Items by Welham, Melanie

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Number of items: 40.


Storm, M.P., Kumpfmueller, B., Bone, H.K., Buchholz, M., Sanchez Ripoll, Y., Chaudhuri, J.B., Niwa, H., Tosh, D. and Welham, M.J., 2014. Zscan4 is regulated by PI3-kinase and DNA-damaging agents and directly interacts with the transcriptional repressors LSD1 and CtBP2 in mouse embryonic stem cells. PLoS ONE, 9 (3).

Doughton, G., Wei, J., Tapon, N., Welham, M. J. and Chalmers, A. D., 2014. Formation of a polarised primitive endoderm layer in embryoid bodies requires Fgfr/Erk signalling. PLoS ONE, 9 (4), e95434.

Turinetto, V., Orlando, L., Sanchez Ripoll, Y., Kumpfmueller, B., Storm, M. P., Porcedda, P., Minieri, V., Saviozzi, S., Accomasso, L., Cibrario Rocchietti, E., Moorwood, K., Circosta, P., Cignetti, A., Welham, M. J. and Giachino, C., 2012. High basal γH2AX levels sustain self-renewal of mouse embryonic and induced pluripotent stem cells. Stem Cells, 30 (7), pp. 1414-1423.

Thompson, B. A. N., Storm, M. P., Hewinson, J., Hogg, S., Welham, M. J. and Mackenzie, A. B., 2012. A novel role for P2X7 receptor signalling in the survival of mouse embryonic stem cells. Cellular Signalling, 24 (3), pp. 770-778.

Orlando, L., Sanchez Ripoll, Y., Foster, J., Bone, H., Giachino, C. and Welham, M. J., 2012. Differential coupling of self-renewal signaling pathways in murine induced pluripotent stem cells. PLoS ONE, 7 (1), e30234.

Bone, H. K., Nelson, A. S., Goldring, C. E., Tosh, D. and Welham, M. J., 2011. A novel chemically directed route for the generation of definitive endoderm from human embryonic stem cells based on inhibition of GSK-3. Journal of Cell Science, 124 (12), pp. 1992-2000.

Welham, M. J., Kingham, E., Sanchez Ripoll, Y., Kumpfmueller, B., Storm, M. and Bone, H., 2011. Controlling embryonic stem cell proliferation and pluripotency: the role of PI3K-and GSK-3-dependent signalling. Biochemical Society Transactions, 39 (2), pp. 674-678.

Storm, M. P., Orchard, C. B., Bone, H. K., Chaudhuri, J. B. and Welham, M. J., 2010. Three-dimensional culture systems for the expansion of pluripotent embryonic stem cells. Biotechnology and Bioengineering, 107 (4), pp. 683-695.

Mackenzie, A., Welham, M. and Thompson, B., 2010. Expression of ATP-gated P2X7 receptors in mouse embryonic stem cells. Purinergic Signalling, 6 (Supplement 1), p. 129.

Storm, M. P., Kumpfmueller, B., Thompson, B., Kolde, R., Vilo, J., Hummel, O., Schulz, H. and Welham, M. J., 2009. Characterization of the phosphoinositide 3-kinase-dependent transcriptome in murine embryonic stem cells : identification of novel regulators of pluripotency. Stem Cells, 27 (4), pp. 764-775.

Bone, H. K., Damiano, T., Bartlett, S., Perry, A., Letchford, J., Ripoli, Y. S., Nelson, A. S. and Welham, M. J., 2009. Involvement of GSK-3 in regulation of murine embryonic stem cell self-renewal revealed by a series of bisindolylmaleimides. Chemistry & Biology, 16 (1), pp. 15-27.

Martin-Fernandez, C., Bales, J., Hodgkinson, C., Welman, A., Welham, M. J., Dive, C. and Morrow, C. J., 2009. Blocking phosphoinositide 3-kinase activity in colorectal cancer cells reduces proliferation but does not increase apoptosis alone or in combination with cytotoxic drugs. Molecular Cancer Research, 7 (6), pp. 955-965.

Wei, J., Sanchez Ripoll, Y., Welham, M. and Chalmers, A. D., 2009. Bmp4 promotes differentiation of the first vertebrate epithelium. Mechanisms of Development, 126 (Suppl S), S271.

