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Items by Husbands, Stephen

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Number of items: 87.

Kumar, V., Clark, M.J., Traynor, J.R., Lewis, J.W. and Husbands, S.M., 2014. Pyrrolo- and pyridomorphinans : Non-selective opioid antagonists and delta opioid agonists/mu opioid partial agonists. Bioorganic and Medicinal Chemistry, 22 (15), pp. 4067-4072.

Cordery, S. F., Taverner, A., Ridzwan, I. E., Guy, R. H., Delgado-Charro, M. B., Husbands, S. M. and Bailey, C. P., 2014. A non-rewarding, non-aversive buprenorphine/naltrexone combination attenuates drug-primed reinstatement to cocaine and morphine in rats in a conditioned place preference paradigm. Addiction Biology, 19 (4), pp. 575-586.

Khroyan, T. V., Wu, J., Polgar, W. E., Cami-Kobeci, G., Fotaki, N., Husbands, S. M. and Toll, L., 2014. Forthcoming. BU08073 a buprenorphine analog with partial agonist activity at mu receptors in vitro but long-lasting opioid antagonist activity in vivo in mice. British Journal of Pharmacology

Parker, C.A., Nabulsi, N., Holden, D., Lin, S.-F., Cass, T., Labaree, D., Kealey, S., Gee, A.D., Husbands, S.M., Quelch, D., Carson, R.E., Nutt, D.J., Huang, Y. and Tyacke, R.J., 2014. Evaluation of 11C-BU99008, a PET Ligand for the Imidazoline Binding Sites in Rhesus Brain. The Journal of Nuclear Medicine, 55 (5), pp. 838-844.

Kealey, S., Husbands, S. M., Bennacef, I., Gee, A. D. and Passchier, J., 2014. Palladium-mediated oxidative carbonylation reactions for the synthesis of 11C-radiolabelled ureas. Journal of Labelled Compounds & Radiopharmaceuticals, 57 (4), pp. 202-208.

Ju, M., Scott-ward, T. S., Liu, J., Khuituan, P., Li, H., Cai, Z., Husbands, S. M. and Sheppard, D. N., 2014. Loop diuretics are open-channel blockers of the cystic fibrosis transmembrane conductance regulator with distinct kinetics. British Journal of Pharmacology, 171 (1), pp. 265-278.

Casal-Dominguez, J. J., Furkert, D., Ostovar, M., Teintang, L., Clarke, M. J., Traynor, J. R., Husbands, S. M. and Bailey, S. J., 2014. Characterization of BU09059 : A novel potent selective κ-receptor antagonist. ACS Chemical Neuroscience, 5 (3), pp. 177-184.

Almatroudi, A., Husbands, S. M., Bailey, C. P. and Bailey, S. J., 2014. Combination Treatment With Buprenorphine/Naltrexone, A Functional Kappa Opioid Receptor Antagonist, Produces Antidepressant-Like Effects In Mice. Journal of Psychopharmacology, 28 (8), A101.

Kumar, V., Ridzwan, I.E., Grivas, K., Lewis, J.W., Clark, M.J., Meurice, C., Jimenez-Gomez, C., Pogozheva, I., Mosberg, H., Traynor, J.R. and Husbands, S.M., 2014. Selectively promiscuous opioid ligands : Discovery of high affinity/low efficacy opioid ligands with substantial nociceptin opioid peptide receptor affinity. Journal of Medicinal Chemistry, 57 (10), pp. 4049-4057.

Sukhtankar, D. D., Zaveri, N. T., Husbands, S. M. and Ko, M.-C., 2013. Effects of spinally administered bifunctional nociceptin/orphanin FQ peptide receptor/μ-opioid receptor ligands in mouse models of neuropathic and inflammatory pain. Journal of Pharmacology and Experimental Therapeutics, 346 (1), pp. 11-22.

Ko, M.-C. and Husbands, S. M., eds., 2013. Research and Development of Opioid-Related Ligands. Washington, DC: American Chemical Society. (ACS Symposium Series; 1131)

Casal-Dominguez, J. J., Clark, M., Traynor, J. R., Husbands, S. M. and Bailey, S. J., 2013. In vivo and in vitro characterization of naltrindole-derived ligands at the κ-opioid receptor. Journal of Psychopharmacology, 27 (2), pp. 192-202.

