Research

Items by Morley, Professor Bernard J

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Number of items: 59.

Book/s

Morley, B. J. and Walport, M., eds., 2000. The Complement Factsbook. London: Academic Press.

Book Sections

Morley, B. J., 2000. Factor I. In: Morley, B. J. and Walport, M., eds. The Complement FactsBook. London: Academic Press, pp. 83-86.

Vyse, T. J. and Morley, B. J., 2000. The analysis of genetic susceptibility. In: Lechler, R. and Warrens, A., eds. HLA in Health and Disease.6 ed. London: Academic Press, pp. 107-128.

Articles

Gabriel, L., Morley, B. J. and Rogers, N., 2009. The role of iNKT cells in the immunopathology of systemic lupus erythematosus. Annals of the New York Academy of Sciences, 1173 (Contemporary Challen), pp. 435-441.

Yoshinobu, K., Baudino, L., Santiago-Raber, M., Morito, N., Dunand-Sauthier, I., Morley, B. J., Evans, L. and Izui, S., 2009. Selective up-regulation of intact, but not defective env RNAs of endogenous modified polytropic retrovirus by the Sgp3 locus of lupus-prone mice. The Journal of Immunology, 182, pp. 8094-8103.

Rogers, N., Lees, M., Gabriel, L., Maniati, E., Rose, S., Potter, P. and Morley, B. J., 2009. A defect in Marco expression contributes to systemic lupus erythematosus development via failure to clear apoptotic cells. The Journal of Immunology, 182, pp. 1982-1990.

Baudino, L., Yoshinobu, K., Morito, N., Kikuchi, S., Fossati-Jimack, L., Morley, B. J., Vyse, T., Hirose, S., Jorgensen, T., Tucker, R., Roark, C., Kotzin, B., Evans, L. and Izui, S., 2008. Dissection of genetic mechanisms governing the expression of serum retroviral gp70 implicated in murine lupus nephritis. The Journal of Immunology, 181, pp. 2846-2854.

Maniati, E., Potter, P., Rogers, N. and Morley, B. J., 2008. Control of apoptosis in autoimmunity. The Journal of Pathology, 214 (2), pp. 190-198.

Rogers, N., Gabriel, L., Nunes, C., Rose, S., Thiruudaian, V., Boyle, J. and Morley, B. J., 2007. Monocytosis in BXSB mice is due to epistasis between Yaa and the telomeric region of chromosome 1 but does not drive the disease process. Genes and Immunity, 8, pp. 619-627.

Haywood, M., Gabriel, L., Rose, S., Rogers, N., Izui, S. and Morley, B. J., 2007. BXSB/long-lived is a recombinant inbred strain containing powerful disease suppressor loci. The Journal of Immunology, 179, pp. 2428-2434.

Deacon, R., Thomas, C., Rawlins, J. and Morley, B. J., 2007. A comparison of the behavior of C57BL/6 and C57BL/10 mice. Behavioural Brain Research, 179 (2), pp. 239-247.

Rankin, J., Boyle, J., Rose, S., Gabriel, L., Lewis, M., Thiruudaian, V., Rogers, N., Izui, S. and Morley, B. J., 2007. The Bxs6 locus of BXSB mice is sufficient for high-level expression of gp70 and the production of gp70 immune complexes. The Journal of Immunology, 178, pp. 4395-4401.

Haywood, M., Rose, S., Horswell, S., Lees, M., Fu, G., Walport, M. and Morley, B. J., 2006. Overlapping BXSB congenic intervals, in combination with microarray gene expression, reveal novel lupus candidate genes. Genes and Immunity, 7, pp. 250-263.

Rogers, N., Nunes, C., Rose, S. and Morley, B. J., 2005. Monocytosis in a murine model of SLE maps to the bottom of chromosome 1. Immunology, 116 (Suppl. 1), p. 10.

Choi, P., Xanthaki, D., Rose, S., Haywood, M., Reiser, H. and Morley, B. J., 2005. Linkage analysis of the genetic determinants of T-cell IL-4 secretion, and identification of Flj20274 as a putative candidate gene. Genes and Immunity, 6, pp. 290-297.