Kingham, E. and Welham, M., 2009. Distinct roles for isoforms of the catalytic subunit of class-IA PI3K in the regulation of behaviour of murine embryonic stem cells. Journal of Cell Science, 122 (13), pp. 2311-2321.

Schulz, H., Kolde, R., Adler, P., Aksoy, I., Anastassiadis, K., Bader, M., Billon, N., Boeuf, H., Bourillot, P., Buchholz, F., Dani, C., Doss, M. X., Forrester, L., Gitton, M., Henrique, D., Hescheler, J., Himmelbauer, H., Hübner, N., Karantzali, E., Kretsovali, A., Lubitz, S., Pradier, L., Rai, M., Reimand, J., Rolletschek, A., Sachinidis, A., Savatier, P., Stewart, F., Storm, M. P., Trouillas, M., Vilo, J., Welham, M. J., Winkler, J., Wobus, A. M., Hatzopoulos, A. K., Sham, M. H. and , T. F. C., 2009. The FunGenES database: a genomics resource for mouse embryonic stem cell differentiation. PLoS ONE, 4 (9), e6804.

Dobbin, E., Corrigan, P. M., Walsh, C. P., Welham, M. J., Freeburn, R. W. and Wheadon, H., 2008. Tel/PDGFR beta inhibits self-renewal and directs myelomonocytic differentiation of ES cells. Leukemia Research, 32 (10), pp. 1554-1564.

Akasaka, T., Balasas, T., Russell, L. J., Sugimoto, K. J., Majid, A., Walewska, R., Karran, E. L., Brown, D. G., Cain, K., Harder, L., Gesk, S., Martin-Subero, J. I., Atherton, M. G., Brüggemann, M., Calasanz, M. J., Davies, T., Haas, O. A., Hagemeijer, A., Kempski, H., Lessard, M., Lillington, D. M., Moore, S., Nguyen-Khac, F., Radford-Weiss, I., Schoch, C., Struski, S., Talley, P., Welham, M. J., Worley, H., Strefford, J. C., Harrison, C. J., Siebert, R. and Dyer, M. J. S., 2007. Five members of the CEBP transcription factor family are targeted by recurrent IGH translocations in B-cell precursor acute lymphoblastic leukemia (BCP-ALL). Blood, 109 (8), pp. 3451-3461.

Foster, S. R., Pearce, A., Blake, A. J., Welham, M. J. and Dowden, J., 2007. Novel octavalent cross-linker displays efficient trapping of protein protein interactions. Chemical Communications

Bone, H. K. and Welham, M. J., 2007. Phosphoinositide 3-kinase signalling regulates early development and developmental haemopoiesis. Journal of Cell Science, 120 (10), pp. 1752-1762.

Welham, M. J., Storm, M. P., Kingham, E. and Bone, H. K., 2007. Phosphoinositide 3-kinases and regulation of embryonic stem cell fate. Biochemical Society Transactions, 35 (2), pp. 225-228.

Storm, M. P., Bone, H. K., Beck, C. G., Bourillot, P. Y., Schreiber, V., Damiano, T., Nelson, A., Savatier, P. and Welham, M. J., 2007. Regulation of Nanog expression by phophoinositide-3-kinase-dependent signalling in murine embryonic stem cells. Journal of Biological Chemistry, 282 (9), pp. 6265-6273.

Crabbe, T., Welham, M. and Ward, S., 2007. The PI3K inhibitor arsenal: choose your weapon! Trends in Biochemical Sciences, 32 (10), pp. 450-456.

Welham, M. J., 2006. Embryonic stem cells - past, present, future. The Biochemist, 28, pp. 25-28.

Letchford, J., Cardwell, A. M., Stewart, K., Coogans, K. K. S., Cox, J. P. L., Lee, M., Beresford, J. N., Perry, M. J. and Welham, M. J., 2006. Isolation of C15: A novel antibody generated against mesenchymal stem cell-enriched adult human marrow. Journal of Immunological Methods, 308 (1-2), pp. 124-137.