Kealey, S., Turner, E.M., Husbands, S.M., Salinas, C.A., Jakobsen, S., Tyacke, R.J., Nutt, D.J., Parker, C.A. and Gee, A.D., 2013. Imaging imidazoline-I binding sites in porcine brain using C-BU99008. The Journal of Nuclear Medicine, 54 (1), pp. 139-144.

Cordery, S. F., Taverner, A., Ridzwan, I. E., Guy, R. H., Delgado-Charro, M. B., Husbands, S. M. and Bailey, C. P., 2013. A non-rewarding, non-aversive buprenorphine/naltrexone combination attenuates drug-primed reinstatement to cocaine and morphine in rats in a conditioned place preference paradigm. Addiction Biology

Husbands, S. M., 2013. Buprenorphine and related orvinols. In: Ko, M.-C. and Husbands, S. M., eds. Research and Development of Opioid-Related Ligands. Washington, DC: American Chemical Society, pp. 127-144. (ACS Symposium Series; 1131)

Almatroudi, A., Husbands, S. M., Bailey, C. P. and Bailey, S. J., 2013. Establishing the combination of buprenorphine and naltrexone as a functional kappa opioid receptor antagonist in mice. Proceedings of the British Pharmacological Society

Greedy, B. M., Bradbury, F., Thomas, M. P., Grivas, K., Cami-Kobeci, G., Archambeau, A., Bosse, K., Clark, M. J., Aceto, M., Lewis, J. W., Traynor, J. R. and Husbands, S. M., 2013. Orvinols with mixed kappa/mu opioid receptor agonist activity. Journal of Medicinal Chemistry, 56 (8), pp. 3207-3216.

Toll, L., Khroyan, T. V., Polgar, W. E., Husbands, S. M. and Zaveri, N. T., 2013. Pharmacology of mixed NOP/mu ligands. In: Ko, M.-C. and Husbands, S. M., eds. Research and Development of Opioid-Related Ligands. Washington, DC: American Chemical Society, pp. 369-391. (ACS Symposium Series; 1131)

Tyacke, R. J., Fisher, A., Robinson, E. S., Grundt, P., Turner, E. M., Husbands, S. M., Hudson, A. L., Parker, C. A. and Nutt, D. J., 2012. Evaluation and initial in vitro and ex vivo characterization of the potential positron emission tomography ligand, BU99008 (2-(4,5-Dihydro-1H-imidazol-2-yl)-1- methyl-1H-indole), for the imidazoline 2 binding site. Synapse, 66 (6), pp. 542-551.

Turner, E. M., Blazer, L. L., Neubig, R. R. and Husbands, S. M., 2012. Small molecule inhibitors of regulators of G protein signaling (RGS) proteins. ACS Medicinal Chemistry Letters, 3 (2), pp. 146-150.

Bailey, S., Casal-Dominguez, J. and Husbands, S. M., 2012. Antidepressant effects of novel kappa-opioid receptor antagonists in the forced swim test. Journal of Psychopharmacology, 26 (8), A16.

Cami-Kobeci, G., Polgar, W. E., Khroyan, T. V., Toll, L. and Husbands, S. M., 2011. Structural determinants of opioid and NOP receptor activity in derivatives of buprenorphine. Journal of Medicinal Chemistry, 54 (19), pp. 6531-6537.

Kealey, S., Gee, A. D., Husbands, S. M., Bennacef, I. and Passchier, J., 2011. (11)C Urea synthesis via palladium(II)-mediated oxidative carbonylation of amines. Journal of Labelled Compounds & Radiopharmaceuticals, 54 (Supplement 1), S108.

Long, N., Kealey, S., Jennings, L., Miller, P., Gee, A., Plisson, C., White, A. and Husbands, S. M., 2011. Copper(I) tris(pyrazolyl)borate complexes for use in positron emission tomography. Journal of Labelled Compounds & Radiopharmaceuticals, 54 (Supplement 1), S98.

Kealey, S., Plisson, C., Collier, T. L., Long, N. J., Husbands, S. M. and Gee, A. D., 2011. Solution (11)C carbonylation chemistry for the synthesis of a PET tracer - (11)C MK0233. Journal of Labelled Compounds & Radiopharmaceuticals, 54 (Supplement 1), S107.

