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Items by Thompson, Andrew

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Number of items: 24.

2013

Nathubhai, A., Wood, P. J., Lloyd, M. D., Thompson, A. S. and Threadgill, M. D., 2013. Design and discovery of 2‑arylquinazolin-4-ones as potent and selective inhibitors of tankyrases. ACS Medicinal Chemistry Letters, 4 (12), pp. 1173-1177.

Qu, X., Allan, A., Chui, G., Hutchings, T. J., Jiao, P., Johnson, L., Leung, W. Y., Li, P. K., Steel, G. R., Thompson, A. S., Threadgill, M. D., Woodman, T. J. and Lloyd, M. D., 2013. Hydrolysis of ibuprofenoyl-CoA and other 2-APA-CoA esters by human acyl-CoA thioesterases-1 and -2 and their possible role in the chiral inversion of profens. Biochemical Pharmacology, 86 (11), pp. 1621-1625.

Woon, E. C. Y., Sunderland, P. T., Paine, H. A., Lloyd, M. D., Thompson, A. S. and Threadgill, M. D., 2013. One-pot tandem Hurtley–retro-Claisen–cyclisation reactions in the synthesis of 3-substituted analogues of 5-aminoisoquinolin-1-one (5-AIQ), a water-soluble inhibitor of PARPs. Bioorganic and Medicinal Chemistry, 21 (17), pp. 5218-5227.

2011

Nathubhai, A., Patterson, R., Woodman, T. J., Sharp, H. E. C., Chui, M. T. Y., Chung, H. H. K., Lau, S. W. S., Zheng, J., Lloyd, M. D., Thompson, A. S. and Threadgill, M. D., 2011. N3-Alkylation during formation of quinazolin-4-ones from condensation of anthranilamides and orthoamides. Organic and Biomolecular Chemistry, 9 (17), pp. 6089-6099.

Woodman, T. J., Wood, P. J., Thompson, A. S., Hutchings, T. J., Steel, G. R., Jiao, P., Threadgill, M. D. and Lloyd, M. D., 2011. Chiral inversion of 2-arylpropionyl-CoA esters by human α-methylacyl-CoA racemase 1A (P504S)-a potential mechanism for the anti-cancer effects of ibuprofen. Chemical Communications, 47 (26), pp. 7332-7334.

Hopton, S. R. and Thompson, A. S., 2011. Nuclear magnetic resonance solution structures of inter- and intrastrand adducts of DNA cross-linker SJG-136. Biochemistry, 50 (21), pp. 4720-4732.

Hopton, S. R. and Thompson, A. S., 2011. Manipulative interplay of two adozelesin molecules with d(ATTAAT)2 achieving ligand-stacked Watson-Crick and Hoogsteen base-paired duplex adducts. Biochemistry, 50 (19), pp. 4143-4154.

Holbourn, K. P., Lloyd, M. D., Thompson, A. S., Threadgill, M. D. and Acharya, K. R., 2011. Cloning, purification, crystallization and preliminary crystallographic analysis of the human histone deacetylase sirtuin 1. Acta Crystallographica Section F-Structural Biology and Crystallization Communications, 67 (4), pp. 461-463.

Sunderland, P. T., Dhami, A., Mahon, M. F., Jones, L. A., Tully, S. R., Lloyd, M. D., Thompson, A. S., Javaid, H., Martin, N. M. B. and Threadgill, M. D., 2011. Synthesis of 4-alkyl-, 4-aryl- and 4-arylamino-5-aminoisoquinolin-1-ones and identification of a new PARP-2 selective inhibitor. Organic and Biomolecular Chemistry, 9 (3), pp. 881-891.

Sunderland, P. T., Woon, E. C. Y., Dhami, A., Bergin, A. B., Mahon, M. F., Wood, P. J., Jones, L. A., Tully, S. R., Lloyd, M. D., Thompson, A. S., Javaid, H., Martin, N. M. B. and Threadgill, M. D., 2011. 5-Benzamidoisoquinolin-1-ones and 5-(ω-Carboxyalkyl)isoquinolin-1-ones as Isoform-Selective Inhibitors of Poly(ADP-ribose) Polymerase 2 (PARP-2). Journal of Medicinal Chemistry, 54 (7), pp. 2049-2059.

2009

Rahman, K. M., Thompson, A. S., James, C. H., Narayanaswamy, M. and Thurston, D. E., 2009. The pyrrolobenzodiazepine dimer SJG-136 forms sequence-dependent intrastrand DNA cross-links and monoalkylated adducts in addition to interstrand cross-links. Journal of the American Chemical Society, 131 (38), pp. 13756-13766.