Parry, R. V., Whittaker, G. C., Sims, M., Edmead, C., Welham, M. J. and Ward, S. G., 2006. Ligation of CD28 stimulates the formation of a multimeric signaling complex involving Grb-2-Associated binder 2 (Gab2), Src homology phosphatase-2, and phosphatidylinositol 3-kinase: evidence that negative regulation of CD28 signaling requires the Gab2 pleckstrin homology domain. The Journal of Immunology, 176, pp. 594-602.

Edmead, C. E., Fox, B. C., Stace, C., Ktistakis, N. and Welham, M. J., 2006. The pleckstrin homology domain of Gab-2 is required for optimal interleukin-3 signalsome-mediated responses. Cellular Signalling, 18 (8), pp. 1147-1155.

Wright, K. L., Rooney, N., Feeney, M., Tate, J., Robertson, D., Welham, M. J. and Ward, S. G., 2005. Differential expression of cannabinoid receptors in the human colon: cannabinoids promote epithelial wound healing. Gastroenterology, 129 (2), pp. 437-453.

Fox, B. C., Crew, T. E. and Welham, M. J., 2005. Phosphoinositide 3-kinases can act independently of p27 Kip1 to regulate optimal IL-3-dependent cell cycle progression and proliferation. Cellular Signalling, 17, pp. 473-487.

Paling, N. R. D. and Welham, M. J., 2005. Tyrosine phosphatase SHP-1 acts at different stages of development to regulate hematopoieses. Blood, 105 (11), pp. 4290-4297.

Paling, N. R. D., Wheadon, H., Bone, H. K. and Welham, M. J., 2004. Regulation of embryonic stem cell self-renewal by phosphoinositide 3-kinase-dependent signaling. Journal of Biological Chemistry, 279 (46), pp. 48063-48070.

Letchford, J., Cardwell, A., Lee, M., Beresford, J. N., Welham, M. J. and Perry, M. J., 2004. The generation of antibodies against adult human mesenchymal stem cells by phage display. Journal of Bone and Mineral Research, 19 (6), p. 1045.

Welham, M. J., 2004. VAP-1: a new anti-inflammatory target? Blood, 103 (9), pp. 3250-3251.

Ward, S. G., Finan, P. and Welham, M. J., 2003. P13K comes of age. Nature Immunology, 4 (1), p. 2.

Wheadon, H., Edmead, C. E. and Welham, M. J., 2003. Regulation of interleukin -3-induced substrate phosphorylation and cell survival by the tyrosine phosphatase SHP-2 (Src-homology protein tyrosine phosphatase). Biochemical Journal, 376 (1), pp. 147-157.

Wheadon, H. and Welham, M. J., 2003. The coupling of TEL/PDGFBR to distinct functional responses is modulated by the presence of cytokine: involvement of mitogen-activated protein kinases. Blood, 102 (4), pp. 1480-1489.

Wheadon, H., Paling, N. R. D. and Welham, M. J., 2002. Molecular interactions of SHP1 and SHP2 in IL-3-signalling. Cellular Signalling, 14, pp. 219-229.

Paling, N. R. D. and Welham, M. J., 2002. Role of the tyrosine phosphatase SHP-1 (Src homology phosphatase-1) in the regulation of interleukin-3-induced survival, proliferation and signalling. Biochemical Journal, 368, pp. 885-894.

Craddock, B. L., Hobbs, J., Edmead, C. E. and Welham, M. J., 2001. Phosphoinositide 3-kinase-dependent regulation of interleukin-3-induced proliferation: involvement of mitogen-activated protein kinases, SHP2 and Gab2. Journal of Biological Chemistry, 276 (26), pp. 24274-24283.

Patel, N., Craddock, B. L., Staniforth, J. N., Tobyn, M. J. and Welham, M. J., 2001. Spray-dried insulin particles retain biological activity in rapid in-vitro assay. Journal of Pharmacy and Pharmacology, 53, pp. 1415-1418.


Dowden, J. and Welham, M., 2007. Reagents and Methods for Cross-Linking Biological Molecules. C07D207/46-WO2007113575 (A2), 11 October 2007.

This list was generated on Sat Mar 28 05:20:51 2015 GMT.