Kealey, S., Husbands, S. M., Casey, E., Salinas, C. A., Parker, C. A., Jakobsen, S., Tyacke, R. J., Nutt, D. J. and Gee, A. D., 2011. Synthesis and in vivo evaluation of (11)C BU99008 as a ligand for the imidazoline I(2) binding site. Journal of Labelled Compounds & Radiopharmaceuticals, 54 (Supplement 1), S304.

Kealey, S., Jennings, L. E., Miller, P. W., Gee, A. D., Plisson, C., White, A. J. P., Husbands, S. and Long, N. J., 2011. Copper(I) tris(pyrazolyl)borate complexes for use in positron emission tomograhpy. Journal of Labelled Compounds & Radiopharmaceuticals, 54 (7), p. 392.

Blazer, L. L., Zhang, H. M., Casey, E. M., Husbands, S. M. and Neubig, R. R., 2011. A nanomolar-potency small molecule inhibitor of regulator of G-protein signaling proteins. Biochemistry, 50 (15), pp. 3181-3192.

Khroyan, T. V., Polgar, W. E., Cami-Kobeci, G., Husbands, S. M., Zaveri, N. T. and Toll, L., 2011. The first universal opioid ligand, (2S)-2- (5R,6R,7R,14S)-N-cyclopropylmethyl-4,5-epoxy-6,14-ethano-3-hydro xy-6-methoxymorphinan-7-yl -3,3-dimethylpentan-2-ol (BU08028): Characterization of the in vitro profile and in vivo behavioral effects in mouse models of acute pain and cocaine-induced reward. Journal of Pharmacology and Experimental Therapeutics, 336 (3), pp. 952-961.

Bailey, S. J., Casal-Dominguez, J. J. and Husbands, S. M., 2011. Anxiolytic effects of novel kappa-opioid receptor antagonists in the elevated plus maze. Journal of Psychopharmacology, 25 (8), A76.

Kealey, S., Plisson, C., Collier, T. L., Long, N. J., Husbands, S. M., Martarello, L. and Gee, A. D., 2011. Microfluidic reactions using C-11 carbon monoxide solutions for the synthesis of a positron emission tomography radiotracer. Organic and Biomolecular Chemistry, 9 (9), pp. 3313-3319.

Taverner, A., Cordery, S., Husbands, S. M., Guy, R. H., Delgado-Charro, B. M. and Bailey, C. P., 2011. Transdermal delivery of a buprenorphine/naltrexone combination for the treatment of polydrug abuse. Pharmacological Reports, 63 (1), p. 257.

Cami-Kobeci, G., Polgar, W. E., Khroyan, T. V., Toll, L. and Husbands, S. M., 2011. Universal opioid receptor ligands - buprenorphine and related orvinols. Pharmacological Reports, 63 (1), p. 210.

Pichika, R., Jewett, D. M., Sherman, P. S., Traynor, J. R., Husbands, S. M., Woods, J. H. and Kilbourn, M. R., 2010. Synthesis and in vivo brain distribution of carbon-11-labeled delta-opioid receptor agonists. Nuclear Medicine and Biology, 37 (8), pp. 989-996.

Blazer, L. L., Roman, D. L., Chung, A., Larsen, M. J., Greedy, B. M., Husbands, S. M. and Neubig, R. R., 2010. Reversible, allosteric small-molecule inhibitors of regulator of G protein signaling proteins. Molecular Pharmacology, 78 (3), pp. 524-533.

Bailey, S. J., Casal-Dominguez, J. J., Bradbury, F. A., Traynor, J. R. and Husbands, S. M., 2010. In vivo characterisation of 5'-amino and amidino-alkyl,naltrindole derivatives at the kappa-opioid receptor. Journal of Psychopharmacology, 24 (Supplement 3), A42.

Kealey, S., Husbands, S., Casey, E. M., Salinas, C. A., Parker, C. A., Jakobsen, S., Tyacke, R. J., Nutt, D. J. and Gee, A. D., 2010. Synthesis and in vivo evaluation of 11C BU99008 as a ligand for the imidazoline 12 binding site. NeuroImage, 52 (Supplement 1), S127-S128.

Kimura, A., Tyacke, R. J., Robinson, J. J., Husbands, S. M., Minchin, M. C. W., Nutt, D. J. and Hudson, A. L., 2009. Identification of an imidazoline binding protein: Creatine kinase and an imidazoline-2 binding site. Brain Research, 1279, pp. 21-28.