2007

El-Hamamsy, M. H. R. I., Smith, A. W., Thompson, A. S. and Threadgill, M. D., 2007. Structure-based design, synthesis and preliminary evaluation of selective inhibitors of dihydrofolate reductase from Mycobacterium tuberculosis. Bioorganic and Medicinal Chemistry, 15 (13), pp. 4552-4576.

Powell, C. L., Schulze, M., Black, S. J., Thompson, A. S. and Threadgill, M. D., 2007. Closo --> nido cage degradation of 1-(substituted-phenyl)-1,2-dicarbadodecaborane(12)s in wet DMSO under neutral conditions. Tetrahedron Letters, 48, pp. 1251-1254.

Sunderland, P. T., Thompson, A. S. and Threadgill, M. D., 2007. Formation of 3-aryl-5-nitroisocoumarins from 5-nitroisocoumarins and aromatic acyl chlorides under Friedel-Crafts conditions. Journal of Organic Chemistry, 72, pp. 7409-7412.

2004

Spruce, B. A., Campbell, L. A., McTavish, N., Cooper, M. A., Appleyard, M. V. L., O'Neill, M., Howie, J., Samson, J., Watt, S., Murray, K., McLean, D., Leslie, N. R., Safrany, S. T., Ferguson, M. J., Peters, J. A., Prescott, A. R., Box, G., Hayes, A., Nutley, B., Raynaud, F., Downes, C. P., Lambert, J. J., Thompson, A. M. and Eccles, S., 2004. Small molecule antagonists of the σ-1 receptor cause selective release of the death program in tumor and self-reliant cells and inhibit tumor growth in vitro and in vivo. Cancer Research, 64, pp. 4875-4886.

2003

Smellie, M., Bose, D. S., Thompson, A. S., Jenkins, T. C., Hartley, J. A. and Thurston, D. E., 2003. Sequence-selective recognition of duplex DNA through covalent interstrand cross-linking: kinetic and molecular modeling studies with pyrrolobenzodiazepine dimers. Biochemical Journal, 42 (27), pp. 8232-8239.

Frixa, C., Mahon, M. F., Thompson, A. S. and Threadgill, M. D., 2003. Synthesis of meso -substituted porphyrins carrying carboranes and oligo(ethylene glycol) units for potential applications in boron neutron capture therapy. Organic and Biomolecular Chemistry, 1 (2), pp. 306-317.

2002

Wong, S. M., Shah, B., Shah, P., Butt, I. C., Woon, E. C. Y., Wright, J. A., Thompson, A. S., Upton, C. and Threadgill, M. D., 2002. A new synthesis of "push-pull" naphthalenes by condensation of nitro-2-methylbenzoate esters with dimethylacetamide dimethyl acetal. Tetrahedron Letters, 43 (12), pp. 2299-2302.

Madani, H., Thompson, A. S. and Threadgill, M. D., 2002. An expedient synthesis of 7-0-functionalised pyrrolo[2,1-c][1,4]benzodiazepine-5,11-diones. Tetrahedron, 58 (40), pp. 8107-8111.

Frixa, C., Mahon, M. F., Thompson, A. S. and Threadgill, M. D., 2002. Direct Cu(I)-catalysed coupling of a carborane to a meso-tetraphenylporphyrin. Tetrahedron Letters, 43 (8), pp. 1557-1559.

Frixa, C., Scobie, M., Black, S. J., Thompson, A. S. and Threadgill, M. D., 2002. Formation of a remarkably robust 2:1 complex between β-cyclodextrin and a phenyl-substituted icosahedral carborane. Chemical Communications, 27, pp. 2876-2877.

2001

Wayman, N., McDonald, M. C., Thompson, A. S., Threadgill, M. D. and Thiemermann, C., 2001. 5-Aminoisoquinolinone, a potent inhibitor of poly(adenosine 5'-diphosphate ribose) polymerase, reduces myocardial infarct size. European Journal of Pharmacology, 430 (1), pp. 93-100.

2000

Cameron, L. and Thompson, A. S., 2000. Determination of the structural role of the linking moieties in the DNA binding of adozelesin. Biochemistry, 39 (17), pp. 5004-5012.

McDonald, M. C., Mota-Filipe, H., Wright, J. A., Abdelrahman, M., Threadgill, M. D., Thompson, A. S. and Thiemermann, C., 2000. Effects of 5-aminoisoquinolinone, a water-soluble, potent inhibitor of the activity of poly (ADP-ribose) polymerase on the organ injury and dysfunction caused by haemorrhagic shock. British Journal of Pharmacology, 130 (4), pp. 843-850.

This list was generated on Mon Dec 22 13:29:01 2014 GMT.