride-sensitive adenylate cyclase. Biochemical Pharmacology, 49 (6), pp. 767-776.

Williams, R. J. and Kelly, E., 1994. Gsα-dependent and -independent desensitisation of prostanoid IP receptor-activated adenylyl cyclase in NG108-15 cells. European Journal of Pharmacology, 268 (2), pp. 177-186.

Williams, R. J. and Kelly, E., 1993. Chronic Ethanol Reduces Immunologically Detectable Gqα/11α in NG108–15 Cells. Journal of Neurochemistry, 61 (3), pp. 1163-1166.

Williams, R. J., Veale, M. A., Horne, P. and Kelly, E., 1993. Ethanol differentially regulates guanine nucleotide-binding protein alpha subunit expression in NG108-15 cells independently of extracellular adenosine. Molecular Pharmacology, 43 (2), pp. 158-166.

Williams, R. J., Veale, M. A. and Kelly, E., 1993. Involvement of adenosine in ethanol-induced changes in G-protein expression in NG108-15 cells? Alcohol and Alcoholism: Supplement, 2, pp. 431-435.

Bramley, T. A., Menzies, G. S., Williams, R. J., Kinsman, O. S. and Adams, D. J., 1991. Binding sites for LH in Candida albicans : comparison with the mammalian corpus luteum LH receptor. Journal of Endocrinology, 130 (2), pp. 177-190.

Bramley, T. A., Menzies, G. S., Williams, R. J., Kinsman, O. S. and Adams, D. J., 1991. Characterization of a factor(s) from partially purified human gonadotrophin preparations which inhibit(s) the binding of radiolabelled human LH and human chorionic gonadotrophin to Candida albicans. Journal of Endocrinology, 128 (1), pp. 139-151.

Williams, R. J., Dickinson, K., Kinsman, O. S., Bramley, T. A., Menzies, G. S. and Adams, D. J., 1990. Receptor-mediated elevation of adenylate cyclase by luteinizing hormone in Candida albicans. Journal of General Microbiology, 136 (11), pp. 2143-2148.

Bramley, T. A., Menzies, G. S., Williams, R. J., Kinsman, O. S. and Adams, D. J., 1990. Specific, high-affinity binding sites for human luteinizing hormone (hLH) and human chorionic gonadotrophin (hCG) in Candida species. Biochemical and Biophysical Research Communications, 167 (3), pp. 1050-1056.

This list was generated on Mon Oct 20 00:03:12 2014 IST.