Moynihan, H., Jales, A. R., Greedy, B. M., Rennison, D., Broadbear, J. H., Purington, L., Traynor, J. R., Woods, J. H., Lewis, J. W. and Husbands, S. M., 2009. 14β-O-cinnamoylnaltrexone and related dihydrocodeinones are mu opioid receptor partial agonists with predominant antagonist activity. Journal of Medicinal Chemistry, 52 (6), pp. 1553-1557.

Nieland, N. P. R., Rennison, D., Broadbear, J. H., Purington, L., Woods, J. H., Traynor, J. R., Lewis, J. W. and Husbands, S. M., 2009. 14β-Arylpropiolylamino-17-cyclopropylmethyl-7,8-dihydronormorphinones and Related Opioids. Further Examples of Pseudoirreversible μ Opioid Receptor Antagonists. Journal of Medicinal Chemistry, 52 (21), pp. 6926-6930.

Ko, M. C. and Husbands, S. M., 2009. Effects of atypical kappa-opioid receptor agonists on intrathecal morphine-induced itch and analgesia in primates. Journal of Pharmacology and Experimental Therapeutics, 328 (1), pp. 193-200.

Cami-Kobeci, G., Neale, A. P., Bradbury, F. A., Purington, L. C., Aceto, M. D., Harris, L. S., Lewis, J. W., Traynor, J. R. and Husbands, S. M., 2009. Mixed κ/μ Opioid Receptor Agonists: The 6β-Naltrexamines. Journal of Medicinal Chemistry, 52 (6), pp. 1546-1552.

Collins, G. T., Truccone, A., Haji-Abdi, F., Newman, A. H., Grundt, P., Rice, K. C., Husbands, S. M., Greedy, B. M., Enguehard-Gueiffier, C., Gueiffier, A., Chen, J., Wang, S., Katz, J. L., Grandy, D. K., Sunahara, R. K. and Woods, J. H., 2009. Proerectile Effects of Dopamine D2-Like Agonists Are Mediated by the D3 Receptor in Rats and Mice. Journal of Pharmacology and Experimental Therapeutics, 329 (1), pp. 210-217.

Koffarnus, M. N., Greedy, B., Husbands, S. M., Grundt, P., Newman, A. H. and Woods, J. H., 2009. The discriminative stimulus effects of dopamine D2-and D3-preferring agonists in rats. Psychopharmacology, 203 (2), pp. 317-327.

Spagnolo, B., Calo, G., Polgar, W. E., Jiang, F., Olsen, C. M., Berzetei-Gurske, I., Khroyan, T. V., Husbands, S. M., Lewis, J. W., Toll, L. and Zaveri, N. T., 2008. Activities of mixed NOP and μ-opioid receptor ligand. British Journal of Pharmacology, 153 (3), pp. 609-619.

Rennison, D., Neal, A. P., Cami-Kobeci, G., Aceto, M. D., Martinez-Bermejo, F., Lewis, J. W. and Husbands, S. M., 2007. Cinnamoyl Derivatives of 7α-Aminomethyl-6,14-endoethanotetrahydrothebaine and 7α-Aminomethyl-6,14-endoethanotetrahydrooripavine and Related Opioid Ligands. Journal of Medicinal Chemistry, 50 (21), pp. 5176-5182.

Furkert, D. P. and Husbands, S. M., 2007. First asymmetric synthesis of trans -3,4-dimethyl-4-arylpiperidines. Organic Letters, 9 (19), pp. 3769-3771.

Li, Y., Husbands, S. M., Mahon, M. F., Traynor, J. R. and Rowan, M. G., 2007. Isolation and chemical modification of clerodane diterpenoids from Salvia species as potential agonists at the k -opioid receptor. Chemistry & Biodiversity, 4 (7), pp. 1586-1593.

Ghazaleh, H. A., Lalies, M. D., Husbands, S. M., Nutt, D. J. and Hudson, A. L., 2007. The effect of 1-(4,5-dihydro-1 H -imidazol-2-yl) on monoamine release ajnd turnover in the rat frontal cortex. Neuroscience Letters, 422, pp. 109-113.