Haywood, M., Rogers, N., Rose, S., Boyle, J., McDermott, A., Rankin, J., Thiruudaian, V., Lewis, M., Fossati-Jimack, L., Izui, S., Walport, M. and Morley, B. J., 2004. Dissection of BXSB lupus phenotype using mice congenic for chromosome 1 demonstrates that separate intervals direct different aspects of disease. The Journal of Immunology, 173, pp. 4277-4285.

Lee, N., Rigby, R., Gill, H., Boyle, J., Fossati-Jimack, L., Morley, B. J. and Vyse, T., 2004. Multiple loci are linked with anti-red blood cell antibody production in NZB mice − comparison with other phenotypes implies complex modes of action. Clinical And Experimental Immunology, 138, pp. 39-46.

Rigby, R., Rozzo, S., Gill, H., Fernandez-Hart, T., Morley, B. J., Izui, S., Kotzin, B. and Vyse, T., 2004. A novel locus regulates both retroviral glycoprotein 70 and anti-glycoprotein 70 antibody production in New Zealand mice when crossed with BALB/c. The Journal of Immunology, 172, pp. 5078-5085.

Fu, G., Haywood, M. and Morley, B. J., 2002. Representational difference analysis in a lupus-prone mouse strain results in the identification of an unstable region of the genome on chromosome 11. Nucleic Acids Research, 30, pp. 1394-1400.

Roberton, C., Morley, B. J. and Vyse, T., 2001. Fine mapping genes for Fc γ receptor II and III in systemic lupus erythematosus. The American Journal of Human Genetics, 69, p. 568.

Haywood, M., Vyse, T., McDermott, A., Thompson, E., Ida, A., Walport, M., Izui, S. and Morley, B. J., 2001. Autoantigen glycoprotein 70 expression is regulated by a single locus, which acts as a checkpoint for pathogenic anti-glycoprotein 70 autoantibody production and hence for the corresponding development of severe nephritis, in lupus-prone PXSB mice. The Journal of Immunology, 167, pp. 1728-1733.

Stocker, C., Sugars, K., Yarwood, H., Delikouras, A., Lechler, R., Dorling, A., Landis, R., Morley, B. J. and Haskard, D., 2000. Cloning of porcine intercellular adhesion molecule-1 and characterization of its induction on endothelial cells by cytokines. Transplantation, 70 (4), pp. 579-586.

Maibaum, M., Haywood, M., Walport, M. and Morley, B. J., 2000. Lupus susceptibility loci map within regions of BXSB derived from the SB/Le parental strain. Immunogenetics, 51 (4-5), pp. 370-372.

Stocker, C., Sugars, K., Harari, O., Landis, R., Morley, B. J. and Haskard, D., 2000. TNF-α, IL-4, and IFN-γ regulate differential expression of P- and E-selectin expression by porcine aortic endothelial cells. The Journal of Immunology, 164, pp. 3309-3315.

Pritchard, N., Cutler, A., Uribe, S., Chadban, S., Morley, B. J. and Smith, K., 2000. Autoimmune-prone mice share a promoter haplotype associated with reduced expression and function of the Fc receptor FcγRII. Current Biology, 10 (4), pp. 227-230.

Haywood, M., Hogarth, M., Slingsby, J., Rose, S., Allen, P., Thompson, E., Maibaum, M., Chandler, P., Davies, K., Simpson, E., Walport, M. and Morley, B. J., 2000. Identification of intervals on chromosomes 1, 3, and 13 linked to the development of lupus in BXSB mice. Arthritis & Rheumatism, 43 (2), pp. 349-355.

Maibaum, M., Fu, G., Haywood, M., Uribe, S., Rose, S., Sim, R., Walport, M. and Morley, B. J., 1999. Candidate gene analysis in the lupus-prone mouse strain, BXSB. The American Journal of Human Genetics, 65, A262-A262.

Haywood, M., Hogarth, M., Slingsby, J., Rose, S., Thompson, E., Maibaum, M., Walport, M. and Morley, B. J., 1999. Genome-wide linkage analyses in the lupus-prone mouse strain, BXSB. The American Journal of Human Genetics, 65, A105-A105.

Hogarth, M., Slingsby, J., Allen, P., Thompson, E., Chandler, P., Davies, K., Simpson, E., Morley, B. J. and Walport, M., 1998. Multiple lupus susceptibility loci map to chromosome 1 in BXSB mice. The Journal of Immunology, 161, pp. 2753-2761.