Collins, G. T., Newman, A. H., Grundt, P., Rice, K. C., Husbands, S. M., Chauvignac, C., Chen, J., Wang, S. and Woods, J. H., 2007. Yawning and hypothermia in rats: effects of dopamine D3 and D2 agonists and antagonists. Psychopharmacology

Rennison, D., Moynihan, H., Traynor, J. R., Lewis, J. W. and Husbands, S. M., 2006. Structural determinants of opioid activity in derivatives of 14-aminomorphinones: effects of changes to the chain linking of the C14 -amino group to the aryl ring. Journal of Medicinal Chemistry, 49 (20), pp. 6104-6110.

Anderson, N. J., Tyacke, R. J., Husbands, S. M., Nutt, D. J., Hudson, A. L. and Robinson, E. S. J., 2006. In vitro and ex vivo distribution of [ 3 H]harmane, an endogenous β-carboline, in rat brain. Neuropharmacology, 50, pp. 269-276.

Nieland, N. P. R., Moynihan, H. A., Carrington, S., Broadbear, J., Woods, J. H., Traynor, J. R., Husbands, S. M. and Lewis, J. W., 2006. Structural determinants of opioid activity in derivatives of 14-aminomorphinones: effect of substitution in the aromatic ring of cinnamoylaminomorphines and codeinones. Journal of Medicinal Chemistry, 49, pp. 5333-5338.

Janciene, R., Stumbreviciute, Z., Podeniene, D., Puodziunaite, B. D., Black, S. and Husbands, S. M., 2006. Synthesis of novel 1-substituted [1,3]thiazolo[3,2- a ]-[1,5]benzodiazepine derivatives from 1,5-benzodiazepine-2-thiones and α-halogen carbonyl compounds. Journal of Heterocyclic Chemistry, 43, pp. 979-984.

Husbands, S. M., Neilan, C. L., Broadbear, J., Grundt, P., Breeden, S., Aceto, M. D., Woods, J. H., Lewis, J. W. and Traynor, J. R., 2005. BU74, a complex oripavine derivative with potent kappa opioid receptor agonism and delayed opioid antagonism. European Journal of Pharmacology, 509, pp. 117-125.

Terner, J. M., Lomas, L. M., Lewis, J. W., Husbands, S. M. and Picker, M. J., 2005. Effects of the long-lasting kappa opioid 2-(3,4-dichloro-phenyl)- N -methyl- N -[(1 S )-1-(3-isothiocyanatophenyl)-2-(1-pyrrolidinyl) ethyl] acetamide in a drug discrimination and warm water tail-withdrawal procedure. Behavioural Pharmacology, 16 (8), pp. 665-670.

Shefali, [N. V.], Srivastava, S. K., Husbands, S. M. and Lewis, J. W., 2005. Extension of the nenitzescu reaction to simple ketones provides an efficient route to 1'-alkyl-5'-hydroxynaltrindole analogues, potent and selective δ-opioid receptor antagonists. Journal of Medicinal Chemistry, 48, pp. 635-638.

Rennison, D., Grundt, P., Goodyer, C., Lewis, J. W. and Husbands, S. M., 2005. Formic acid catalysed rearrangement of 5β-methyldihydrothevinols (=3,6-dimethoxy-5,17-dimethyl1-4,5-epoxy-6,14-ethanomorphinan-7-methanols): synthesis of new doubly bridged morphinan derivatives. Chemistry & Biodiversity, 2, pp. 215-220.

Chauvignac, C., Miller, C. N., Srivastava, S. K., Lewis, J. W., Husbands, S. M. and Traynor, J. R., 2005. Major effect of pyrrolic N-benzylation in norbinaltorphimine, the selective k -opioid receptor antagonist. Journal of Medicinal Chemistry, 48, pp. 1676-1679.

Neilan, C. L., Husbands, S. M., Breeden, S., Ko, M. C., Aceto, M. D., Lewis, J. W., Woods, J. H. and Traynor, J. R., 2004. Characterization of the complex morphinan derivative BU72 as a high efficacy, long-lasting mu-opioid receptor agonist. European Journal of Pharmacology, 499, pp. 107-116.

Srivastava, S. K., Shefali, [N. V.], Miller, C. N., Aceto, M. D., Traynor, J. R., Lewis, J. W. and Husbands, S. M., 2004. Effects of substitution on the pyrrole N atom in derivatives of tetrahydronaltrindole, tetrahydrooxymorphindole, and a related 4,5-epoxyphenylpyrrolomorphinan. Journal of Medicinal Chemistry, 47, pp. 6645-6648.

Parker, C. A., Anderson, N. J., Robinson, E. S. J., Price, R., Tyacke, R. J., Husbands, S. M., Dillon, M. P., Eglen, R. M., Hudson, A. L., Nutt, D. J., Crump, M. P. and Crosby, J., 2004. Harmane and harmalan are bioactive components of classical clonidine-displacing substance. Biochemistry, 43, pp. 16385-16392.

Grundt, P., Williams, I. A., Lewis, J. W. and Husbands, S. M., 2004. Identification of a new scaffold for opioid receptor antagonism based on the 2-amino-1,1-dimethyl-7-hydroxytetralin pharmacophore. Journal of Medicinal Chemistry, 47 (21), pp. 5069-5075.

Husbands, S. M., 2004. Kappa-opioid receptor ligands. Expert Opinion on Therapeutic Patents, 14 (12), pp. 1725-1741.

Robinson, E. S. J., Tyacke, R. J., Finch, L., Willmott, G., Husbands, S., Nutt, D. J. and Hudson, A. L., 2004. Pharmacological characterisation of novel α 2 -adrenoceptor antagonists as potential brain imaging events. Neuropharmacology, 46, pp. 847-855.

Lewis, J. W. and Husbands, S. M., 2004. The orvinols and related opioids - high affinity ligands with diverse efficacy profiles. Current Pharmaceutical Design, 10, pp. 717-732.

Grundt, P., Jales, A. R., Traynor, J. R., Lewis, J. W. and Husbands, S. M., 2003. 14-amino, 14-alkylamino, and 14-acylamino analogs of oxymorphindole. Differential effects on opioid receptor binding and functional profiles. Journal of Medicinal Chemistry, 46, pp. 1563-1566.

Katz, J. L., Libby, T. A., Kopajtic, T., Husbands, S. M. and Newman, A. H., 2003. Behavioral effects of rimcazole analogues alone and in combination with cocaine. European Journal of Pharmacology, 468, pp. 109-119.

Anderson, N. J., Robinson, E. S. J., Husbands, S. M., Delagrange, P., Nutt, D. J. and Hudson, A. L., 2003. Characterization of [3H]Harmane Binding to Rat Whole Brain Membranes. Annals of the New York Academy of Sciences, 1009 (1), pp. 175-179.

Cao, J., Kulkarni, S. S., Husbands, S. M., Bowen, W. D., Williams, W., Kopajtic, T., Katz, J. L., George, C. and Newman, A. H., 2003. Dual probles for the dopamine transporter and σ1 receptors: novel piperazinyl alkyl-bis(4'-fluorophenyl)amyl analogues as potential cocaine-abuse therapeutic agents. Journal of Medicinal Chemistry, 46, pp. 2589-2598.

Grundt, P., Martinez Bermejo, F., Lewis, J. W. and Husbands, S. M., 2003. Formic acid catalyzed rearrangement of thevinols(=4,5-Epoxy-3,6-dimethoxy- α ,17-dimethyl-6,14-ethenomorphinan-7-methanols) and their vinylogous analogues: effects of 5 β -methyl substitution. Helvetica Chimica Acta, 86, pp. 2287-2298.

Black, S. L., Chauvignac, C., Grundt, P., Miller, C. N., Wood, S., Traynor, J. R., Lewis, J. W. and Husbands, S. M., 2003. Guanidino N-substituted and N,N-disubstituted derivatives of the k -opioid antagonist GNTI. Journal of Medicinal Chemistry, 46, pp. 5505-5511.

Hudson, A. L., Tyacke, R. J., Lalies, M. D., Davies, N., Finn, D. P., Martí, O., Robinson, E., Husbands, S. M., Minchin, M. C. W., Kimura, A. and Nutt, D. J., 2003. Novel ligands for the investigation of imidazoline receptors and their binding proteins. Annals of the New York Academy of Sciences, 1009, pp. 302-308.

Grundt, P., Martinez-Bermejo, F., Lewis, J. W. and Husbands, S. M., 2003. Opioid binding and in vitro profiles of a series of 4-hydroxy-3-methoxyindolomorphinans. Transformation of a δ-selective ligand into a high affinity k -selective ligand by introduction of a 5,14-substituted bridge. Journal of Medicinal Chemistry, 46, pp. 3174-3177.