Vaishnaw, A., Mitchell, T., Rose, S., Walport, M. and Morley, B. J., 1998. Regulation of transcription of the TATA-less human complement component C4 gene. The Journal of Immunology, 160, pp. 4353-4360.

Morley, B. J., Bartok, I., Spath, P., Vyse, T., Schneider, P. and Walport, M., 1998. Molecular basis of hereditary factor I deficiency. Molecular Immunology, 35 (6-7), p. 344.

Mitchell, T., Vaishnaw, A., Rose, J., Walport, M. and Morley, B. J., 1998. Transcriptional regulation of the human C4 gene. Molecular Immunology, 35 (6-7), p. 344.

Slingsby, J., Hogarth, M., Walport, M. and Morley, B. J., 1997. Polymorphism in the Ly-17 alloantigenic system of the mouse FcgRII gene. Immunogenetics, 46 (4), pp. 361-362.

Walport, M., Davies, K., Morley, B. J. and Botto, M., 1997. Complement deficiency and autoimmunity. Annals of the New York Academy of Sciences, 815 (Issue B-Lymphocytes ), pp. 267-281.

Mitchell, T., Vaishnaw, A., Rose, S., Walport, M. and Morley, B. J., 1996. Tissue specific transcriptional control of the human complement C4 gene is directed by the first 126bp of the promoter. Immunology, 89, A3-A3.

Topaloglu, R., Bakkaloglu, A., Slingsby, J., Mihatsch, M., Pascual, M., Norsworthy, P., Morley, B. J., Saatci, U., Schifferli, J. and Walport, M., 1996. Molecular basis of hereditary C1q deficiency associated with SLE and IgA nephropathy in a Turkish family. Kidney International, 50 (2), pp. 635-642.

Mitchell, T., Naughton, M., Norsworthy, P., Davies, K., Walport, M. and Morley, B. J., 1996. IFN-gamma up-regulates expression of the complement components C3 and C4 by stabilization of mRNA. The Journal of Immunology, 156 (11), pp. 4429-4434.

Hogarth, M., Norsworthy, P., Allen, P., Trinder, P., Loos, M., Morley, B. J., Walport, M. and Davies, K., 1996. Autoantibodies to the collagenous region of C1q occur in three strains of lupus-prone mice. Clinical And Experimental Immunology, 104 (2), pp. 241-246.

Slingsby, J., Norsworthy, P., Pearce, G., Vaishnaw, A., Issler, H., Morley, B. J. and Walport, M., 1996. Homozygous hereditary C1q deficiency and systemic lupus erythematosus: A new family and the molecular basis of C1q deficiency in three families. Arthritis & Rheumatism, 39 (4), pp. 663-670.

Slingsby, J., Dyson, P., Morley, B. J., Walport, M. and Simpson, E., 1996. Localization of mtv44 to the centromeric region of mouse chromosome 11. Mammalian Genome, 7 (4), pp. 319-320.

Petry, F., McClive, P., Botto, M., Morley, B. J., Morahan, G. and Loos, M., 1996. The mouse C1q genes are clustered on chromosome 4 and show conservation of gene organization. Immunogenetics, 43 (6), pp. 370-376.

Vyse, T., Morley, B. J., Bartok, I., Theodoridis, E., Davies, K., Webster, A. and Walport, M., 1996. The molecular basis of hereditary complement factor I deficiency. Journal of Clinical Investigation, 97 (4), pp. 925-933.

Slingsby, J., Hogarth, M., Simpson, E., Walport, M. and Morley, B. J., 1996. New microsatellite polymorphisms identified between C57BL/6, C57BL/10, and C57BL/KsJ inbred mouse strains. Immunogenetics, 43 (1-2), pp. 72-75.

Slingsby, J., Pearce, G., Norsworthy, P., Davies, K., Issler, H., Morley, B. J. and Walport, M., 1995. Molecular-basis of complete functional C1Q deficiency in 3 patients. Arthritis & Rheumatism, 38 (Suppl. S), p. 184.

Vaishnaw, A., Hargreaves, R., Campbell, R., Morley, B. J. and Walport, M., 1995. DNase I hypersensitivity mapping and promoter polymorphism analysis of human C4. Immunogenetics, 41 (6), pp. 354-358.