Husbands, S. M. and Lewis, J. W., 2003. Opioid ligands having delayed long-term antagonist activity: potential pharmacotherapies for opioid abuse. Mini-Reviews in Medicinal Chemistry, 3, pp. 137-144.

Grundt, P., Martinez-Bermejo, F., Lewis, J. W. and Husbands, S. M., 2003. The 14-alkyl- and 14-alkenyl-5β-methylindolomorphinan series provide δ-selective partial opioid agonists. Helvetica Chimica Acta, 86, pp. 793-798.

Black, S. L., Jales, A. R., Brandt, W., Lewis, J. W. and Husbands, S. M., 2003. The role of the side chain in determining relative δ- and k -affinity in C5'-substituted analogues of naltrindole. Journal of Medicinal Chemistry, 46, pp. 314-317.

Srivastava, S. K., Husbands, S. M., Traynor, J. R. and Lewis, J. W., 2002. 4'-arylpyrrolomorphinans: effect of a pyrrolo-N-benzyl substituent in enhancing δ-opioid antagonist activity. Journal of Medicinal Chemistry, 45, pp. 537-540.

Shefali, [N. V.], Srivastava, S. K., Hall, L. D., Lewis, J. W. and Husbands, S. M., 2002. Michael reactions of benzylimines derived from morphinan-6-ones: synthesis of pyrrolo- and pyridinomorphinans. Helvetica Chimica Acta, 85, pp. 1790-1799.

Tyacke, R. J., Robinson, E. S. J., Schabel, R., Lewis, J. W., Husbands, S. M., Nutt, D. J. and Hudson, A. L., 2002. N1' -fluoroethyl-naltrindole (BU97001) and N1' -fluoroethyl-(14-formylamino)-naltrindole (BU97018) potential δ-opioid receptor PET ligands. Nuclear Medicine & Biology, 29, pp. 455-462.

Robarge, M. J., Husbands, S. M., Kieltyka, A., Brodbeck, R., Thurkauf, A. and Newman, A. H., 2001. Design and synthesis of [(2,3-dichlorophenyl)piperazin-1-yl]alkyfluorenylcarboxamides as novel ligands selective for the dopamine D 3 receptor subtype. Journal of Medicinal Chemistry, 44, pp. 3175-3186.

Hudson, A. L., Nutt, D. J. and Husbands, S. M., 2001. Imidazoline receptors and their role in depression. Pharmaceutical News, 8 (3), pp. 18-24.

Matsumoto, R. R., Hewett, K. L., Pouw, B., Husbands, S. M., Cao, J. J. and Newman, A. H., 2001. Rimcazole analogs attenuate the convulsive effects of cocaine: correlation with binding to sigma receptors rather than dopamine transporters. Neuropharmacology, 42, pp. 878-886.

Clayson, J., Jales, A. R., Tyacke, R. J., Hudson, A. L., Nutt, D. J., Lewis, J. W. and Husbands, S. M., 2001. Selective δ-opioid receptor ligands: potential PET ligands based on naltrindole. Bioorganic & Medicinal Chemistry Letters, 11, pp. 939-943.

McIntyre, B. G., Martinez Bermejo, F., Srivastava, S. K., Husbands, S. M., Lewis, J. W., Crosby, J. and Simpson, T. J., 2001. Solid phase synthesis of 4-hydroxycinnamic acid and its derivatives for potential use in combinatorial chemistry: a novel route for the synthesis of 4-hydroxycinnamoyl coenzyme A and NMDA receptor antagonists. Combinatorial Chemistry and High Throughput Screening, 4, pp. 111-114.

Cao, J., Husbands, S. M., Kopajtic, T., Katz, J. L. and Newman, A. H., 2001. [(3- cis -3,5-dimethyl-1-piperazinyl)alkyl-bis-(4'-fluorophenyl)amine analogs as novel probes for the dopamine transporter. Bioorganic & Medicinal Chemistry Letters, 11, pp. 3169-3173.

Husbands, S. M., Glennon, R. A., Gorgerat, S., Gough, R., Tyacke, R., Crosby, J., Nutt, D. J., Lewis, J. W. and Hudson, A. L., 2001. β-carboline binding to imidazoline receptors. Drug and Alcohol Dependence, 64, pp. 203-208.

This list was generated on Thu Oct 30 13:33:55 2014 GMT.