Vyse, T., Bates, G., Walport, M. and Morley, B. J., 1994. The organization of the human complement factor I gene (IF): a member of the serine protease gene family. Genomics, 24 (1), pp. 90-98.

Vyse, T., Spath, P., Davies, K., Morley, B. J., Philippe, P., Athanassiou, P., Giles, C. and Walport, M., 1994. Hereditary complement factor I deficiency. QJM: An International Journal of Medicine, 87, pp. 385-401.

Botto, M., Fong, K., So, A., Barlow, R., Routier, R., Morley, B. J. and Walport, M., 1992. Homozygous hereditary C3 deficiency due to a partial gene deletion. Proceedings of the National Academy of Sciences of the United States of America (PNAS), 89 (11), pp. 4957-4961.

Hohler, T., Botto, M., Routier, R., Morley, B. J. and Walport, M., 1992. A simple method for identifying complement component C3 polymorphisms. British Journal of Rheumatology, 31 (10), p. 10.

Conference or Workshop Items

Maniati, E., Aw, D., Palmer, D., Morley, B. J. and Rogers, N., 2008. Alterations of the thymic environment in murine models of SLE. In: Annual Congress of the British Society of Immunology, 2008-11-17 - 2008-11-21, Glasgow, Scotland.

Gabriel, L., Mniati, E., Rose, S., Morley, B. J. and Rogers, N., 2008. Characterisation of T helper profile in a murine model of SLE. In: Annual Congress of the British Society of Immunology, 2008-11-17 - 2008-11-21, Glasgow, Scotland.

Gabriel, L., Maniati, E., Morley, B. J. and Rogers, N., 2008. The role of NKT cells in the immunopathology of systemic lupus erythematosus. In: Annual Congress of the British Society of Immunology, 2008-11-17 - 2008-11-21, Glasgow, Scotland.

Maniati, E., Gomes, M., Gabriel, L., Morley, B. J. and Rogers, N., 2008. The role of toll-like receptors in the BXSB model of SLE. In: Annual Congress of the British Society of Immunology, 2008-11-17 - 2008-11-21, Glasgow, Scotland.

Gabriel, L., Morley, B. J. and Rogers, N., 2008. The role of iNKT cells in the immunopathology of systemic lupus erythematosus. In: Shoenfeld, Y. and Gershwin, M., eds. 6th International Congress on Autoimmunity, 2008-09-10 - 2008-09-14, Porto.

Gabriel, L., Haywood, M., Rose, S., Rogers, N., Izui, S. and Morley, B. J., 2007. BXSB/long-lived is a recombinant inbred strain containing powerful disease suppressor loci. In: Annual Congress of the British Society of Immunology, 2007-02-20 - 2007-02-23, Glasgow, Scotland.

Maniati, E., Rogers, N. and Morley, B. J., 2007. Lymphoid tissue distribution of DC subtypes in a murine model of SLE. In: Annual Congress of the British Society of Immunology, 2007-02-20 - 2007-02-23, Glasgow, Scotland.

Haywood, M., Rose, S., Rankin, J., Izui, S., Rogers, N. and Morley, B. J., 2005. The Y-linked autoimmune accelerator (YAA) gene is sufficient to break immunological tolerance. In: Joint Meeting of the British Society for Rheumatology/Deutsche Gesellschaft fur Rheumatologie and Spring Meeting of the British Health Professionals in Rheumatology, 2005-04-19 - 2005-04-22, Birmingham.

Rogers, N., Gabriel, L., Nunes, C., Rose, J. and Morley, B. J., 2005. The role of CD4 T cells in the loss of tolerance in a murine model of SLE. In: Joint Meeting of the British Society for Rheumatology/Deutsche Gesellschaft fur Rheumatologie and Spring Meeting of the British Health Professionals in Rheumatology, 2005-04-19 - 2005-04-22, Birmingham.

Rigby, R., Horswell, S., Haywood, M., Shoulders, C., Morley, B. J. and Vyse, T., 2005. Differential transcript profiling identifies candidate genes in the New Zealand model of systemic lupus erythematosus, including the B-cell transcription factor, Bach2. In: 5th Annual Meeting of the Federation of Clinical Immunology Society, 2005-05-12 - 2005-05-14, Boston.

This list was generated on Mon Sep 1 11:25:52 2014 IST.